Patents by Inventor Robertus Mattheus De Pater

Robertus Mattheus De Pater has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystallization of steviol glycosides
    Patent number: 11878992
    Abstract: A method for purifying rebaudioside M, which method comprises: (a) providing a solution comprising rebaudioside M at a concentration of at least about 10 g/L and at a purity of at least about 10% by weight on a dry basis; and (b) crystallizing from the solution a high purity composition comprising rebaudioside M, thereby to purify rebaudioside M.
    Type: Grant
    Filed: August 9, 2017
    Date of Patent: January 23, 2024
    Assignee: DSM IP ASSETS B.V.
    Inventors: Igor Galaev, Robertus Mattheus De Pater
  • Method for acylating a cyclic peptide
    Patent number: 10954272
    Abstract: The present invention relates to a process for acylating cyclic peptides bearing an amino group and to the application of said process in the preparation of anidulafungin and micafungin.
    Type: Grant
    Filed: December 4, 2015
    Date of Patent: March 23, 2021
    Inventors: Robertus Mattheus De Pater, Ben De Lange
  • CRYSTALLIZATION OF STEVIOL GLYCOSIDES
    Publication number: 20190194240
    Abstract: A method for purifying rebaudioside M, which method comprises: (a) providing a solution comprising rebaudioside M at a concentration of at least about 10 g/L and at a purity of at least about 10% by weight on a dry basis; and (b) crystallizing from the solution a high purity composition comprising rebaudioside M, thereby to purify rebaudioside M.
    Type: Application
    Filed: August 9, 2017
    Publication date: June 27, 2019
    Inventors: Igor GALAEV, Robertus Mattheus DE PATER
  • Method for isolating caspofungin
    Patent number: 9828411
    Abstract: The present invention relates to a method for isolating caspofungin and to a novel crystalline form of caspofungin diacetate thus obtained.
    Type: Grant
    Filed: April 28, 2014
    Date of Patent: November 28, 2017
    Assignee: DSM Sinochem Pharmaceuticals Netherlands B.V.
    Inventors: Robertus Mattheus De Pater, Neeraj Tewari, Roop Singh Yadav
  • METHOD FOR ACYLATING A CYCLIC PEPTIDE
    Publication number: 20170327540
    Abstract: The present invention relates to a process for acylating cyclic peptides bearing an amino group and to the application of said process in the preparation of anidulafungin and micafungin.
    Type: Application
    Filed: December 4, 2015
    Publication date: November 16, 2017
    Inventors: Robertus Mattheus De Pater, Ben De Lange
  • Cyclohexapeptide
    Patent number: 9556233
    Abstract: The present invention relates to a novel cyclohexapeptide, to a method for the preparation of said cyclohexapeptide and to the use of said cyclohexapeptide.
    Type: Grant
    Filed: September 8, 2014
    Date of Patent: January 31, 2017
    Assignee: DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V.
    Inventors: Paulus Bernardus Maria Groen, Peter Philip Lankhorst, Burhan Özalp, Robertus Mattheus De Pater
  • NOVEL CYCLOHEXAPEPTIDE
    Publication number: 20160215021
    Abstract: The present invention relates to a novel cyclohexapeptide, to a method for the preparation of said cyclohexapeptide and to the use of said cyclohexapeptide.
    Type: Application
    Filed: September 8, 2014
    Publication date: July 28, 2016
    Inventors: Paulus Bernardus Maria GROEN, Peter Philip LANKHORST, Burhan ÖZALP, Robertus Mattheus DE PATER
  • METHOD FOR ISOLATING CASPOFUNGIN
    Publication number: 20160068564
    Abstract: The present invention relates to a method for isolating caspofungin and to a novel crystalline form of caspofungin diacetate thus obtained.
    Type: Application
    Filed: April 28, 2014
    Publication date: March 10, 2016
    Inventors: Robertus Mattheus DE PATER, Neeraj TEWARI, Roop SINGH YADAV
  • Method for isolating a cyclohexapeptide
    Patent number: 9056897
    Abstract: The present invention relates to a method for isolating acyclohexapeptide and to a novel crystalline form of caspofungin diacetate thus obtained.
    Type: Grant
    Filed: September 26, 2011
    Date of Patent: June 16, 2015
    Assignee: DSM SINOCHEM PHARMACEUTICALS
    Inventors: Robertus Mattheus De Pater, Dhiredj Chandre Jagesar
  • Method for the preparation of cyclopeptides
    Patent number: 9006391
    Abstract: The present invention relates to a method for preparing cyclopeptides by means of protection with a substituted boronic acid. The present invention also discloses novel boronate esters of cyclopeptides of general formula (8).
    Type: Grant
    Filed: May 6, 2010
    Date of Patent: April 14, 2015
    Assignee: DSM Sinochem Pharmaceuticals Netherlands B.V.
    Inventors: Robertus Mattheus De Pater, Dhiredj Chandre Jagesar, Thomas Van Der Does
  • Purification of caspofungin intermediates
    Patent number: 8951958
    Abstract: The present invention relates to a method for the purification of cyclopeptides of general formula (3) by means of a silicate.
    Type: Grant
    Filed: March 22, 2011
    Date of Patent: February 10, 2015
    Assignee: DSM Sinochem Pharmaceuticals Netherlands B.V.
