Patents by Inventor Robertus Hendriks

Robertus Hendriks has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7648761
    Abstract: The present invention relates to inorganic monolithic mouldings whose surface is coated with physi- or chemisorbed organic polymers, and to processes for the production of materials of this type. The materials according to the invention are highly suitable as sorbents for chromatography, in particular for high pressure liquid chromatography of biological materials.
    Type: Grant
    Filed: October 21, 2003
    Date of Patent: January 19, 2010
    Assignee: Merck Patent GmbH
    Inventors: Zöfre Bayram-Hahn, Klaus Unger, Robertus Hendriks, Dieter Lubda
  • Patent number: 7407812
    Abstract: The invention relates to a method and a kit for the isolation of phosphorylated peptides from complex mixtures using support materials having chelate ligands based on silica and alkaline elution buffers. In preferred embodiments, the method according to the invention enables the isolation of phosphopeptides from complex sample solutions with a reproducibly high yield and at the same time with high purity and it allows efficient ionisation and detection of the isolated phosphopeptides both by MALDI-TOF and also by ESI mass spectrometry without additional requisite method steps, such as, for example, chromatographic desalination of the sample.
    Type: Grant
    Filed: April 21, 2005
    Date of Patent: August 5, 2008
    Assignee: Merck Patent GmbH
    Inventors: Jonas Anders, Achim Schwämmle, Sven Andrecht, Robertus Hendriks, Anette Boerner, Cora Rueter
  • Publication number: 20070227974
    Abstract: The invention relates to a method and a kit for the isolation of phosphorylated peptides from complex mixtures using support materials having chelate ligands based on silica and alkaline elution buffers. In preferred embodiments, the method according to the invention enables the isolation of phosphopeptides from complex sample solutions with a reproducibly high yield and at the same time with high purity and it allows efficient ionisation and detection of the isolated phosphopeptides both by MALDI-TOF and also by ESI mass spectrometry without additional requisite method steps, such as, for example, chromatographic desalination of the sample.
    Type: Application
    Filed: April 21, 2005
    Publication date: October 4, 2007
    Inventors: Jonas Anders, Achim Schwammle, Sven Andrecht, Robertus Hendriks, Anette Boerner, Cora Rueter
  • Patent number: 7262283
    Abstract: The present invention relates to a method and a kit for the sequential extraction of proteins for the production of partial proteomes from a complete proteome. In particular, the method according to the invention, besides other partial proteomes, gives a partial proteome of proteins from the cell nucleus interior separated from proteins of the cytoskeleton and of the nuclear matrix.
    Type: Grant
    Filed: August 8, 2003
    Date of Patent: August 28, 2007
    Assignee: Merck Patent GmbH
    Inventors: Robertus Hendriks, Afsaneh Abdolzade-Bavil
  • Publication number: 20060099402
    Abstract: The present invention relates to inorganic monolithic mouldings whose surface is coated with physi- or chemisorbed organic polymers, and to processes for the production of materials of this type. The materials according to the invention are highly suitable as sorbents for chromatography, in particular for high pressure liquid chromatography of biological materials.
    Type: Application
    Filed: October 21, 2003
    Publication date: May 11, 2006
    Inventors: Zofre Bayram-Hahn, Klaus Unger, Robertus Hendriks, Dieter Lubda
  • Patent number: 6617443
    Abstract: The invention relates to a method for removing endotoxins from nucleic acids. The endotoxins are removed by pre-incubating the nucleic acids in a salt-free detergent solution and subsequent anion exchange chromatography on a tentacle anion exchanger.
    Type: Grant
    Filed: September 5, 2002
    Date of Patent: September 9, 2003
    Assignee: Merck Patent GmbH
    Inventors: Robertus Hendriks, Maria Wehsling, Andrea Lantos
  • Publication number: 20030068810
    Abstract: The invention relates to a method for removing endotoxins from nucleic acids. The endotoxins are removed by pre-incubating the nucleic acids in a salt-free detergent solution and subsequent anion exchange chromatography on a tentacle anion exchanger.
    Type: Application
    Filed: September 5, 2002
    Publication date: April 10, 2003
    Inventors: Robertus Hendriks, Maria Wehsling, Andrea Lantos
  • Patent number: 6355792
    Abstract: The invention provides a method for isolating and purifying nucleic acids from liquid samples. The method comprises using a solid carrier which is essentially made of oxide inorganic materials containing hydroxyl groups (e.g., silica gel or hydroxylapatite). The nucleic acids are bound to the carrier material in the acidic pH range while they are eluted in the alkaline pH range.
    Type: Grant
    Filed: August 2, 2000
    Date of Patent: March 12, 2002
    Assignee: Merck Patent Gesellschaft
    Inventors: Uwe Michelsen, Karl Holschuh, Robertus Hendriks