Patents by Inventor Roberto Javier Brea Fernandez

Roberto Javier Brea Fernandez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DEPALMITOYLATING COMPOSITIONS AND THE USE THEREOF
    Publication number: 20230114304
    Abstract: Disclosed herein, inter alia, are depalmitoylating compounds, compositions, and methods of use thereof.
    Type: Application
    Filed: August 14, 2020
    Publication date: April 13, 2023
    Inventors: Neal Devaraj, Andrew Rudd, Roberto Javier Brea Fernandez
  • In situ lipid synthesis for protein reconstitution
    Patent number: 11052044
    Abstract: Described herein, inter alia, are compositions and methods useful for the reconstitution of membrane proteins.
    Type: Grant
    Filed: March 1, 2018
    Date of Patent: July 6, 2021
    Assignee: The Regents of the University of California
    Inventors: Roberto Javier Brea Fernandez, Christian Cole, Neal K. Devaraj, Brent Lyda, Roger Sunahara
  • AMPHIPHILIC THIOL COMPOUNDS AND USES THEREOF
    Publication number: 20210023065
    Abstract: Provided herein are, inter alia, amphiphilic thiol compounds and methods of using the same for the purpose of depalmitoylating proteins in cellular membranes (e.g., plasma membranes). The compounds provided herein include an amphiphilic tail, which enables them to associate with a cellular membrane and depalmitoylate (cleave native S-palmitoyl groups from) a protein in said membrane by native chemical ligation thereby triggering the protein's release from the plasma membrane. The compounds (amphiphilic thiol compounds of formula (I), (II), (III)) are, inter alia, useful for the treatment of diseases caused or associated with aberrant depalmitoylation of certain proteins (e.g., HRas, EGFR).
    Type: Application
    Filed: March 12, 2019
    Publication date: January 28, 2021
    Inventors: Roberto Javier BREA FERNANDEZ, Andrew RUDD, Neal DEVARAJ, Mai JOHNSON, Hetika VORA
  • IN SITU LIPID SYNTHESIS FOR PROTEIN RECONSTITUTION
    Publication number: 20200022915
    Abstract: Described herein, inter alia, are compositions and methods useful for the reconstitution of membrane proteins.
    Type: Application
    Filed: March 1, 2018
    Publication date: January 23, 2020
    Inventors: Roberto Javier Brea Fernandez, Christian Cole, Neal K. Devaraj, Brent Lyda, Roger Sunahara