    Inventor: Robertus Mattheus De Pater
  • METHOD FOR ISOLATING A CYCLOHEXAPEPTIDE
    Publication number: 20130184433
    Abstract: The present invention relates to a method for isolating acyclohexapeptide and to a novel crystalline form of caspofungin diacetate thus obtained.
    Type: Application
    Filed: September 26, 2011
    Publication date: July 18, 2013
    Applicant: DSM Sinochem Pharmaceuticals
    Inventors: Robertus Mattheus De Pater, Dhiredj Chandre Jagesar
  • Diamine salts of carboxylic acids
    Patent number: 8461327
    Abstract: The present invention relates to a salt of a carboxylic acid with a diamine such as 2,2?-(ethylenedioxy)diethyl amine, 3,3?-(ethylenedioxy)dipropyl amine and 2,2?-oxybis(ethylamine) and a method of preparing such salts. Preferably the carboxylic acid is a fermentation product such as clavulanic acid, mycophenolic acid or pravastatin.
    Type: Grant
    Filed: March 31, 2009
    Date of Patent: June 11, 2013
    Assignee: DSM Sinochem Pharmaceuticals Netherlands B.V.
    Inventors: Robertus Mattheus De Pater, Adrianus Antonius Cornelius Van Wijk, Piotr Wnukowski
  • PURIFICATION OF CASPOFUNGIN INTERMEDIATES
    Publication number: 20130018171
    Abstract: The present invention relates to a method for the purification of cyclopeptides of general formula (3) by means of a silicate.
    Type: Application
    Filed: March 22, 2011
    Publication date: January 17, 2013
    Applicant: DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V.
    Inventor: Robertus Mattheus De Pater
  • Method for the purification of mycophenolate mofetil
    Patent number: 8273739
    Abstract: The present invention provides a method for the preparation of mycophenolate mofetil wherein mycophenolic acid or an amine salt of mycophenolic acid is esterified with 2-morpholinoethanol, the resulting mixture is extracted into water at a pH-value between 1.0 and 3.0, and mycophenolate mofetil is back-extracted in a water-immiscible solvent at a pH-value between 3.0 and 5.0.
    Type: Grant
    Filed: June 24, 2008
    Date of Patent: September 25, 2012
    Assignee: DSM Sinochem Pharmaceuticals Netherlands B.V.
    Inventor: Robertus Mattheus De Pater
  • METHOD FOR THE PREPARATION OF CYCLOPEPTIDES
    Publication number: 20120059146
    Abstract: The present invention relates to a method for preparing cyclopeptides by means of protection with a substituted boronic acid. The present invention also discloses novel boronate esters of cyclopeptides of general formula (8).
    Type: Application
    Filed: May 6, 2010
    Publication date: March 8, 2012
    Inventors: Robertus Mattheus De Pater, Dhiredj Chandre Jagesar, Thomas Van Der Does
  • PRAVASTATIN EXTRACTION
    Publication number: 20110130450
    Abstract: The present invention provides a method for the purification of pravastatin comprising extracting a solution comprising pravastatin in a water-immiscible solvent with water at a pH value ranging from 5.0 to 7.0.
    Type: Application
    Filed: March 31, 2009
    Publication date: June 2, 2011
    Inventors: Aad Johannes Bouman, Robertus Mattheus De Pater, Piotr Wnukowski
  • DIAMINE SALTS OF CARBOXYLIC ACIDS
    Publication number: 20110028712
    Abstract: The present invention relates to a salt of a carboxylic acid with a diamine such as 2,2?-(ethylenedioxy)diethyl amine, 3,3?-(ethylenedioxy)dipropyl amine and 2,2?-oxybis(ethylamine) and a method of preparing such salts. Preferably the carboxylic acid is a fermentation product such as clavulanic acid, mycophenolic acid or pravastatin.
    Type: Application
    Filed: March 31, 2009
    Publication date: February 3, 2011
    Inventors: Robertus Mattheus De Pater, Adrianus Antonius Wijk Van, Piotr Wnukowski
  • METHOD FOR THE PURIFICATION OF MYCOPHENOLATE MOFETIL
    Publication number: 20100190785
    Abstract: The present invention provides a method for the preparation of mycophenolate mofetil wherein mycophenolic acid or an amine salt of mycophenolic acid is esterified with 2-morpholinoethanol, the resulting mixture is extracted into water at a pH-value between 1.0 and 3.0, and mycophenolate mofetil is back-extracted in a water-immiscible solvent at a pH-value between 3.0 and 5.0.
    Type: Application
    Filed: June 24, 2008
    Publication date: July 29, 2010
    Inventor: Robertus Mattheus De Pater
  • Isolation of carotenoid crystals from microbial biomass
    Patent number: 6812001
    Abstract: A process for the isolation of crystalline carotenoid compound from microbial biomass comprising disrupting the microbial cell walls, separating cellular debris from the carotenoid-containing residue, washing one member of the group consisting of the microbial biomass, the disrupted cell mass and the carotenoid-containing reside with a solvent to remove lipid, suspending the obtained carotenoid crystals in water to float the crystals, recovering the crystals and, optionally, further purifying the crystals which avoids the use of large amounts of solvent of carotenoid extraction process.
    Type: Grant
    Filed: December 20, 2001
    Date of Patent: November 2, 2004
    Assignee: DSM N.V.
    Inventors: Mieke Sibeijn, Robertus Mattheus De Pater