Patents by Inventor Roberto Profeta

Roberto Profeta has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SYNTHESIS OF VINYL CYCLOBUTYL INTERMEDIATES
    Publication number: 20260250233
    Abstract: Provided herein are processes for synthesizing intermediates useful in preparing Mcl-1 inhibitors. In particular, provided herein are processes for synthesizing compound F, or a salt thereof, wherein R1 and OPG2 are described herein. Compound F can be useful in synthesizing compound A1, or a salt of solvate thereof, and compound A2, or a salt of solvate thereof.
    Type: Application
    Filed: April 13, 2026
    Publication date: August 27, 2026
    Applicant: AMGEN INC.
    Inventors: Austin G. SMITH, Michael T. CORBETT, Neil Fred LANGILLE, Kyle D. BAUCOM, Peter K. DORNAN, Gabrielle ST-PIERRE, Philipp C. ROOSEN, Sheng CUI, Roberto PROFETA
  • Synthesis of vinyl cyclobutyl intermediates
    Patent number: 12623993
    Abstract: Provided herein are processes for synthesizing intermediates useful in preparing Mcl-1 inhibitors. In particular, provided herein are processes for synthesizing compound F, or a salt thereof, wherein R1 and OPG2 are described herein. Compound F can be useful in synthesizing compound A1, or a salt of solvate thereof, and compound A2, or a salt of solvate thereof.
    Type: Grant
    Filed: May 4, 2021
    Date of Patent: May 12, 2026
    Assignee: AMGEN INC.
    Inventors: Austin G. Smith, Michael T. Corbett, Neil Fred Langille, Kyle D. Baucom, Peter K. Dornan, Gabrielle St- Pierre, Philipp C. Roosen, Sheng Cui, Roberto Profeta
  • ENANTIOSELECTIVE ALKENYLATION OF ALDEHYDES
    Publication number: 20240002400
    Abstract: Provided herein are processes for synthesizing intermediates useful in preparing Mcl-1 inhibitors. In particular, provided herein are processes for synthesizing compound IA, wherein R1 is described herein. Compound IA can be useful in synthesizing compound A1, or a salt or solvate thereof, and compound A2, or a salt of solvate thereof.
    Type: Application
    Filed: November 23, 2021
    Publication date: January 4, 2024
    Applicant: AMGEN INC.
    Inventors: KYLE D. BAUCOM, MICHAEL T. CORBETT, SHENG CUI, NEIL F. LANGILLE, ANDREAS RENE ROTHELI, ROBERTO PROFETA, AUSTIN G. SMITH
  • Synthesis of Vinyl Cyclobutyl Intermediates
    Publication number: 20230183164
    Abstract: Provided herein are processes for synthesizing intermediates useful in preparing Mcl-1 inhibitors. In particular, provided herein are processes for synthesizing compound F, or a salt thereof, wherein R1 and OPG2 are described herein. Compound F can be useful in synthesizing compound A1, or a salt of solvate thereof, and compound A2, or a salt of solvate thereof.
    Type: Application
    Filed: May 4, 2021
    Publication date: June 15, 2023
    Applicant: AMGEN INC.
    Inventors: Austin G. SMITH, Michael T. CORBETT, Neil Fred LANGILLE, Kyle D. BAUCOM, Peter K. DORNAN, Gabrielle ST- PIERRE, Philipp C. ROOSEN, Sheng CUI, Roberto PROFETA
  • Process for the preparation of pure nilotinib and its salt
    Patent number: 10280153
    Abstract: Object of the present invention is a process for the preparation of the pharmaceutical active ingredient Nilotinib free base or Nilotinib dihydrochloride dihydrate by means of an improved crystallization procedure.
    Type: Grant
    Filed: May 15, 2018
    Date of Patent: May 7, 2019
    Assignee: F.I.S.—Fabbrica Italiana Sintetici S.p.A.
    Inventors: JinPu Shi, Roberto Profeta
  • PROCESS FOR THE PREPARATION OF PURE NILOTINIB AND ITS SALT
    Publication number: 20180334449
    Abstract: Object of the present invention is a process for the preparation of the pharmaceutical active ingredient Nilotinib free base or Nilotinib dihydrochloride dihydrate by means of an improved crystallization procedure.
    Type: Application
    Filed: May 15, 2018
    Publication date: November 22, 2018
    Applicant: F.I.S. - Fabbrica Italiana Sintetici S.p.A.
    Inventors: JinPu SHI, Roberto PROFETA
  • Tricyclic substituted benzenesulfonamide piperazine derivatives as CAV2.2 calcium channel blockers
    Patent number: 8933132
    Abstract: The invention relates to novel piperazine compounds of formula (I): to processes for their preparation; to pharmaceutical compositions containing the compounds; and to the use of the compounds in therapy to treat diseases for which blocking the Cav2.2 calcium channels is beneficial, i.e. in particular to treat pain.
    Type: Grant
    Filed: January 19, 2012
    Date of Patent: January 13, 2015
    Assignee: Convergence Pharmaceuticals Limited
    Inventors: David Norton, Daniele Andreotti, Simon E. Ward, Roberto Profeta, Simone Spada, Helen Susanne Price
  • PIPERAZINE DERIVATIVES AS CAV2.2 CALCIUM CHANNEL BLOCKERS
    Publication number: 20140038976
    Abstract: The invention relates to novel piperazine compounds; to processes for their preparation; to pharmaceutical compositions containing the compounds; and to the use of the compounds in therapy to treat diseases for which blocking the Cav2.2 calcium channels is beneficial, i.e. in particular to treat pain.
