Patents by Inventor Robin A. Felder
Robin A. Felder has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9968283Abstract: A method and related system to, among other things, automatically infer answers to all of the ADL questions and the first four questions of the IADL in the home. The inference methods detect the relevant activities unobtrusively, continuously, accurately, objectively, quantifiably and without relying on the patient's own memory (which may be fading due to aging or an existing health condition, such as Traumatic Brain Injury (TBI)) or on a caregiver's subjective report. The methods rely on the judicious placement of a number of sensors in the subject's place of residence, including motion detection sensors in every room, the decomposition of each relevant activity into the sub-tasks involved, identification of additional sensors required to detect the relevant sub-tasks and spatial-temporal conditions between the signals of sensors to formulate the rules that will detect the occurrence of the specific activities of interest.Type: GrantFiled: November 24, 2014Date of Patent: May 15, 2018Assignee: University of Virgina Patent FoundationInventors: Majd Alwan, Robin A. Felder, Steven W. Kell, Sarah G. Wood, Michael Cvetanovich, Beverly L. Turner, J. William Holman
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Patent number: 9708664Abstract: It was determined whether SNPs in SLC4A5 are associated with salt sensitivity of blood pressure (BP). Subjects consumed an isocaloric constant diet with a randomized order of 7 days low Na+ (10 mmol/d) and 7 days high Na+ (300 mmol/d) intake. Salt sensitivity was defined as a ?7 mm Hg increase in mean arterial pressure (MAP). 35 polymorphisms in 17 candidate genes were assayed. Association analyses with salt sensitivity revealed three variants that associated with salt sensitivity, two in SLC4A5 (rs7571842, rs10177833; P<0.001), and one in GRK4 (rs1801058; P=0.020). Paradoxical changes in blood pressure in response to changes in salt intake were also found associated with a SNP for DRD2 (rs6276). In conclusion, SLC4A5 variants are strongly associated with salt sensitivity of BP in Caucasian and a DRD2 SNP is a marker for paradoxical response to salt intake.Type: GrantFiled: April 22, 2013Date of Patent: July 18, 2017Assignee: University of Virginia Patent FoundationInventors: Robin A. Felder, Robert M. Carey, John E. Jones, Pedro A. Jose, Scott M. Williams
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Patent number: 9074016Abstract: Disclosed are methods for identifying individuals predisposed to essential hypertension and related conditions such as salt sensitivity by detecting the presence of polymorphic or mutant forms of the GRK4 gene, or its expression product. Also disclosed are methods for identifying polymorphic or mutant GRK4s in individuals known to be suffering from such conditions, as well as methods and compositions for conducting drug discovery and therapeutic intervention.Type: GrantFiled: December 1, 2008Date of Patent: July 7, 2015Inventors: Robin A. Felder, Pedro Jose
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Publication number: 20150133414Abstract: It was determined whether SNPs in SLC4A5 are associated with salt sensitivity of blood pressure (BP). Subjects consumed an isocaloric constant diet with a randomized order of 7 days low Na+ (10 mmol/d) and 7 days high Na+ (300 mmol/d) intake. Salt sensitivity was defined as a ?7 mm Hg increase in mean arterial pressure (MAP). 35 polymorphisms in 17 candidate genes were assayed. Association analyses with salt sensitivity revealed three variants that associated with salt sensitivity, two in SLC4A5 (rs7571842, rs10177833; P<0.001), and one in GRK4 (rs1801058; P=0.020). Paradoxical changes in blood pressure in response to changes in salt intake were also found associated with a SNP for DRD2 (rs6276). In conclusion, SLC4A5 variants are strongly associated with salt sensitivity of BP in Caucasian and a DRD2 SNP is a marker for paradoxical response to salt intake.Type: ApplicationFiled: April 22, 2013Publication date: May 14, 2015Applicant: University of Virginia Patent FoundationInventors: Robin A. Felder, Robert M. Carey, John E. Jones, Pedro A. Jose, Scott M. Williams
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Publication number: 20150080767Abstract: A method and related system to, among other things, automatically infer answers to all of the ADL questions and the first four questions of the IADL in the home. The inference methods detect the relevant activities unobtrusively, continuously, accurately, objectively, quantifiably and without relying on the patient's own memory (which may be fading due to aging or an existing health condition, such as Traumatic Brain Injury (TBI)) or on a caregiver's subjective report. The methods rely on the judicious placement of a number of sensors in the subject's place of residence, including motion detection sensors in every room, the decomposition of each relevant activity into the sub-tasks involved, identification of additional sensors required to detect the relevant sub-tasks and spatial-temporal conditions between the signals of sensors to formulate the rules that will detect the occurrence of the specific activities of interest.Type: ApplicationFiled: November 24, 2014Publication date: March 19, 2015Inventors: Majd Alwan, Robin A. Felder, Steven W. Kell, Sarah G. Wood, Michael Cvetanovich, Beverly L. Turner, J. William Holman
