Patents by Inventor Roberto Guerrieri

Roberto Guerrieri has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10571475
    Abstract: Methods and systems for rapid and efficient screening of monoclonal antibodies and antibody-secreting cells, and particularly of single antibody-secreting cells, for both primary and functional characteristics, and particularly cell to cell interactions, in a microfluidic system, in particular an inverted open microwell system, where the particle(s) is not bound to a substrate.
    Type: Grant
    Filed: December 5, 2011
    Date of Patent: February 25, 2020
    Assignee: Cellply S.R.L.
    Inventors: Massimo Bocchi, Roberto Guerrieri
  • Patent number: 10012579
    Abstract: An inverted microwell provides rapid and efficient microanalysis system and method for screening of biological particles, particularly functional analysis of cells on a single cell basis. The use of an inverted open microwell system permits identification of particles, cells, and biomolecules that may be combined to produce a desired functional effect also functional screening of secreted antibody therapeutic activity as well as the potential to recover cells and fluid, and optionally expand cells, such as antibody secreting cells, within the same microwell.
    Type: Grant
    Filed: November 13, 2017
    Date of Patent: July 3, 2018
    Assignee: CELLPLY S.R.L.
    Inventors: Massimo Bocchi, Roberto Guerrieri
  • Publication number: 20180143124
    Abstract: An inverted microwell provides rapid and efficient microanalysis system and method for screening of biological particles, particularly functional analysis of cells on a single cell basis. The use of an inverted open microwell system permits identification of particles, cells, and biomolecules that may be combined to produce a desired functional effect also functional screening of secreted antibody therapeutic activity as well as the potential to recover cells and fluid, and optionally expand cells, such as antibody secreting cells, within the same microwell.
    Type: Application
    Filed: November 13, 2017
    Publication date: May 24, 2018
    Inventors: Massimo Bocchi, Roberto Guerrieri
  • Patent number: 9891157
    Abstract: An inverted microwell (102) provides rapid and efficient microanalysis system (100) and method for screening of biological particles (128), particularly functional analysis of cells on a single cell basis. The use of an inverted open microwell system (102) permits identification of particles, cells, and biomolecules that may be combined to produce a desired functional effect also functional screening of secreted antibody therapeutic activity as well as the potential to recover cells and fluid, and optionally expand cells, such as antibody secreting cells, within the same microwell.
    Type: Grant
    Filed: December 5, 2011
    Date of Patent: February 13, 2018
    Assignee: CELLPLY S.R.L.
    Inventors: Massimo Bocchi, Roberto Guerrieri
  • Patent number: 9816910
    Abstract: An inverted microwell provides rapid and efficient microanalysis system and method for screening of biological particles, particularly functional analysis of cells on a single cell basis. The use of an inverted open microwell system permits identification of particles, cells, and biomolecules that may be combined to produce a desired functional effect also functional screening of secreted antibody therapeutic activity as well as the potential to recover cells and fluid, and optionally expand cells, such as antibody secreting cells, within the same microwell.
    Type: Grant
    Filed: February 5, 2016
    Date of Patent: November 14, 2017
    Assignee: CELLPLY S.R.L
    Inventors: Massimo Bocchi, Roberto Guerrieri
  • Patent number: 9528981
    Abstract: The invention proposes a novel therapeutic and diagnostic methodology based on the use of effector cells (for example CTL and NK cells) selected for being able to induce lysis in target cells. In particular, the invention teaches how to select strains of effector cells of the immune system according to their lytic properties. It also teaches how diagnostic procedures for checking the activity of therapeutic vaccines can be improved with respect to what shown. Finally, it shows how cell therapies used at present can be improved by using this approach.
    Type: Grant
    Filed: April 12, 2007
    Date of Patent: December 27, 2016
    Assignee: Menarini Silicon Biosystems S.p.A.
    Inventors: Roberto Gambari, Roberto Guerrieri
  • Publication number: 20160178502
    Abstract: An inverted microwell provides rapid and efficient microanalysis system and method for screening of biological particles, particularly functional analysis of cells on a single cell basis. The use of an inverted open microwell system permits identification of particles, cells, and biomolecules that may be combined to produce a desired functional effect also functional screening of secreted antibody therapeutic activity as well as the potential to recover cells and fluid, and optionally expand cells, such as antibody secreting cells, within the same microwell.
