Patents by Inventor Roberto Rocco Tufaro

Roberto Rocco Tufaro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nucleoside phosphoramidates useful for the treatment of viral infections and preparation thereof
    Patent number: 10407456
    Abstract: Two processes are described for preparing, in different diastereomeric purity degrees, the compound (S)-isopropyl-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)-phosphoryl)amino) propanoate, having the formula given below, known as Sofosbuvir and used for the treatment of hepatitis C.
    Type: Grant
    Filed: March 25, 2016
    Date of Patent: September 10, 2019
    Assignee: QUIMICA SINTETICA, S.A.
    Inventors: Giuseppe Barreca, Marcello Rasparini, Andrea Poggiali, Luca Carcone, Roberto Rocco Tufaro, Giovanni Marras, Maurizio Taddei, Elena Cini
  • NUCLEOSIDE PHOSPHORAMIDATES USEFUL FOR THE TREATMENT OF VIRAL INFECTIONS AND PREPARATION THEREOF
    Publication number: 20180118776
    Abstract: Two processes are described for preparing, in different diastereomeric purity degrees, the compound (S)-isopropyl-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)-phosphoryl)amino) propanoate, having the formula given below, known as Sofosbuvir and used for the treatment of hepatitis C.
    Type: Application
    Filed: March 25, 2016
    Publication date: May 3, 2018
    Inventors: Giuseppe BARRECA, Marcello RASPARINI, Andrea POGGIALI, Luca CARCONE, Roberto Rocco TUFARO, Giovanni MARRAS, Maurizio TADDEI, Elena CINI
  • Process for the production of sitagliptin
    Patent number: 8912327
    Abstract: A novel process is described for the synthesis of Sitagliptin, IUPAC name 7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1 2,4-triazolo[4,3-a]pyrazine, of formula (I).
    Type: Grant
    Filed: May 4, 2012
    Date of Patent: December 16, 2014
    Assignee: Chemo Iberica, S.A.
    Inventors: Marcello Rasparini, Roberto Rocco Tufaro, Cosima Minelli
  • PROCESS FOR THE PRODUCTION OF SITAGLIPTIN
    Publication number: 20140081026
    Abstract: A novel process is described for the synthesis of Sitagliptin, IUPAC name 7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine, of formula (I).
    Type: Application
    Filed: May 4, 2012
    Publication date: March 20, 2014
    Applicant: CHEMO IBERICA S.A.
    Inventors: Marcello Rasparini, Roberto Rocco Tufaro, Cosima Minelli