Patents by Inventor Robin A. J. Smith

Robin A. J. Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for skin care
    Patent number: 10085966
    Abstract: Compositions and methods are for disclosed for treating a skin condition that results from reactive oxygen species production in skin of a subject, including applying a topical formulation that contains a lipophilic cation-mitochondrially targeted antioxidant compound and that delivers a therapeutically effective amount of the antioxidant compound to skin fibroblasts and keratinocytes.
    Type: Grant
    Filed: January 6, 2017
    Date of Patent: October 2, 2018
    Assignee: Antipodean Pharmaceuticals, Inc.
    Inventors: Michael Patrick Murphy, Robin A. J. Smith, Kenneth Martin Taylor
  • Mitoquinone derivatives used as mitochondrially targeted antioxidants
    Patent number: 7888335
    Abstract: This invention relates to pharmaceutically acceptable amphiphilic antioxidant compounds, compositions and dosage forms comprising said compounds, and methods and uses reliant on said compounds. The exemplified compounds are all mitoquinone derivatives, being methoxyphenyl alkyl triphenylphosphonium or methoxy dioxocyclohexadiene alkyl triphenylphosphonium derivatives. The compounds, compositions, dosage forms, uses and methods are useful in, for example, the treatment of diseases or conditions associated with oxidative stress.
    Type: Grant
    Filed: August 23, 2004
    Date of Patent: February 15, 2011
    Assignee: Antipodean Pharmaceuticals, Inc.
    Inventors: Kenneth Martin Taylor, Robin A. J. Smith
  • Mitochondrially targeted antioxidants
    Patent number: 7232809
    Abstract: The invention provides mitochondrially targeted antioxidant compounds. A compound of the invention comprises a lipophilic cation covalently coupled to an antioxidant moiety. In preferred embodiments, the lipophilic cation is the triphenyl phosphonium cation, and the compound is of the formula P(Ph3)+XR.Z? where X is a linking group, Z is an anion and R is an antioxidant moiety. Also provided are pharmaceutical compositions containing the mitochondrially targeted antioxidant compounds, and methods of therapy or prophylaxis of patients who would benefit from reduced oxidative stress, which comprise the step of administering the compounds of the invention.
    Type: Grant
    Filed: July 5, 2005
    Date of Patent: June 19, 2007
    Assignee: Antipodean Pharmaceuticals, Inc.
    Inventors: Michael P. Murphy, Robin A. J. Smith
  • Mitochondrially targeted antioxidants
    Patent number: 7109189
    Abstract: The invention provides mitochondrially targeted antioxidant compounds comprising a lipophilic cation moiety covalently coupled to a glutathione peroxidase mimetic. These compounds can be used to treat patients who would benefit from the reduction of oxidative stress.
    Type: Grant
    Filed: February 11, 2005
    Date of Patent: September 19, 2006
    Assignees: University of Otago, Medical Research Council
    Inventors: Michael P. Murphy, Robin A. J. Smith
  • Mitochondrially targeted antioxidants
    Patent number: 6984636
    Abstract: The invention provides mitochondrially targeted antioxidant compounds comprising a lipophilic cation moiety covalently coupled to an antioxidant moiety which is either a superoxide dismutase (SOD) mimetic or a glutathione peroxidase mimetic. These compounds can be used to treat patients who would benefit from the reduction of oxidative stress.
    Type: Grant
    Filed: August 12, 2002
    Date of Patent: January 10, 2006
    Assignees: Medical Research Council, University of Otago
    Inventors: Michael P. Murphy, Robin A. J. Smith
  • Mitochondrially targeted antioxidants
    Patent number: 6331532
    Abstract: The invention provides mitochondrially targeted antioxidant compounds. A compound of the invention comprises a lipophilic cation covalently coupled to an antioxidant moiety. In preferred embodiments, the lipophilic cation is the triphenyl phosphonium cation, and the compound is of the formula P(Ph3)+XR•Z− where X is a linking group, Z is an anion and R is an antioxidant moiety. Also provided are pharmaceutical compositions containing the mitochondrially targeted antioxidant compounds, and methods of therapy or prophylaxis of patients who would benefit from reduced oxidative stress, which comprise the step of administering the compounds of the invention.
    Type: Grant
    Filed: May 25, 2000
    Date of Patent: December 18, 2001
    Assignee: University of Otago
    Inventors: Michael P. Murphy, Robin A. J. Smith