Patents by Inventor Roberto J. Sanchez
Roberto J. Sanchez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230234935Abstract: Disclosed herein are kinase inhibitor compounds having the structure (I) or a stereoisomer, pharmaceutically acceptable salt, oxide, or solvate thereof, where R1, R2, X, L, Q, and Y are as defined herein. Also disclosed are compositions containing the kinase inhibitor compounds, methods of inhibiting activity of a kinase in a cell, methods of increasing cell proliferation in a population of pancreatic beta cells, methods of treating a subject for a condition associated with insufficient insulin secretion, and methods of treating a subject for a neurological disorder.Type: ApplicationFiled: June 25, 2021Publication date: July 27, 2023Inventors: Robert J. DEVITA, Chalada SUEBSUWONG, Kunal KUMAR, Roberto J. SANCHEZ, Andrew F. STEWART, Peng WANG, Michael B. LAZARUS
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Publication number: 20220162182Abstract: Disclosed herein are kinase inhibitor compounds having structure (I), or a stereoisomer, pharmaceutically acceptable salt, oxide, or solvate thereof, where R1, R2, R3, R4, R5, R6, R7, X, Y, Z, and (AA) are as defined herein. Also disclosed are compositions containing the kinase inhibitor compounds, methods of inhibiting activity of a kinase in a cell, methods of increasing cell proliferation in a population of pancreatic beta cells, methods of treating a subject for a condition associated with insufficient insulin secretion, and methods of treating a subject for a neurological disorder.Type: ApplicationFiled: December 31, 2019Publication date: May 26, 2022Inventors: Robert J. DEVITA, Andrew F. STEWART, Chalada SUEBSUWONG, Kunal KUMAR, Peng WANG, Roberto J. SANCHEZ, Hui WANG
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Publication number: 20220064146Abstract: Disclosed are kinase inhibitor compounds having the following structure: (I), or a stereoisomer, pharmaceutically acceptable salt, oxide, or solvate thereof, where R1, R2, R3, R4, R5, R6, N—Ar, X, Y, Z, and AA are as defined herein. Also disclosed are compositions containing the kinase inhibitor compounds, methods of inhibiting activity of a kinase in a cell, methods of increasing cell proliferation in a population of pancreatic beta cells, methods of treating a subject for a condition associated with insufficient insulin secretion, and methods of treating a subject for a neurological disorder.Type: ApplicationFiled: December 31, 2019Publication date: March 3, 2022Inventors: Robert J. DEVITA, Andrew F. STEWART, Chalada SUEBSUWONG, Kunal KUMAR, Peng WANG, Roberto J. SANCHEZ, Hui WANG
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Patent number: 8397551Abstract: A passive blast pressure sensor for detecting blast overpressures of at least a predetermined minimum threshold pressure. The blast pressure sensor includes a piston-cylinder arrangement with one end of the piston having a detection surface exposed to a blast event monitored medium through one end of the cylinder and the other end of the piston having a striker surface positioned to impact a contact stress sensitive film that is positioned against a strike surface of a rigid body, such as a backing plate. The contact stress sensitive film is of a type which changes color in response to at least a predetermined minimum contact stress which is defined as a product of the predetermined minimum threshold pressure and an amplification factor of the piston. In this manner, a color change in the film arising from impact of the piston accelerated by a blast event provides visual indication that a blast overpressure encountered from the blast event was not less than the predetermined minimum threshold pressure.Type: GrantFiled: April 30, 2010Date of Patent: March 19, 2013Assignee: Lawrence Livermore National Security, LLCInventors: Michael J. King, Roberto J. Sanchez, William C. Moss
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Publication number: 20100275676Abstract: A passive blast pressure sensor for detecting blast overpressures of at least a predetermined minimum threshold pressure. The blast pressure sensor includes a piston-cylinder arrangement with one end of the piston having a detection surface exposed to a blast event monitored medium through one end of the cylinder and the other end of the piston having a striker surface positioned to impact a contact stress sensitive film that is positioned against a strike surface of a rigid body, such as a backing plate. The contact stress sensitive film is of a type which changes color in response to at least a predetermined minimum contact stress which is defined as a product of the predetermined minimum threshold pressure and an amplification factor of the piston. In this manner, a color change in the film arising from impact of the piston accelerated by a blast event provides visual indication that a blast overpressure encountered from the blast event was not less than the predetermined minimum threshold pressure.Type: ApplicationFiled: April 30, 2010Publication date: November 4, 2010Inventors: Michael J. King, Roberto J. Sanchez, William C. Moss
