Patents by Inventor Roberto Di Domenico

Roberto Di Domenico has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20080268104
    Abstract: Cheese is particularly well adapted for certain applications, such as for example as a pizza topping, where there is a need for the cheese to melt and flow when heated. Conversely this property makes cheese particularly unsuited to pan-fried or oven cooked products where shape-retention is important. The aforementioned problem is solved by providing a food composition consisting of: a) 80-90% by weight of a cheese mixture; and b) 10-20% by weight starch, modified starch, cellulose, modified cellulose, gum, carrageenan, pectin, gelatin, agar, calcium cross-linking agents, phosphate cross-linking agents, enzyme cross-linking agents or a mixture thereof, wherein the cheese mixture consists of: c) 50-80% by weight Mozzarella cheese; and d) 20-50% by weight Emmental cheese.
    Type: Application
    Filed: August 14, 2007
    Publication date: October 30, 2008
    Inventors: Roberto di Domenico, Sandro Panaioli, Massimiliano Treggiari
  • Patent number: 6313333
    Abstract: The present invention relates to tetra- and penta-nuclear platinum complexes with antitumor activity, to a method for preparing them and to pharmaceutical compositions containing them.
    Type: Grant
    Filed: April 27, 2000
    Date of Patent: November 6, 2001
    Assignee: Setanta Therapeutics, Inc.
    Inventors: Giovanni Da Re, Roberto Di Domenico, Silvano Spinelli, Nicholas Farrell
  • Patent number: 6200989
    Abstract: Compounds of the formula wherein R,R′, A,B,T and x have the meaning given in the specification possess uPA (urokinase-type plasminogen activator) antagonist activity and can be employed as antitumor and/or antimetastatic agents.
    Type: Grant
    Filed: September 22, 1999
    Date of Patent: March 13, 2001
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Gianpiero De Cillis, Roberto Di Domenico, Bernhard Könic, Ambrogio Oliva
  • Patent number: 6060616
    Abstract: Bis-platinum(II) complexes with polymethylene derivatives, the method of making the complexes, and the use of the complexes for the treatment of tumors in mammals, are disclosed. The method of making the polymethylene derivatives, is also disclosed.
    Type: Grant
    Filed: October 14, 1998
    Date of Patent: May 9, 2000
    Assignees: Hoffmann-La Roche Inc., Virginia Commonwealth University
    Inventors: Nicholas P. Farrell, Erneston Menta, Roberto Di Domenico, Silvano Spinelli
  • Patent number: 6022892
    Abstract: Bis-platinum(II) complexes with polyamine ligands, including spermidine and spermine, are disclosed. The method of making the bis-platinum(II) complexes, using a DMF complex, and the use of the bis-platinum complexes for the treatment of tumors in mammals are also disclosed. The method of making the polyamine ligands and the use of a new polyamine compound as an intermediate in the synthesis of polyamine ligands are also disclosed.
    Type: Grant
    Filed: February 22, 1998
    Date of Patent: February 8, 2000
    Assignees: Hoffman-La Roche Inc., Virginia Commonwealth University
    Inventors: Nicholas P. Farrell, Ernesto Menta, Roberto Di Domenico, Silvano Spinelli
  • Patent number: 5453423
    Abstract: Compounds of the formula ##STR1## wherein A, Y, X, B and D are described in the specification are disclosed. The compounds possess activity in treating asthma and other pathologies of the respiratory tract.
    Type: Grant
    Filed: September 27, 1993
    Date of Patent: September 26, 1995
    Assignee: Boehringer Mannheim Italia S.p.A.
    Inventors: Giorgio Long, Carmelo A. Gandolfi, Gianpiero De Cillis, Roberto Di Domenico, Antonella Rozzi, Licia Gallico
  • Patent number: 5212316
    Abstract: Compounds of formula I ##STR1## wherein Ar is an optionally substituted phenyl ring; B is a single bond, a group --(CH.sub.2 OCH.sub.2).sub.n being n=or 2, a a 2,4-disubstituted-1,3-dioxolane ring or a 2,4-disubstituted-1,3-thioxolane ring, R is a single bond, an optionally substituted methylene or ethylene group and T is 2, 3- or 4-pyridyl, an optionally salified or esterified carboxy group or a carboxyamide group. Said compounds are useful in treatment of respiratory diseases.