    Type: Application
    Filed: February 5, 2016
    Publication date: June 23, 2016
    Inventors: Massimo Bocchi, Roberto Guerrieri
  • Patent number: 9310334
    Abstract: Methods and apparatus are described for the processing (for example washing, incubation, etc.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: April 12, 2016
    Assignee: SILICON BIOSYSTEMS S.P.A.
    Inventors: Nicolò Manaresi, Roberto Guerrieri, Gianni Medoro
  • Patent number: 9147636
    Abstract: A method includes communicatively coupling first and second integrated electronic devices together through a plurality of reference capacitors, transmitting a plurality of transmission reference signals on transmission reference electrodes of the plurality of reference capacitors, receiving coupling signals on reception reference electrodes of the plurality of reference capacitors, amplifying said coupling signals, generating a plurality of reception reference signals, generating a plurality of reception control signals as a function of the plurality of reception reference signals, and detecting a possible misalignment between said first and second integrated electronic devices based on the plurality of reception control signals.
    Type: Grant
    Filed: November 14, 2011
    Date of Patent: September 29, 2015
    Assignee: STMicroelectronics S.r.l.
    Inventors: Roberto Canegallo, Mauro Scandiuzzo, Eleonora Franchi Scarselli, Antonio Gnudi, Roberto Guerrieri
  • Publication number: 20150224496
    Abstract: A method for using a well, in particular a well open at an upper end and having a vertical axis, able to contain a liquid and particles contained in said liquid, includes the use of said well in a normal configuration with said upper end facing upwards, and in an overturned configuration with said upper end facing downwards in which a liquid is retained in the well by capillarity.
    Type: Application
    Filed: April 20, 2015
    Publication date: August 13, 2015
    Inventors: Roberto Guerrieri, Massimo Bocchi
  • Patent number: 9039883
    Abstract: A well, in particular an open well (14) with an upper end having a vertical axis (101), for containing a liquid and particles contained within said liquid, characterized by comprising at least two manipulation electrodes (1, 2, 3, 31, 32, 36, 17, 40, 41) able to be powered by electrical voltages, in particular alternating electrical voltages, so as to manoeuvre particles within the well by means of the dielectrophoretic effect. A platform comprising a plurality of wells as described above and a method for using said well.
    Type: Grant
    Filed: May 31, 2007
    Date of Patent: May 26, 2015
    Assignee: CELLPLY S.R.L.
    Inventors: Roberto Guerrieri, Massimo Bocchi
  • Publication number: 20150136607
    Abstract: Methods and apparatus are described for the processing (for example washing, incubation, etc.
    Type: Application
    Filed: December 19, 2014
    Publication date: May 21, 2015
    Inventors: Nicolò Manaresi, Roberto Guerrieri, Gianni Medoro
  • Patent number: 8992754
    Abstract: The present invention relates to a method and an apparatus for the characterization and/or the counting of particles by means of non uniform, time variable force fields and integrated optical or impedance meter sensors. The force fields can be of positive or negative dielectrophoresis, electrophoresis or electro-hydrodynamic motions, characterized by a set of stable equilibrium points for the particles (solid, liquid or gaseous); the same method is suitable for the manipulation of droplets (liquid particles) by exploiting effects known to the international scientific community with the name of Electro-wetting on dielectric.
    Type: Grant
    Filed: February 20, 2014
    Date of Patent: March 31, 2015
    Assignee: Silicon Biosystems S.p.A.
    Inventors: Nicolò Manaresi, Roberto Guerrieri, Gianni Medoro
  • Publication number: 20140246320
    Abstract: The present invention relates to a method and an apparatus for the characterization and/or the counting of particles by means of non uniform, time variable force fields and integrated optical or impedance meter sensors. The force fields can be of positive or negative dielectrophoresis, electrophoresis or electro-hydrodynamic motions, characterized by a set of stable equilibrium points for the particles (solid, liquid or gaseous); the same method is suitable for the manipulation of droplets (liquid particles) by exploiting effects known to the international scientific community with the name of Electro-wetting on dielectric.
    Type: Application
    Filed: February 20, 2014
    Publication date: September 4, 2014
    Applicant: SILICON BIOSYSTEMS S.P.A.
    Inventors: Nicolò Manaresi, Roberto Guerrieri, Gianni Medoro
  • Patent number: 8679315
    Abstract: The present invention relates to a method and an apparatus for the characterization and/or the counting of particles by means of non uniform, time variable force fields and integrated optical or impedance meter sensors. The force fields can be of positive or negative dielectrophoresis, electrophoresis or electro-hydrodynamic motions, characterized by a set of stable equilibrium points for the particles (solid, liquid or gaseous); the same method is suitable for the manipulation of droplets (liquid particles) by exploiting effects known to the international scientific community with the name of Electro-wetting on dielectric.