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Publication number: 20150005290Abstract: To characterize the urinary exosome miRNome, microarrays were used to identify the miRNA spectrum present within urinary exosomes from ten individuals that were previously classified for their salt sensitivity status. The present application discloses distinct patterns of selected exosomal miRNA expression that were different between salt-sensitive (SS), salt-resistant (SR), and inverse salt-sensitive (ISS) individuals. These miRNAs can be useful as biomarkers either individually or as panels comprising multiple miRNAs. The present invention provides compositions and methods for identifying, diagnosing, monitoring, and treating subjects with salt sensitivity of blood pressure. The applications discloses panels of miRNAs useful for comparing profiles, and in some cases one or more of the miRNAs in a panel can be used. The miRNAs useful for distinguishing SS and SR or ISS and SR subjects. One or more of the 45 miRNAs can be used. Some of the miRNAs have not been previously reported to be circulating.Type: ApplicationFiled: June 26, 2014Publication date: January 1, 2015Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATIONInventors: Robin A. Felder, Julia Carlson, John J. Gildea
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Patent number: 8894576Abstract: A method and related system to, among other things, automatically infer answers to all of the ADL questions and the first four questions of the IADL in the home. The inference methods detect the relevant activities unobtrusively, continuously, accurately, objectively, quantifiably and without relying on the patient's own memory (which may be fading due to aging or an existing health condition, such as Traumatic Brain Injury (TBI)) or on a caregiver's subjective report. The methods rely on the judicious placement of a number of sensors in the subject's place of residence, including motion detection sensors in every room, the decomposition of each relevant activity into the sub-tasks involved, identification of additional sensors required to detect the relevant sub-tasks and spatial-temporal conditions between the signals of sensors to formulate the rules that will detect the occurrence of the specific activities of interest.Type: GrantFiled: March 10, 2005Date of Patent: November 25, 2014Assignee: University of Virginia Patent FoundationInventors: Majd Alwan, Robin A. Felder, Steven W. Kell, Sarah G. Wood, Michael Cvetanovich, Beverly L. Turner, J. William Holman
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Patent number: 8551026Abstract: The gait monitor system and method provides various basic gait parameters including step count, cadence, and step duration, in addition to its ability to distinguish between normal, limping and shuffling gait modes, as well as determine falls. Moreover, this gait monitor may be provided with additional sensors, e.g. beam break at the beginning and end of a corridor to estimate average walking velocity (with the distance between the beams known or determined); this enables the calculation of additional gait characteristics such as average step length and average stride length. These parameters can additionally be used to detect various gait anomalies and other diagnostic information.Type: GrantFiled: December 23, 2010Date of Patent: October 8, 2013Assignee: University of Virginia Patent FoundationInventors: Majd Alwan, Robin A. Felder, Steven W. Kell, Siddharth Dalal
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Patent number: 8364232Abstract: A plug capable of providing information relating to a physical or chemical property of a body fluid, or the presence or amount of a molecular component therein in a living organism is disclosed. Specifically, one embodiment plug is capable of being inserted into a portion of a human eyelid in order to provide information relating to tear fluid is disclosed. This embodiment plug includes a body having a passage which allows for the natural flow of tear fluid therethrough. In addition, a sensing mechanism is provided which is capable of measuring, for example, glucose levels in the body of a patient through the analysis of the tear fluid. Such plug may further be designed so as to double as a punctal plug useful in preventing dry eye. Methods of utilizing and implanting such plugs are also disclosed.Type: GrantFiled: July 28, 2011Date of Patent: January 29, 2013Inventor: Robin A. Felder