    Type: Grant
    Filed: July 30, 1990
    Date of Patent: May 18, 1993
    Assignee: Boehringer Mannheim Italia
    Inventors: Silvano Spinelli, Roberto Di Domenico, Ernesto Menta, Bruno Lumachi, Licia Gallico, Sergio Tognella
  • Patent number: 5206254
    Abstract: This application relates to compounds of formula I; ##STR1## wherein R is hydrogen, a linear or branched C.sub.1 -C.sub.4 -alkyl, allyl or propargyl; X is O, CH.sub.2 or S; R.sub.1 is --(CH.sub.2).sub.n Ra, hydroxy, --O--(CH.sub.2).sub.n Ra, --NRbRc or --NH c(CH.sub.2).sub.m --NRbRc; Ra is hydrogen, a linear or branched C.sub.1 -CH.sub.4 -alkyl, phenyl, p-methoxy-phenyl, 3,4,5-trimethoxyphenyl, B-pyryidyl, cyclopentyl or cyclohexyl; Rb and Rc, can be the same or different and are selected independently in the group of hydrogen, linear or branched C.sub.1 -C.sub.4 -alkyl, cyclohexyl, cyclopentyl, benzyl, hexahydrobenzyl, .alpha.,.beta. or .gamma.-pyridylmethyl; or Rb and Rc taken together with the N atom to which they are bound can form a morpholino, piperidino or piperazino residue of formula Rd--N(CH.sub.2 --CH.sub.2).sub.2 --N-- wherein Rd is hydrogen, linear or branched C.sub.1 -C.sub.4 -alkyl, benzyl, hexahydrobenzyl, (C.sub.6 H.sub.5).sub.2 CH--, (p--F--C.sub.6 H.sub.4).sub.
    Type: Grant
    Filed: October 29, 1990
    Date of Patent: April 27, 1993
    Assignee: Boehringer Mannheim Italia S.p.A.
    Inventors: Carmelo A. Gandolfi, Roberto Di Domenico, Silvano Spinelli, Licia Gallico, Bruno Lumachi, Sergio Tognella
  • Patent number: 4988701
    Abstract: Cyclic amino-thioacetal amides of formula I ##STR1## wherein X is O, S, p is 1 or 2, R and R.sub.1 are optionally esterified hydrogen or carboxy, A is a single bond, methylene or ethylene, m is zero or 1, n is an integer 1 to 7 and y is a imidazole or .beta.-pyridylmethyl residue.Compounds I have valuable therapeutic properties.
    Type: Grant
    Filed: December 15, 1989
    Date of Patent: January 29, 1991
    Assignee: Boehringer Biochemia Robin S.p.A.
    Inventors: Roberto Di Domenico, Carmelo A. Gandolfi, Silvano Spinelli, Bruno Lumachi, Odoardo Tofanetti, Sergio Tognella
  • Patent number: 4968706
    Abstract: Compounds of formula I ##STR1## wherein Ar is an optionally substituted phenyl ring; B is a single bond, a group --(CH.sub.2 OCH.sub.2).sub.n being n=1 or 2, a 2,4-disubstituted-1,3-dioxolane ring or a 2,4-disubstituted-1,3-thioxolane ring, R is a single bond, an optionally substituted methylene or ethylene group and T is 2-, 3- or 4-pyridyl, an optionally salified or esterified carboxy group or a carboxyamide group. Said compounds are useful in treatment of respiratory diseases.
    Type: Grant
    Filed: August 11, 1988
    Date of Patent: November 6, 1990
    Assignee: Boehringer Mannhein Italia, S.p.A.
    Inventors: Silvano Spinelli, Roberto Di Domenico, Ernesto Menta, Bruno Lumachi, Licia Gallico, Sergio Tognella
  • Patent number: 4849437
    Abstract: Thiazolidines of formula I ##STR1## wherein R is H, C.sub.1 -C.sub.4 -alkyl, allyl or propargyl;X is O, CH.sub.2, S;R.sub.1 is C.sub.1 -C.sub.6 -linear or branched alkyl, phenyl, benzyl, or a group of formula CH.sub.2 --CH.sub.2 --O--(CH.sub.2 --CH.sub.2 --O).sub.n --Ra wherein n is zero or an integer from 1 to 3 and Ra is H, benzyl or C.sub.1 -C.sub.6 -linear or branched alkyl.Compounds I are endowed with favourable therapeutical properties for pathologies of the respiratory system.
    Type: Grant
    Filed: April 14, 1988
    Date of Patent: July 18, 1989
    Assignee: Boehringer Biochemia Robin S.p.A.
    Inventors: Roberto Di Domenico, Daniele Castoldi, Silvano Spinelli, Odoardo Tofanetti, Sergio Tognella, Carmelo A. Gandolfi