Patents by Inventor Roberto SPECK

Roberto SPECK has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR MACROPHAGE POLARIZATION
    Publication number: 20260209309
    Abstract: The present invention relates to a chimeric cytokine receptor and its use in switching the polarisation of macrophages or monocytes from M2 to M1. The present invention also relates to a method for monocyte modification to selectively increase the phagocytotic activity and to modulate the polarisation of offspring macrophages.
    Type: Application
    Filed: December 20, 2023
    Publication date: July 23, 2026
    Applicant: UNIVERSITÄT ZÜRICH
    Inventors: Simon BREDL, Roberto SPECK
  • Micro RNA expression constructs and uses thereof
    Patent number: 11649455
    Abstract: The present disclosure relates to miRNA expression constructs, such as for expression of multiple miRNAs and use thereof to knockdown target gene expression. In some aspects, the expression constructs include a promoter element, a spacer sequence and a miRNA coding sequence. In some aspects, constructs provide enhanced immune cell function.
    Type: Grant
    Filed: April 1, 2019
    Date of Patent: May 16, 2023
    Assignees: UNIVERSITY OF GENEVA, LES HÔPITAUX UNIVERSITAIRES DE GENÈVE, UNIVERSITY OF ZURICH
    Inventors: Karl-Heinz Krause, Francis Rousset, Patrick Salmon, Marco Alessandrini, Roberto Speck, Simon Bredl, Tafadzwa Mlambo, Renier Myburgh
  • Micro RNA expression constructs and uses thereof
    Patent number: 11613747
    Abstract: The present disclosure relates to miRNA expression constructs, such as for expression of multiple miRNAs and use thereof to knockdown target gene expression. In some aspects, the expression constructs include a promoter element, a spacer sequence and a miRNA coding sequence. In some aspects, constructs provide enhanced immune cell function.
    Type: Grant
    Filed: April 1, 2019
    Date of Patent: March 28, 2023
    Assignees: UNIVERSITY OF GENEVA, LES HÔPITAUX UNIVERSITAIRES DE GENÈVE, UNIVERSITY OF ZURICH
    Inventors: Karl-Heinz Krause, Francis Rousset, Patrick Salmon, Marco Alessandrini, Roberto Speck, Simon Bredl, Tafadzwa Mlambo, Renier Myburgh
  • MICRO RNA EXPRESSION CONSTRUCTS AND USES THEREOF
    Publication number: 20210095278
    Abstract: The present disclosure relates to miRNA expression constructs, such as for expression of multiple miRNAs and use thereof to knockdown target gene expression. In some aspects, the expression constructs include a promoter element, a spacer sequence and a miRNA coding sequence. In some aspects, constructs provide enhanced immune cell function.
    Type: Application
    Filed: April 1, 2019
    Publication date: April 1, 2021
    Applicants: UNIVERSITY OF GENEVA, LES HÔPITAUX UNIVERSITAIRES DE GENÈVE, UNIVERSITY OF ZURICH
    Inventors: Karl-Heinz KRAUSE, Francis ROUSSET, Patrick SALMON, Marco ALESSANDRINI, Roberto SPECK, Simon BREDL, Tafadzwa MLAMBO, Renier MYBURGH