Patents by Inventor Roberto Testi

Roberto Testi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for treating Friedreich's ataxia
    Patent number: 10442779
    Abstract: The invention provides compositions and methods useful for the treatment of Friedreich's ataxia. In some embodiments, the invention provides compositions and methods useful for inhibiting the ubiquitination of frataxin.
    Type: Grant
    Filed: September 22, 2015
    Date of Patent: October 15, 2019
    Assignee: FRATAGENE THERAPEUTICS S.R.L.
    Inventors: Roberto Testi, Ottaviano Incani, Alessandra Rufini, Gabriella DeMartino
  • Methods for treating Friedreich's ataxia with etravirine
    Patent number: 10426775
    Abstract: The disclosure provides methods for the treatment of Friedreich's ataxia (FRDA), an autosomal recessive ataxia caused by mutation of the FXN gene, by administering to a subject a therapeutically effective amount of etravirine, or a pharmaceutically acceptable salt thereof. Etravirine is demonstrated to increase the levels of frataxin precursor and intermediate and mature forms of frataxin.
    Type: Grant
    Filed: September 11, 2018
    Date of Patent: October 1, 2019
    Assignee: FRATAGENE THERAPEUTICS SRL
    Inventors: Alessandra Rufini, Giulia Alfedi, Roberto Testi
  • METHODS FOR TREATING FRIEDREICH'S ATAXIA WITH ETRAVIRINE
    Publication number: 20190076429
    Abstract: The disclosure provides methods for the treatment of Friedreich's ataxia (FRDA), an autosomal recessive ataxia caused by mutation of the FXN gene, by administering to a subject a therapeutically effective amount of etravirine, or a pharmaceutically acceptable salt thereof. Etravirine is demonstrated to increase the levels of frataxin precursor and intermediate and mature forms of frataxin.
    Type: Application
    Filed: September 11, 2018
    Publication date: March 14, 2019
    Inventors: Alessandra Rufini, Giulia Alfedi, Roberto Testi
  • Frataxin mutants
    Patent number: 9944906
    Abstract: Described herein are compositions and methods for treating Friedreich's Ataxia (FRDA). In some aspects, mutant forms of frataxin which are resistant to ubiquitination are provided. In some aspects, pharmaceutical compositions comprising mutant frataxin are provided. In further aspects, methods of using mutant frataxin are provided.
    Type: Grant
    Filed: November 12, 2015
    Date of Patent: April 17, 2018
    Assignee: FRATAGENE THERAPEUTICS S.R.L.
    Inventor: Roberto Testi
  • METHODS OF TREATING FRIEDREICH'S ATAXIA USING SRC INHIBITORS
    Publication number: 20170296540
    Abstract: In one aspect, the invention presents a method of treating Friedreich's ataxia (FRDA) by administering a therapeutically effective amount of an Src inhibitor.
    Type: Application
    Filed: June 22, 2017
    Publication date: October 19, 2017
    Applicant: Fratagene Therapeutics S.R.L.
    Inventors: Roberto Testi, Florence Malisan
  • COMPOSITIONS AND METHODS FOR TREATING FRIEDREICH'S ATAXIA
    Publication number: 20160083358
    Abstract: The invention provides compositions and methods useful for the treatment of Friedreich's ataxia. In some embodiments, the invention provides compositions and methods useful for inhibiting the ubiquitination of frataxin.
    Type: Application
    Filed: September 22, 2015
    Publication date: March 24, 2016
    Inventors: Roberto Testi, Ottaviano Incani, Alessandra Rufini, Gabriella DeMartino
  • FRATAXIN MUTANTS
    Publication number: 20160060605
    Abstract: Described herein are compositions and methods for treating Friedreich's Ataxia (FRDA). In some aspects, mutant forms of frataxin which are resistant to ubiquitination are provided. In some aspects, pharmaceutical compositions comprising mutant frataxin are provided. In further aspects, methods of using mutant frataxin are provided.
    Type: Application
    Filed: November 12, 2015
    Publication date: March 3, 2016
    Applicant: Frategene Therapeutics, LLC
    Inventor: Roberto Testi
  • Frataxin mutants
    Patent number: 9217019
    Abstract: Described herein are compositions and methods for treating Friedreich's Ataxia (FRDA). In some aspects, mutant forms of frataxin which are resistant to ubiquitination are provided. In some aspects, pharmaceutical compositions comprising mutant frataxin are provided. In further aspects, methods of using mutant frataxin are provided.
    Type: Grant
    Filed: July 27, 2011
    Date of Patent: December 22, 2015
    Assignee: Fratagene Therapeutics Ltd.
    Inventor: Roberto Testi
  • Methods for treating Friedreich's ataxia with interferon gamma
    Patent number: 8815230
    Abstract: Described herein are compositions and methods for treating Friedreich's Ataxia (FRDA) with interferon gamma. In some aspects, methods for increasing expression of frataxin in cells and for treating Friedreich's Ataxia are provided. In some additional aspects, methods increasing aconitase activity in cells are provided.
    Type: Grant
    Filed: August 30, 2011
    Date of Patent: August 26, 2014
    Inventors: Roberto Testi, Barbara Tomassini
  • Compositions and methods for treating Friedreich's Ataxia
    Patent number: 8703749
    Abstract: A method of treating Friedreich's Ataxia with compounds of formula I including pharmaceutically acceptable salts, tautomers or stereoisomers of compounds of formula Lp.
    Type: Grant
    Filed: December 7, 2010
    Date of Patent: April 22, 2014
    Inventors: Roberto Testi, Ottaviano Incani
  • Frataxin Mutants
    Publication number: 20130196932
    Abstract: Described herein are compositions and methods for treating Friedreich's Ataxia (FRDA). In some aspects, mutant forms of frataxin which are resistant to ubiquitination are provided. In some aspects, pharmaceutical compositions comprising mutant frataxin are provided. In further aspects, methods of using mutant frataxin are provided.
    Type: Application
    Filed: July 27, 2011
    Publication date: August 1, 2013
    Inventor: Roberto Testi
  • Compositions and Methods for Treating Friedreich's Ataxia with Interferon Gamma
    Publication number: 20130156734
    Abstract: Described herein are compositions and methods for treating Friedreich's Ataxia (FRDA) with interferon gamma. In some aspects, methods for increasing expression of frataxin in cells and for treating Friedreich's Ataxia are provided. In some additional aspects, methods increasing aconitase activity in cells are provided.
    Type: Application
    Filed: August 30, 2011
    Publication date: June 20, 2013
    Inventors: Roberto Testi, Barbara Tomassini
  • COMPOSITIONS AND METHODS FOR TREATING FRIEDREICH'S ATAXIA
    Publication number: 20130109658
    Abstract: A method of treating Friedreich's Ataxia with compounds of formula I including pharmaceutically acceptable salts, tautomers or stereoisomers of compounds of formula Lp.
    Type: Application
    Filed: December 7, 2010
    Publication date: May 2, 2013
    Inventors: Roberto Testi, Ottaviano Incani
  • Gd3-synthesis inhibitors for treating neuropathological disorders
    Publication number: 20040092438
    Abstract: The present invention relates to the use of GD3 synthase inhibitors for treating neuropathological disorders, in particular cerebral ischemia, traumatic damage to the brain and spinal cord, and neurodegenerative disorders, and signs, symptoms and dysfunctions associated therewith, and to a method for the preparation of pharmaceuticals for the treatment of neuropathological disorders.
    Type: Application
    Filed: July 12, 2002
    Publication date: May 13, 2004
    Inventors: Ana Martin-Villalba, Johannes Schenkel, Susanne Kleber, Roberto Testi