Patents by Inventor Roberto Maldonado

Roberto Maldonado has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20140328922
    Abstract: Disclosed are methods and related compositions for concomitantly, locally administering immunosuppressants and doses of therapeutic macromolecules for reducing Type I and Type IV hypersensitivity.
    Type: Application
    Filed: May 2, 2014
    Publication date: November 6, 2014
    Applicant: Selecta Biosciences, Inc.
    Inventor: Roberto A. Maldonado
  • Publication number: 20140328854
    Abstract: Disclosed are compositions and methods that provide pharmacodynamic effects specific to therapeutic macromolecules. The effects may result from reduced doses of therapeutic macromolecules in combination with immunosuppressant doses. The effects may also be enhanced with such compositions.
    Type: Application
    Filed: May 2, 2014
    Publication date: November 6, 2014
    Applicant: Selecta Biosciences, Inc.
    Inventors: Roberto A. Maldonado, Takashi Kei Kishimoto
  • Publication number: 20140328921
    Abstract: This invention relates to methods for reducing or preventing anaphylaxis to non-allergenic antigens with compositions comprising immunosuppressants, and related compositions.
    Type: Application
    Filed: May 2, 2014
    Publication date: November 6, 2014
    Applicant: Selecta Biosciences, Inc.
    Inventor: Roberto A. Maldonado
  • Publication number: 20140328923
    Abstract: Disclosed are dosings of therapeutic macromolecules and immunosuppressants, in some embodiments attached to synthetic nanocarriers, in combination with dosings of therapeutic macromolecules without synthetic nanocarriers, and related methods that provide reduced humoral immune responses.
    Type: Application
    Filed: May 2, 2014
    Publication date: November 6, 2014
    Applicant: Selecta Biosciences, Inc.
    Inventors: Roberto A. Maldonado, Takashi Kei Kishimoto
  • Publication number: 20140199340
    Abstract: Disclosed are synthetic nanocarrier methods, and related compositions, comprising B cell and/or MHC Class II-restricted epitopes and immunosuppressants in order to generate tolerogenic immune responses, such as the generation of antigen-specific regulatory B cells.
    Type: Application
    Filed: January 22, 2014
    Publication date: July 17, 2014
    Applicant: Selecta Biosciences, Inc.
    Inventor: Roberto A. Maldonado
  • Patent number: 8652487
    Abstract: Disclosed are synthetic nanocarrier methods, and related compositions, comprising B cell and/or MHC Class II-restricted epitopes and immunosuppressants in order to generate tolerogenic immune responses, such as the generation of antigen-specific regulatory B cells.
    Type: Grant
    Filed: April 27, 2012
    Date of Patent: February 18, 2014
    Assignee: Selecta Biosciences, Inc.
    Inventor: Roberto A. Maldonado
  • Publication number: 20130195919
    Abstract: The invention provides, for example, compositions comprising induced tolerogenic dendritic cells which are capable of suppressing an antigen specific T cell-mediated immune response, and to methods of making and using the same. The invention also provides compositions comprising induced immunogenic dendritic cells and methods of making and using them.
    Type: Application
    Filed: March 7, 2011
    Publication date: August 1, 2013
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Ulrich Von Andrian, Roberto Maldonado, Fulvia Vascotto
  • Publication number: 20130058963
    Abstract: Disclosed are antigen-specific induced tolerogenic dendritic cells (itDCs) that generate CD8+ regulatory T cells, as well as related compositions and methods.
    Type: Application
    Filed: April 27, 2012
    Publication date: March 7, 2013
    Applicant: Selecta Biosciences, Inc.
    Inventors: Roberto A. Maldonado, Takashi Kei Kishimoto
  • Publication number: 20130058894
    Abstract: Disclosed are therapeutic protein-specific induced tolerogenic dendritic cells (itDCs), as well as related compositions and methods.
    Type: Application
    Filed: April 27, 2012
    Publication date: March 7, 2013
    Applicant: Selecta Biosciences, Inc.
    Inventors: Roberto A. Maldonado, Takashi Kei Kishimoto
  • Publication number: 20130058901
    Abstract: Disclosed are transplantable graft-specific induced tolerogenic dendritic cells (itDCs), as well as related compositions and methods.
    Type: Application
    Filed: April 27, 2012
    Publication date: March 7, 2013
    Applicant: Selecta Biosciences, Inc.
