Patents by Inventor ROBERTO IACONE

ROBERTO IACONE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTISENSE OLIGONUCLEOTIDES FOR MODULATING HTRA1 EXPRESSION
    Publication number: 20180002701
    Abstract: The present invention relates to antisense oligonucleotides (oligomers) that are complementary to HTRA1, leading to modulation of the expression of HTRA1. Modulation of HTRA1 expression is beneficial for a range of medical disorders, such as macular degeneration, e.g. age-related macular degeneration.
    Type: Application
    Filed: June 28, 2017
    Publication date: January 4, 2018
    Inventors: Roberto Iacone, Peter Hagedorn, Susanne Kammler, Soren Ottosen, Sindri Traustason, Heidi Hudlebusch, Lykke Pedersen
  • NEW TRIFLUOROMETHYLPROPANAMIDE DERIVATIVES
    Publication number: 20170348257
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6 and R7 are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: August 22, 2017
    Publication date: December 7, 2017
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Benoit Hornsperger, Roberto Iacone, Bernd Kuhn, Hans P. Maerki, Peter Mohr, Michael Reutlinger
  • CONVERSION OF SOMATIC CELLS TO INDUCED REPROGRAMMED NEURAL STEM CELLS (IRNSCS)
    Publication number: 20160369234
    Abstract: This application relates to a method for converting somatic cells to Neural Stem Cells (NSCs). Moreover this application relates to a method for converting human fibroblasts, keratinocytes or adipocytes to neural stem cells based on linked steps of genes transduction and chemically defined medium induction.
    Type: Application
    Filed: February 18, 2016
    Publication date: December 22, 2016
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Klaus Christensen, Martin Graf, Roberto Iacone, Ravi Jagasia
  • SMALL MOLECULE BASED CONVERSION OF SOMATIC CELLS INTO NEURAL CREST CELLS
    Publication number: 20160369233
    Abstract: This application relates to a method for differentiating somatic cells into multi-competent neural crest cells based on linked steps of chemically defined medium inductions. Neural crest cells are able to differentiate into numerous cell types like Schwann cells, chondrocytes, smooth muscle cells or adipocytes.
    Type: Application
    Filed: January 22, 2016
    Publication date: December 22, 2016
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Martin Graf, Roberto Iacone, Eva Christina Thoma
  • METHOD FOR DIFFERENTIATION OF PLURIPOTENT STEM CELLS INTO MULTI-COMPETENT RENAL PRECURSORS
    Publication number: 20160145578
    Abstract: This application relates to a method for differentiating pluripotent stem cells (PSCs) into multi-competent renal precursor cells expressing Six2. These renal precursor cells are able to differentiate into fully functional and fully differentiated podocytes. Moreover this application relates to a method for differentiating human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) into defined renal precursor cells expressing Six2 and podocytes based on linked steps of chemically defined medium inductions.
    Type: Application
    Filed: January 29, 2016
    Publication date: May 26, 2016
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Jacques Bailly, Osele Ciampi, Martin Graf, Roberto Iacone, Christoph Patsch
  • Conversion of somatic cells to induced reprogrammed neural stem cells (irNSCs)
    Patent number: 9297025
    Abstract: This application relates to a method for converting somatic cells to Neural Stem Cells (NSCs). Moreover this application relates to a method for converting human fibroblasts, keratinocytes or adipocytes to neural stem cells based on linked steps of genes transduction and chemically defined medium induction.
    Type: Grant
    Filed: February 18, 2013
    Date of Patent: March 29, 2016
    Assignee: HOFFMANN-LA ROCHE INC.
    Inventors: Klaus Christensen, Martin Graf, Roberto Iacone, Ravi Jagasia
  • METHOD FOR DIFFERENTIATION OF PLURIPOTENT STEM CELLS INTO VASCULAR BED CELLS
    Publication number: 20150017674
    Abstract: This application relates to a method for differentiating pluripotent stem cells (PSCs) into vascular bed cells. Moreover this application relates to a method for differentiating human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) into vascular bed cells based on linked steps of chemically defined medium inductions.
    Type: Application
    Filed: December 9, 2013
    Publication date: January 15, 2015
    Applicant: HOFFMANN-LA ROCHE INC.
    Inventors: Klaus Christensen, Martin Graf, Roberto Iacone, Christoph Patsch, Eva Christina Thoma
  • CONVERSION OF SOMATIC CELLS TO INDUCED REPROGRAMMED NEURAL STEM CELLS (IRNSCS)
    Publication number: 20140051171
    Abstract: This application relates to a method for converting somatic cells to Neural Stem Cells (NSCs). Moreover this application relates to a method for converting human fibroblasts, keratinocytes or adipocytes to neural stem cells based on linked steps of genes transduction and chemically defined medium induction.
    Type: Application
    Filed: February 18, 2013
    Publication date: February 20, 2014
    Applicant: HOFFMANN-LA ROCHE INC.
    Inventors: KLAUS CHRISTENSEN, MARTIN GRAF, ROBERTO IACONE, RAVI JAGASIA