Patents by Inventor Roberto Fanelli

Roberto Fanelli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS FOR THE PREPARATION OF PANOBINOSTAT
    Publication number: 20230070370
    Abstract: The present invention relates to a new process for the preparation of Panobinostat and intermediates thereof.
    Type: Application
    Filed: February 25, 2021
    Publication date: March 9, 2023
    Applicants: FLAMMA SPA, UNIVERSITÀ DEGLI STUDI DI PAVIA
    Inventors: Massimiliano ANDREOLI, Teresa BASILE, Alessio PORTA, Giuseppe ZANONI, Roberto FANELLI, Massimo VERZINI
  • METHOD FOR THE INDUSTRIAL PREPARATION OF THE DISODIUM SALT OF ((2S)-3-([1,1'-BIPHENYL]-4-YL)-2-((HYDROXY((1R)-1-(((1-(ISOBUTYRYLOXY)ETHOXY)CARBONYL)AMINO)ETHYL)PHOSPHORYL) METHYL)PROPANOYL)-L-ALANINE
    Publication number: 20230041504
    Abstract: The present invention relates to a method for the industrial preparation of ((2S)-3-([1,1?-biphenyl]-4-yl)-2-((((R)-1-aminoethyl)(hydroxy)phosphoryl)methyl)propanoyl)-L-alanine acid of following formula (E): from (S)-1-phenylethylamine via a multi-step synthesis. The present invention pertains to a method for the industrial preparation of the disodium salt of ((2S)-3-([1,1?-biphenyl]-4-yl)-2-((hydroxy((1R)-1-(((1-(isobutyryloxy)ethoxy)carbonyl)amino)ethyl)phosphoryl)methyl)propanoyl)-L-alanine of following formula (I): in two additional steps from the compound (E) such as defined above. The present invention also pertains to a method for diastereoisomeric enrichment of the intermediates of the method for the industrial preparation of the compound of formula (E) of the present invention.
    Type: Application
    Filed: December 11, 2020
    Publication date: February 9, 2023
    Inventors: Hervé Poras, Alain Priour, Guillaume Grach, Roberto Fanelli, Xinjun Zhao