Patents by Inventor Roberto Fernandez-Lafuente

Roberto Fernandez-Lafuente has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Biosensor with inorganic-organic hybrid polymer coating
    Patent number: 7709221
    Abstract: The present invention relates to a biosensor comprising a substrate with a coating system in which a Ruthenium complex and an enzyme is integrated. The enzyme is able to convert bioproducts, e.g. glucose, fructose or glycerol. The depletion of oxygen during these converting reactions can be monitored via the fluorescence of the Ruthenium complex. The inventive biosensor can be used in biotechnological processes, e.g. the synthesis of biofuels.
    Type: Grant
    Filed: November 14, 2006
    Date of Patent: May 4, 2010
    Assignees: Fraunhofer Gesellschaft zur Forderung der angewandten Forschung e.V., Institute of Catalysis, Ecole Centrale de Lyon
    Inventors: Klaus Rose, Roberto Fernandez Lafuente, Jose Manuel Guisan, Lorena Betancor, Nicole Jaffrezic, Sergei Dzyadevych
  • Optically active carbonates as precursors of (+)-zopiclone
    Patent number: 6969767
    Abstract: In the present invention new compounds of formula II, in enantiomerically enriched forms, are described for the first time, where R1 is chloroalkyl. The present invention also includes several new enzymatic processes for the resolution of the enantiomers of the aforementioned carbonates of formula II from the corresponding racemic mixture. The transformation of these carbonates into zopiclone enantiomerically enriched, constitutes an additional aspect of the invention.
    Type: Grant
    Filed: April 2, 2003
    Date of Patent: November 29, 2005
    Assignees: Universidad de Oviedo, Astur Pharma, S.A.
    Inventors: Miguel Bayod Jasanada, Victor M. Sanchez Pedregal, Vicente Gotor Santamaria, M. Rosario Brieva Collado, Laura Fernandez Solares, Monica Diaz Sierra, Jose Manuel Guisan Seijas, Jose Miguel Palomo Carmona, Roberto Fernandez-Lafuente
  • Method for the synthesis of semi-synthetic antibiotics in thermodynamically controlled water-cosolvent organic miscible apolar systems by using penicillin G acylase
    Patent number: 5268271
    Abstract: Synthesis of semi-synthetic monobactamic or .beta.-Lactamic antibiotics by using derivatives stabilized by various methods of penicillin G acylase from various microbial sources according to a thermodynamically controlled strategy in monophase water/cosolvent organic apolar systems, wherein the concentration of the cosolvent varies between 30% and 90%, the temperature between -10.degree. C. and 50.degree. C., the pH between 4.5 and 8.5, with concentrations of the antibiotic nucleus between 0.5 an 875 mM and acyl donor between 0.2 mM and 1M, with a relationship antibiotic ring/activated or free acyl donor, using a buffer between 0 and 1M. Application to the pharmaceutical industry.
    Type: Grant
    Filed: August 2, 1991
    Date of Patent: December 7, 1993
    Assignee: Cosejo Superior de Invetigaciones Certificas
    Inventors: Jose M. Guisan Seijas, Roberto Fernandez Lafuente, Gregorio Alvaro Campos, Rosa M. Blanco Martin, Cristina Molina Rosell