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Publication number: 20120009559Abstract: The present invention relates generally to the field of cell culture, which is a laboratory process used primarily for the growth, propagation, and production of cells for analysis and the production and harvesting of cell products. The present invention comprises functionalized and/or engineered hydrogel microcarriers that exhibit any or all of the following properties: controllable buoyancy, ferro- or paramagnetism, molecular or fabricated reporting elements, and optical clarity. The microcarriers are used in a bioreactor that employs external forces to control said microcarrier kinetic energy and translational or positional orientation in order to facilitate cell growth and/or cellular analysis. The bioreactor can be part of an automated system that employs any or all of the following; a microcarrier manufacturing method, a monitoring method, a cell culture method, and an analytical method.Type: ApplicationFiled: July 15, 2011Publication date: January 12, 2012Applicant: Global Cell Solutions, LLCInventors: Robin A. FELDER, John J. Gildea
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Patent number: 8090426Abstract: A plug capable of providing information relating to a physical or chemical property of a body fluid, or the presence or amount of a molecular component therein in a living organism is disclosed. Specifically, one embodiment plug is capable of being inserted into a portion of a human eyelid in order to provide information relating to tear fluid is disclosed. This embodiment plug includes a body having a passage which allows for the natural flow of tear fluid therethrough. In addition, a sensing mechanism is provided which is capable of measuring, for example, glucose levels in the body of a patient through the analysis of the tear fluid. Such plug may further be designed so as to double as a punctual plug useful in preventing dry eye. Methods of utilizing and implanting such plugs are also disclosed.Type: GrantFiled: October 27, 2006Date of Patent: January 3, 2012Inventor: Robin A. Felder
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Publication number: 20110282171Abstract: A plug capable of providing information relating to a physical or chemical property of a body fluid, or the presence or amount of a molecular component therein in a living organism is disclosed. Specifically, one embodiment plug is capable of being inserted into a portion of a human eyelid in order to provide information relating to tear fluid is disclosed. This embodiment plug includes a body having a passage which allows for the natural flow of tear fluid therethrough. In addition, a sensing mechanism is provided which is capable of measuring, for example, glucose levels in the body of a patient through the analysis of the tear fluid. Such plug may further be designed so as to double as a punctal plug useful in preventing dry eye. Methods of utilizing and implanting such plugs are also disclosed.Type: ApplicationFiled: July 28, 2011Publication date: November 17, 2011Inventor: Robin A. Felder
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Publication number: 20110190667Abstract: The gait monitor system and method provides various basic gait parameters including step count, cadence, and step duration, in addition to its ability to distinguish between normal, limping and shuffling gait modes, as well as determine falls. Moreover, this gait monitor may be provided with additional sensors, e.g. beam break at the beginning and end of a corridor to estimate average walking velocity (with the distance between the beams known or determined); this enables the calculation of additional gait characteristics such as average step length and average stride length. These parameters can additionally be used to detect various gait anomalies and other diagnostic information.Type: ApplicationFiled: December 23, 2010Publication date: August 4, 2011Inventors: Majd Alwan, Robin A. Felder, Steven W. Kell, Siddharth Dalal
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Publication number: 20110087113Abstract: A system and method for detecting, monitoring and analyzing physiological characteristics. Signals from a subject are acquired from a suite of sensors, such as temperature, carbon dioxide, humidity, light, movement, electromagnetic and vibration sensors, in a passive, non-invasive manner. The signals are processed and physiological characteristics are isolated for analysis. The system and method are to analyze sleep patterns, as well as to prevent bed sores or detect conditions such as illness, restless leg syndrome, periodic leg movement, sleep walking, or sleep apnea. However, numerous other applications of the invention are also disclosed.Type: ApplicationFiled: August 30, 2010Publication date: April 14, 2011Applicant: WellAWARE Systems, Inc.Inventors: David C. Mack, Steve Kell, Majd Alwan, Robin Felder, Beverly Turner, Sarah Wood