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Patent number: 7149821Abstract: In an environment employing a fabric, such as a cascading switch network, a predictable input/output (I/O) configuration is provided. The I/O configuration explicitly specifies the one or more peripheral units accessible by a program, such as an operating system. Other peripheral units not specified in the I/O configuration are not accessible, thus, providing a secure environment.Type: GrantFiled: January 29, 2003Date of Patent: December 12, 2006Assignee: International Business Machines CorporationInventors: Frank W. Brice, Jr., Scott M. Carlson, John R. Flanagan, Charles W. Gainey, Jr., Eugene P. Hefferon, Jeffrey P. Kubala, Kenneth J. Oakes, Roberto J. Sanchez, Charles E. Shapley, Kenneth M. Trowell, Harry M. Yudenfriend
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Patent number: 7134219Abstract: A lightweight, small size, high sensitivity gauge for indirectly measuring displacement or absolute gap width by measuring axial strain in an orthogonal direction to the displacement/gap width. The gap gauge includes a preferably titanium base having a central tension bar with springs connecting opposite ends of the tension bar to a pair of end connector bars, and an elongated bow spring connected to the end connector bars with a middle section bowed away from the base to define a gap. The bow spring is capable of producing an axial strain in the base proportional to a displacement of the middle section in a direction orthogonal to the base. And a strain sensor, such as a Fabry-Perot interferometer strain sensor, is connected to measure the axial strain in the base, so that the displacement of the middle section may be indirectly determined from the measurement of the axial strain in the base.Type: GrantFiled: May 18, 2005Date of Patent: November 14, 2006Assignee: The Regents of the University of CaliforniaInventors: Billy E. Wood, Scott E. Groves, Greg J. Larsen, Roberto J. Sanchez
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Publication number: 20040148442Abstract: In an environment employing a fabric, such as a cascading switch network, a predictable input/output (I/O) configuration is provided. The I/O configuration explicitly specifies the one or more peripheral units accessible by a program, such as an operating system. Other peripheral units not specified in the I/O configuration are not accessible, thus, providing a secure environment.Type: ApplicationFiled: January 29, 2003Publication date: July 29, 2004Applicant: International Business Machines CorporationInventors: Frank W. Brice, Scott M. Carlson, John R. Flanagan, Charles W. Gainey, Eugene P. Hefferon, Jeffrey P. Kubala, Kenneth J. Oakes, Roberto J. Sanchez, Charles E. Shapley, Kenneth M. Trowell, Harry M. Yudenfriend
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Patent number: 6122631Abstract: A method and apparatus for providing dynamically controlling access to files in a client/server system. A client wanting access to a file first requests a token from an object server. The object server generates the token as a function of the file name and ephemeral information and provides the token to both the client and the file system. Upon receiving the token from the object server, the client presents an access request to the file system, using the token rather than the file name as an identifier. The file system compares the received identifier with the file names in the specified directory as well as with a list of valid tokens that it maintains. If the identifier corresponds to a valid token for a file in the directory, the access request is granted. Otherwise, the access request is denied. The procedure is transparent to the client, which uses the token in the same manner as it would use a regular file name.Type: GrantFiled: March 28, 1997Date of Patent: September 19, 2000Assignee: International Business Machines CorporationInventors: Robert R. Berbec, John L. Brady, James M. Caffrey, Joanne T. Crimi, Arthur P. Fenaroli, Matthew C. Iatridis, Gary S. Puchkoff, Roberto J. Sanchez, Madeline R. Whalen, Joseph A. Williams