Patents by Inventor Robertus Franciscus Maria Van Gorcom

Robertus Franciscus Maria Van Gorcom has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Selection marker gene free recombinant strains
    Patent number: 6955909
    Abstract: The present invention discloses a selection marker free system which can be used to introduce genetic modifications to in bacteria, yeasts and fungi. The system can be employed to introduce or delete desired genes or DNA fragments in the genome of the indicated host species without leaving any undesired DNA i.e. the selection marker used for selection of transformants or other DNA used for cloning. In this way strains have been developed containing only desired genes introduced at desired chromosomal sites. Similarly, desired DNA fragments have been deleted or replaced at desired sites.
    Type: Grant
    Filed: February 26, 1999
    Date of Patent: October 18, 2005
    Assignee: DSM N.V.
    Inventors: Gerardus Cornelis Maria Selten, Bart Willem Swinkels, Robertus Franciscus Maria Van Gorcom
  • Transformed fungal strains free of selection marker
    Patent number: 6063614
    Abstract: The present invention discloses a selection marker free system which can be used to introduce genetic modifications in bacteria, yeasts and fungi. The system can be employed to introduce or delete desired genes or DNA fragments in the genome of the indicated host species without leaving any undesired DNA i.e. the selection marker used for selection of transformants or other DNA used for cloning. In this way strains have been developed containing only desired genes introduced at desired chromosomal sites. Similarly, desired DNA fragments have been deleted or replaced at desired sites.
    Type: Grant
    Filed: November 10, 1998
    Date of Patent: May 16, 2000
    Assignee: DSM N.V.
    Inventors: Gerardus Cornelius Maria Selten, Bart Willem Swinkels, Robertus Franciscus Maria Van Gorcom
  • Selection marker gene free recombinant strains: a method for obtaining them and the use of these strains
    Patent number: 6051431
    Abstract: The present invention discloses a selection marker free system which can be used to introduce genetic modifications in bacteria, yeasts and fungi. The system can be employed to introduce or delete desired genes or DNA fragments in the genome of the indicated host species without leaving any undesired DNA i.e. the selection marker used for selection of transformants or other DNA used for cloning. In this way strains have been developed containing only desired genes introduced at desired chromosomal sites. Similarly, desired DNA fragments have been deleted or replaced at desired sites.
    Type: Grant
    Filed: December 8, 1997
    Date of Patent: April 18, 2000
    Assignee: DSM N.V.
    Inventors: Gerardus Cornelius Maria Selten, Bart Willem Swinkels, Robertus Franciscus Maria Van Gorcom
  • Selection marker gene free recombinant strains: method for obtaining them and the use of these strains
    Patent number: 5876988
    Abstract: The present invention discloses a selection marker free system which can be used to introduce genetic modifications in bacteria, yeasts and fungi. The system can be employed to introduce or delete desired genes or DNA fragments in the genome of the indicated host species without leaving any undesired DNA i.e. the selection marker used for selection of transformants or other DNA used for cloning. In this way strains have been developed containing only desired genes introduced at desired chromosomal sites. Similarly, desired DNA fragments have been deleted or replaced at desired sites.
    Type: Grant
    Filed: June 23, 1997
    Date of Patent: March 2, 1999
    Assignee: Gist-brocades BV
    Inventors: Gerardus Cornelius Maria Selten, Bart Willem Swinkels, Robertus Franciscus Maria Van Gorcom