    Type: Application
    Filed: January 19, 2012
    Publication date: February 6, 2014
    Inventors: David Norton, Daniele Andreotti, Simon E. Ward, Roberto Profeta, Simone Spada, Helen Susanne Price
  • Method of treating epilepsy by administering 5-(4{[(2-fluorophenyl)methyl]oxy}phenyl)prolinamide
    Patent number: 8153681
    Abstract: The invention provides a compound of formula (I), a solvate, a salt or prodrug thereof, useful in the treatment of diseases and conditions mediated by modulation of use-dependent voltage-gated sodium channels. Methods of treating epilepsy in a mammal are also provided.
    Type: Grant
    Filed: December 17, 2009
    Date of Patent: April 10, 2012
    Assignee: Convergence Pharmaceuticals Limited
    Inventors: Giuseppe Alvaro, Markus Bergauer, Roberto Profeta, Riccardo Giovannini
  • Compounds
    Patent number: 8153623
    Abstract: Compounds of formula (I), pharmaceutical compositions thereof, and methods for treatment using the same.
    Type: Grant
    Filed: August 4, 2010
    Date of Patent: April 10, 2012
    Assignee: Convergence Pharmaceuticals Limited
    Inventors: Giuseppe Alvaro, David Amantini, Markus Bergauer, Francesca Bonetti, Roberto Profeta
  • Methods of treating bipolar disorders
    Patent number: 8143306
    Abstract: The invention provides a compound of formula (I), a solvate, a salt or prodrug thereof, useful in the treatment of diseases and conditions mediated by modulation of use-dependent voltage-gated sodium channels. Methods of treating and moderating one or more bipolar disorders in a mammal are also provided.
    Type: Grant
    Filed: January 4, 2011
    Date of Patent: March 27, 2012
    Assignee: Convergence Pharmaceuticals Limited
    Inventors: Giuseppe Alvaro, Markus Bergauer, Roberto Profeta, Riccardo Giovannini
  • NOVEL COMPOUNDS
    Publication number: 20110098335
    Abstract: The invention provides a compound of formula (I), a solvate, a salt or prodrug thereof, useful in the treatment of diseases and conditions mediated by modulation of use-dependent voltage-gated sodium channels.
    Type: Application
    Filed: January 4, 2011
    Publication date: April 28, 2011
    Applicant: Convergence Pharmaceuticals Limited
    Inventors: Giuseppe Alvaro, Markus Bergauer, Roberto Profeta, Riccardo Giovannini
  • NOVEL COMPOUNDS
    Publication number: 20100324022
    Abstract: Compounds of formula (I), pharmaceutical compositions thereof, and methods for treatment using the same.
    Type: Application
    Filed: August 4, 2010
    Publication date: December 23, 2010
    Applicant: GLAXO GROUP LIMITED
    Inventors: Giuseppe Alvaro, David Amantini, Markus Bergauer, Francesca Bonetti, Roberto Profeta
  • Compounds
    Patent number: 7803833
    Abstract: The invention relates to quaternary ?-aminocarboxyamide derivatives of formula (I), wherein R1, R2, R3, R4, R5, R6, X, q and n are as defined in claim 1, for treating diseases and conditions mediated by modulation of voltage-gated sodium channels.
    Type: Grant
    Filed: October 6, 2006
    Date of Patent: September 28, 2010
    Assignee: Glaxo Group Limited
    Inventors: Giuseppe Alvaro, David Amantini, Markus Bergauer, Francesca Bonetti, Roberto Profeta
  • 5-(4PHENYL)PROLINAMIDE FOR TREATMENT OF EPILEPSY
    Publication number: 20100105754
    Abstract: The invention provides a compound of formula (I), a solvate, a salt or prodrug thereof, useful in the treatment of diseases and conditions mediated by modulation of use-dependent voltage-gated sodium channels.
    Type: Application
    Filed: December 17, 2009
    Publication date: April 29, 2010
    Applicant: GLAXO GROUP LIMITED
    Inventors: Giuseppe Alvaro, Markus Bergauer, Roberto Profeta, Riccardo Giovannini
  • Compounds
    Patent number: 7655693
    Abstract: The invention provides a compound of formula (I), pharmaceutical compositions thereof, and methods of treatment using the same.
    Type: Grant
    Filed: October 6, 2006
    Date of Patent: February 2, 2010
    Assignee: Glaxo Group Limited
    Inventors: Giuseppe Alvaro, Markus Bergauer, Roberto Profeta, Riccardo Giovannini
  • Novel Compounds
    Publication number: 20080293753
    Abstract: The invention relates to quaternary ?-aminocarboxyamide derivatives of formula (I), wherein R1, R2, R3, R4, R5, R6, X, q and n are as defined in claim 1, for treating diseases and conditions mediated by modulation of voltage-gated sodium channels.
    Type: Application
    Filed: October 6, 2006
    Publication date: November 27, 2008
    Inventors: Giuseppe Alvaro, David Amantini, Markus Bergauer, Francesca Bonetti, Roberto Profeta
  • Novel Compounds
    Publication number: 20080280969
    Abstract: The invention provides a compound of formula (I), pharmaceutical compositions thereof, and methods of treatment using the same.
    Type: Application
    Filed: October 6, 2006
    Publication date: November 13, 2008
    Inventors: Giuseppe Alvaro, Markus Bergauer, Roberto Profeta, Riccardo Giovannini