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Patent number: 7857771Abstract: The gait monitor system and method provides various basic gait parameters including step count, cadence, and step duration, in addition to its ability to distinguish between normal, limping and shuffling gait modes, as well as determine falls. Moreover, this gait monitor may be provided with additional sensors, e.g. beam break at the beginning and end of a corridor to estimate average walking velocity (with the distance between the beams known or determined); this enables the calculation of additional gait characteristics such as average step length and average stride length. These parameters can additionally be used to detect various gait anomalies and other diagnostic information.Type: GrantFiled: March 26, 2004Date of Patent: December 28, 2010Assignee: University of Virginia Patent FoundationInventors: Majd Alwan, Robin A. Felder, Steven W. Kell, Siddharth Dalal
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Publication number: 20100313286Abstract: Disclosed are methods for identifying individuals predisposed to essential hypertension and related conditions such as salt sensitivity by detecting the presence of polymorphic or mutant forms of the GRK4 gene, or its expression product. Also disclosed are methods for identifying polymorphic or mutant GRK4s in individuals known to be suffering from such conditions, as well as methods and compositions for conducting drug discovery and therapeutic intervention.Type: ApplicationFiled: December 1, 2008Publication date: December 9, 2010Applicant: Georgetown UniversityInventors: Robin A. Felder, Pedro Jose
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Patent number: 7785257Abstract: A system and method for detecting, monitoring and analyzing physiological characteristics. Signals from a subject are acquired from a suite of sensors, such as temperature, carbon dioxide, humidity, light, movement, electromagnetic and vibration sensors, in a passive, non-invasive manner. The signals are processed and physiological characteristics are isolated for analysis. The system and method are to analyze sleep patterns, as well as to prevent bed sores or detect conditions such as illness, restless leg syndrome, periodic leg movement, sleep walking, or sleep apnea. However, numerous other applications of the invention are also disclosed.Type: GrantFiled: July 7, 2008Date of Patent: August 31, 2010Assignee: Home Guardian LLCInventors: David C. Mack, Steven W. Kell, Majd Alwan, Robin Felder, Beverly Turner, Sarah Wood
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Patent number: 7691068Abstract: System and method that can monitor pulse rate and passively produce a blood pressure measurement and automatically log the data for the user. Additionally, coupling to the Internet or Information Systems expands the options for the early detection of diseases, based on sudden detected changes and trend analyses, and the successful treatment of these patients while reducing the high costs associated with invasive procedures and in-hospital care.Type: GrantFiled: March 26, 2004Date of Patent: April 6, 2010Assignee: University of Virginia Patent FoundationInventors: Robin A. Felder, Majd Alwan, Steven W. Kell, David C. Mack
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Publication number: 20080275314Abstract: A system and method for detecting, monitoring and analyzing physiological characteristics. Signals from a subject are acquired from a suite of sensors, such as temperature, carbon dioxide, humidity, light, movement, electromagnetic and vibration sensors, in a passive, non-invasive manner. The signals are processed and physiological characteristics are isolated for analysis. The system and method are to analyze sleep patterns, as well as to prevent bed sores or detect conditions such as illness, restless leg syndrome, periodic leg movement, sleep walking, or sleep apnea. However, numerous other applications of the invention are also disclosed.Type: ApplicationFiled: July 7, 2008Publication date: November 6, 2008Applicant: Home Guardian LLCInventors: David C. Mack, Steve Kell, Majd Alwan, Robin Felder, Beverly Turner, Sarah Wood
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Patent number: 7396331Abstract: A system and method for detecting, monitoring and analyzing physiological characteristics. Signals from a subject are acquired from a suite of sensors, such as temperature, carbon dioxide, humidity, light, movement, electromagnetic and vibration sensors, in a passive, non-invasive manner. The signals are processed, and physiological characteristics are isolated for analysis. The system and method are to analyze sleep patterns, as well as to prevent bed sores or detect conditions such as illness, restless leg syndrome, periodic leg movement, sleep walking, or sleep apnea. However, numerous other applications of the invention are also disclosed.Type: GrantFiled: October 27, 2004Date of Patent: July 8, 2008Assignee: Home Guardian, LLCInventors: David C. Mack, Steve Kell, Majd Alwan, Robin Felder, Beverly Turner, Sarah Wood