Patents by Inventor Roberto Melzi

Roberto Melzi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9329245
    Abstract: A method for producing hyperpolarized sample material for use in magnetic resonance investigations involves preparing a target material containing high ? nuclei with a short T1, a polarizing agent with a broad EPR line, and low ? nuclei with a long T1. The polarizing agent in the target material is irradiated with microwave radiation, wherein the target material is at a cryogenic temperature and exposed to a static magnetic field B0?4.0 T, thus polarizing the high ? nuclei by DNP, and the polarization is transferred from the high ? nuclei to the low ? nuclei by Cross Polarization. A dissolved sample material is prepared containing the hyperpolarized low ? nuclei from the target material. Nuclei with a long longitudinal relaxation time T1 can thereby be quickly hyperpolarized to a high polarization level.
    Type: Grant
    Filed: April 11, 2012
    Date of Patent: May 3, 2016
    Assignees: Bruker BioSpin AG, Ecole Polytechnique Fédérale de Lausanne (EPFL)
    Inventors: Sami Jannin, Antonio Giuseppe Gianotti, Joost Lohman, Frank Engelke, Roberto Melzi, Aurélien Bornet, Geoffrey Bodenhausen
  • Publication number: 20130274111
    Abstract: A method for producing hyperpolarized sample material for use in magnetic resonance investigations involves preparing a target material containing high ? nuclei with a short T1, a polarizing agent with a broad EPR line, and low ? nuclei with a long T1. The polarizing agent in the target material is irradiated with microwave radiation, wherein the target material is at a cryogenic temperature and exposed to a static magnetic field B0?4.0 T, thus polarizing the high ? nuclei by DNP, and the polarization is transferred from the high ? nuclei to the low ? nuclei by Cross Polarization. A dissolved sample material is prepared containing the hyperpolarized low ? nuclei from the target material. Nuclei with a long longitudinal relaxation time T1 can thereby be quickly hyperpolarized to a high polarization level.
    Type: Application
    Filed: April 11, 2012
    Publication date: October 17, 2013
    Inventors: Sami Jannin, Antonio Giuseppe Gianotti, Joost Lohman, Frank Engelke, Roberto Melzi, Aurélien Bornet, Geoffrey Bodenhausen
  • Patent number: 7271589
    Abstract: A probe head for nuclear magnetic resonance measurements in an area of a surface of a measuring object is disclosed. The probe head comprises first means for generating a static magnetic field extending at least partially parallel to the surface, second means for generating a radio frequency magnetic field having components extending perpendicular to the surface, and third means for amplifying a radio frequency magnetic field effective within the measuring object. The third means are configured as an aperture and are located between the second means and the surface.
    Type: Grant
    Filed: May 24, 2006
    Date of Patent: September 18, 2007
    Assignee: Bruker BioSpin GmbH
    Inventors: Roberto Melzi, Fabio Tedoldi, Giovanni Bizzaro
  • Publication number: 20060290352
    Abstract: A probe head for nuclear magnetic resonance measurements in an area of a surface of a measuring object is disclosed. The probe head comprises first means for generating a static magnetic field extending at least partially parallel to the surface, second means for generating a radio frequency magnetic field having components extending perpendicular to the surface, and third means for amplifying a radio frequency magnetic field effective within the measuring object. The third means are configured as an aperture and are located between the second means and the surface.
    Type: Application
    Filed: May 24, 2006
    Publication date: December 28, 2006
    Applicant: Bruker BioSpin GmbH
    Inventors: Roberto Melzi, Fabio Tedoldi, Giovanni Bizzaro