    Type: Grant
    Filed: March 22, 2006
    Date of Patent: March 25, 2014
    Assignee: Silicon Biosystems S.p.A.
    Inventors: Nicolò Manaresi, Roberto Guerrieri, Gianni Medoro
  • Publication number: 20130261021
    Abstract: An inverted microwell (102) provides rapid and efficient microanalysis system (100) and method for screening of biological particles (128), particularly functional analysis of cells on a single cell basis. The use of an inverted open microwell system (102) permits identification of particles, cells, and biomolecules that may be combined to produce a desired functional effect also functional screening of secreted antibody therapeutic activity as well as the potential to recover cells and fluid, and optionally expand cells, such as antibody secreting cells, within the same microwell.
    Type: Application
    Filed: December 5, 2011
    Publication date: October 3, 2013
    Applicant: MINDSEEDS LABORATORIES S.R.L.
    Inventors: Massimo Bocchi, Roberto Guerrieri
  • Publication number: 20130252258
    Abstract: Methods and systems for rapid and efficient screening of monoclonal antibodies and antibody-secreting cells, and particularly of single antibody-secreting cells, for both primary and functional characteristics, and particularly cell to cell interactions, in a microfluidic system, in particular an inverted open microwell system, where the particle(s) is not bound to a substrate.
    Type: Application
    Filed: December 5, 2011
    Publication date: September 26, 2013
    Applicant: MINDSEEDS LABORATORIES S.R.L.
    Inventors: Massimo Bocchi, Roberto Guerrieri
  • Publication number: 20130001547
    Abstract: A method includes communicatively coupling first and second integrated electronic devices together through a plurality of reference capacitors, transmitting a plurality of transmission reference signals on transmission reference electrodes of the plurality of reference capacitors, receiving coupling signals on reception reference electrodes of the plurality of reference capacitors, amplifying said coupling signals, generating a plurality of reception reference signals, generating a plurality of reception control signals as a function of the plurality of reception reference signals, and detecting a possible misalignment between said first and second integrated electronic devices based on the plurality of reception control signals.
    Type: Application
    Filed: November 14, 2011
    Publication date: January 3, 2013
    Applicant: STMICROELECTRONICS S.R.L.
    Inventors: Roberto Canegallo, Mauro Scandiuzzo, Eleonora Franchi Scarselli, Antonio Gnudi, Roberto Guerrieri
  • Patent number: 8340576
    Abstract: A device and method to compensate for distortions of amplitude that afflict systems for communicating through capacitive coupling. A circuit includes a first transmitter stage, a first receiver stage, and a first coupling capacitor, coupled between the first transmitter stage and the first receiver stage. The first receiver stage includes a calibration amplifier of a variable-gain type coupled between the first coupling capacitor and an output of the electronic circuit. The electronic circuit includes a reference channel formed by: a transmission calibration stage; a reception calibration stage; and a reference capacitor coupled between the transmission calibration stage and the reception calibration stage.
    Type: Grant
    Filed: June 29, 2010
    Date of Patent: December 25, 2012
    Assignee: STMicroelectronics S.r.l.
    Inventors: Roberto Canegallo, Mauro Scandiuzzo, Eleonora Franchi Scarselli, Antonio Gnudi, Roberto Guerrieri, Federico Natali
  • Patent number: 8238502
    Abstract: A communication system includes first and second independently clocked devices, comprising, for each device, a transmitter and a receiver connected to each other in a crossed way in correspondence of an inter-chip communication channel. The communication system further comprises a synchronizer in turn including at least a first and a second synchronization block, having respective input terminals connected to the receivers and respective output terminals connected to the transmitters and comprising at least: a test pattern generator that generates a programmable test pattern signal; a pattern detector to check a matching between stored and received test pattern signals and thus lock corresponding clock phases of the synchronization blocks in case of positive result of this check; and a delay block able to change the clock phases until a synchronized condition of the synchronization blocks is verified, this synchronized condition corresponding to a matching between stored and received test pattern signals.
    Type: Grant
    Filed: December 29, 2008
    Date of Patent: August 7, 2012
    Assignee: STMicroelectronics S.r.l.
    Inventors: Luca Magagni, Luca Ciccarelli, Alberto Fazzi, Roberto Canegallo, Roberto Guerrieri