Patents by Inventor Roberto Cozzolino

Roberto Cozzolino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyroglutamic acid derivatives as enhancers of learning processes and memory and pharmaceutical compositions comprising same
    Patent number: 5227496
    Abstract: Orally or parenterally administrable pharmaceutical compositions in unit dosage form comprise from about 100 to about 500 mg of one of the compounds of formula (I). ##STR1## wherein R is selected from: 2-(N,N-diisopropyl)aminoethyl,2-aminoethyl,2-N-(pyrrolidin-2-one-1-yl)acetyl aminoethyl,2-phenylethyl,benzyl,2-N-(pyroglutamylglycyl)aminoethyl,2-N-(pyroglutamyl)aminoethyl;Y is either a C--N single bond or the bivalent residue of an aminoacid selected from: ##STR2## are potent enhancers of the learning processes and memory.
    Type: Grant
    Filed: April 7, 1992
    Date of Patent: July 13, 1993
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Fabio Giannessi, Orlando Ghirardi, Roberto Cozzolino, Domenico Misiti, Maria O. Tinti
  • Derivatives of 1,2,3,4-tetrahydronaphtylamine endowed with nootropic activity and pharmaceutical compositions containing same
    Patent number: 5192759
    Abstract: 1,2,3,4-tetrahydronaphthlamines of formula (1) ##STR1## wherein R is H or OCH.sub.3 ; ##STR2## is either at 1 or 2 position R.sub.1 is H;R.sub.2 is selected from:L-prolyl, optionally N-substituted with acetyl or carbobenzoxy,L-pyroglutamyl,(pyrrolidin-2-one-1-yl)acetyl,3-carboxy-2-hydroxypropyl:or R.sub.1 and R.sub.2 taken together with the nitrogen atom form the ring ##STR3## wherein n=1,2,3 and R.sub.3 -H, OH are nootropic substances potent enhancers of learning processes and memory.Orally or parenterally administrable pharmaceutical compositions in unit dosage form comprise between about 100 and about 500 mg of a compound of formula (1).
    Type: Grant
    Filed: December 18, 1991
    Date of Patent: March 9, 1993
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Fabio Giannessi, Orlando Ghirardi, Domenico Misiti, Maria O. Tinti, Roberto Cozzolino
  • Pharmaceutical compositions comprising 3-amino-.epsilon.-caprolactames for enhancing the process of learning and memory
    Patent number: 5166150
    Abstract: Pharmaceutical compositions for enhancing the process of learning and memory are disclosed, that contain as active principle a 3-amino-.epsilon.-caprolactam of formula (1) ##STR1## Wherein R is selected from the group consisting of hydrogen, formyl and acetyl.Orally or parenterally administrable pharmaceutical compositions in unit dosage form comprise from about 100 to about 500 mg of a compound of formula (1).
    Type: Grant
    Filed: June 21, 1991
    Date of Patent: November 24, 1992
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Orlando Ghirardi, Roberto Cozzolino, Fabio Giannessi, Domenico Misiti, Maria O. Tinti, Carlo Scolastico
  • 1-alkyl-3-(acylamino)-.epsilon.-caprolactames as enhancers of learning and memory and pharmaceutical compositions containing same
    Patent number: 5155102
    Abstract: 1-alkyl-3-(acylamino)-.epsilon.-caprolactames of formula (1) ##STR1## wherein R is selected from the group consisting of:pyrrolidin-2-one-1-acetyl,p-methoxybenzoyl,N-benzyloxycarbonyl-(S)-prolyl,phenylbutanoyl,3-trifluoromethylbenzoyl,3,4,5-trimethoxybenzoyl,nicotinoyl, andacyl having from 1 to 5 carbon atoms, andR.sub.1 is selected from the group consisting of:hydrogen,methoxycarbonylmethyl,aminocarbonylmethyl,2-hydroxyethyl, andformylmethyl,(provided that, if R.sub.1 is hydrogen, R is not formyl or acetyl) are potent enhancers of learning and memory.Orally or parenterally administrable pharmaceutical compositions in unit dosage form comprise from about 100 to 500 mg of one of the compound of formula (1).
    Type: Grant
    Filed: June 21, 1991
    Date of Patent: October 13, 1992
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Fabio Giannessi, Orlando Ghirardi, Domenico Misiti, Maria O. Tinti, Roberto Cozzolino, Carlo Scolastico