    Inventors: Roberto A. Maldonado, Takashi Kei Kishimoto
  • Publication number: 20130059009
    Abstract: Disclosed are antigen-specific induced tolerogenic dendritic cells (itDCs) that are produced from combining itDCs with antigen in particulate form, as well as related compositions and methods.
    Type: Application
    Filed: April 27, 2012
    Publication date: March 7, 2013
    Applicant: Selecta Biosciences, Inc.
    Inventors: Takashi Kei Kishimoto, Roberto A. Maldonado, Christopher Fraser, David H. Altreuter
  • Publication number: 20130058902
    Abstract: Disclosed are induced tolerogenic dendritic cells (itDCs) produced from dendritic cell subsets that possess a desired physiological characteristic, as well as related compositions and methods.
    Type: Application
    Filed: April 27, 2012
    Publication date: March 7, 2013
    Applicant: Selecta Biosciences, Inc.
    Inventors: Takashi Kei Kishimoto, Roberto A. Maldonado
  • Publication number: 20130058976
    Abstract: Disclosed are allergen-specific induced tolerogenic dendritic cells (itDCs), as well as related compositions and methods.
    Type: Application
    Filed: April 27, 2012
    Publication date: March 7, 2013
    Applicant: Selecta Biosciences, Inc.
    Inventors: Takashi Kei Kishimoto, Roberto A. Maldonado
  • Publication number: 20130058970
    Abstract: Disclosed are induced tolerogenic dendritic cells (itDCs), as well as related compositions and methods, for reducing systemic inflammatory cytokines.
    Type: Application
    Filed: April 27, 2012
    Publication date: March 7, 2013
    Applicant: Selecta Biosciences, Inc.
    Inventors: Takashi Kei Kishimoto, Roberto A. Maldonado
  • Publication number: 20130058978
    Abstract: Disclosed are antigen-specific induced tolerogenic dendritic cells (itDCs) that generate regulatory B cells, as well as related compositions and methods.
    Type: Application
    Filed: April 27, 2012
    Publication date: March 7, 2013
    Applicant: Selecta Biosciences, Inc.
    Inventor: Roberto A. Maldonado
  • Publication number: 20130058974
    Abstract: Disclosed are antigen-specific induced tolerogenic dendritic cells (itDCs) for reducing CD8+ T cell immune responses, as well as related compositions and methods.
    Type: Application
    Filed: April 27, 2012
    Publication date: March 7, 2013
    Applicant: Selecta Biosciences, Inc.
    Inventors: Roberto A. Maldonado, Takashi Kei Kishimoto
  • Publication number: 20130058975
    Abstract: Disclosed are antigen-specific induced tolerogenic dendritic cells (itDCs) for reducing undesired humoral immune responses, as well as related compositions and methods.
    Type: Application
    Filed: April 27, 2012
    Publication date: March 7, 2013
    Applicant: Selecta Biosciences, Inc.
    Inventors: Roberto A. Maldonado, Takashi Kei Kishimoto
  • Publication number: 20130058977
    Abstract: Disclosed are induced tolerogenic dendritic cells (itDCs) produced by combining itDCs with externally loadable MHC Class I-restricted epitopes, as well as related compositions and methods.
    Type: Application
    Filed: April 27, 2012
    Publication date: March 7, 2013
    Applicant: Selecta Biosciences, Inc.
    Inventors: Roberto A. Maldonado, Takashi Kei Kishimoto
  • Publication number: 20120301510
    Abstract: Disclosed are synthetic nanocarrier compositions, and related methods, comprising CD1d-restricted antigens and immunosuppressants that provide tolerogenic immune responses.
    Type: Application
    Filed: April 27, 2012
    Publication date: November 29, 2012
    Applicant: Selecta Biosciences, Inc.
    Inventors: Takashi Kei Kishimoto, Christopher Fraser, Roberto A. Maldonado
  • Publication number: 20120301498
    Abstract: Disclosed are synthetic nanocarrier compositions that provide controlled release of immunosuppressants as well as related methods. The synthetic nanocarrier compositions may also include antigen in some embodiments.
    Type: Application
    Filed: April 27, 2012
    Publication date: November 29, 2012
    Applicant: Selecta Biosciences, Inc.
    Inventors: David H. Altreuter, Aaron P. Griset, Roberto A. Maldonado