Patents by Inventor Robin A. J. Smith
Robin A. J. Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20190008825Abstract: Compositions and methods are for disclosed for treating a skin condition that results from reactive oxygen species production in skin of a subject, including applying a topical formulation that contains a lipophilic cation-mitochondrially targeted antioxidant compound and that delivers a therapeutically effective amount of the antioxidant compound to skin fibroblasts and keratinocytes.Type: ApplicationFiled: September 11, 2018Publication date: January 10, 2019Inventors: Michael Patrick Murphy, Robin A.J. Smith, Kenneth Martin Taylor
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Patent number: 10085966Abstract: Compositions and methods are for disclosed for treating a skin condition that results from reactive oxygen species production in skin of a subject, including applying a topical formulation that contains a lipophilic cation-mitochondrially targeted antioxidant compound and that delivers a therapeutically effective amount of the antioxidant compound to skin fibroblasts and keratinocytes.Type: GrantFiled: January 6, 2017Date of Patent: October 2, 2018Assignee: Antipodean Pharmaceuticals, Inc.Inventors: Michael Patrick Murphy, Robin A. J. Smith, Kenneth Martin Taylor
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Publication number: 20170340603Abstract: Compositions and methods are for disclosed for treating a skin condition that results from reactive oxygen species production in skin of a subject, including applying a topical formulation that contains a lipophilic cation-mitochondrially targeted antioxidant compound and that delivers a therapeutically effective amount of the antioxidant compound to skin fibroblasts and keratinocytes.Type: ApplicationFiled: January 6, 2017Publication date: November 30, 2017Inventors: Michael Patrick Murphy, Robin A.J. Smith, Kenneth Martin Taylor
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Publication number: 20170246195Abstract: This invention relates to pharmaceutically acceptable amphiphilic antioxidant compounds, compositions and dosage forms comprising said compounds and methods and uses reliant on said compounds. The exemplified compounds are all mitoquinone derivatives, being methoxyphenyl alkyl triphenylphosphonium or methoxy dioxocyclohexadiene alkyl triphenylphosphonium derivatives. The compounds, compositions, dosage forms, uses and methods are useful in, for example, the treatment of diseases or conditions associated with oxidative stress.Type: ApplicationFiled: October 14, 2016Publication date: August 31, 2017Inventors: Kenneth Martin Taylor, Robin A.J. Smith
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Publication number: 20110288055Abstract: This invention relates to pharmaceutically acceptable amphiphilic antioxidant compounds, compositions and dosage forms comprising said compounds, and methods and uses reliant on said compounds. The exemplified compounds are all mitoquinone derivatives, being methoxyphenyl alkyl triphenylphosphonium or methoxy dioxocyclohexadiene alkyl triphenylphosphonium derivatives. The compounds, compositions, dosage forms, uses and methods are useful in, for example, the treatment of diseases or conditions associated with oxidative stress.Type: ApplicationFiled: January 5, 2011Publication date: November 24, 2011Inventors: Kenneth Martin Taylor, Robin A.J. Smith
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Patent number: 7888335Abstract: This invention relates to pharmaceutically acceptable amphiphilic antioxidant compounds, compositions and dosage forms comprising said compounds, and methods and uses reliant on said compounds. The exemplified compounds are all mitoquinone derivatives, being methoxyphenyl alkyl triphenylphosphonium or methoxy dioxocyclohexadiene alkyl triphenylphosphonium derivatives. The compounds, compositions, dosage forms, uses and methods are useful in, for example, the treatment of diseases or conditions associated with oxidative stress.Type: GrantFiled: August 23, 2004Date of Patent: February 15, 2011Assignee: Antipodean Pharmaceuticals, Inc.Inventors: Kenneth Martin Taylor, Robin A. J. Smith
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Publication number: 20090258841Abstract: Compositions and methods are for disclosed for treating a skin condition that results from reactive oxygen species production in skin of a subject, including applying a topical formulation that contains a lipophilic cation-mitochondrially targeted antioxidant compound and that delivers a therapeutically effective amount of the antioxidant compound to skin fibroblasts and keratinocytes.Type: ApplicationFiled: March 24, 2009Publication date: October 15, 2009Inventors: Michael Patrick Murphy, Robin A.J. Smith, Kenneth Martin Taylor
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Publication number: 20080275005Abstract: The invention provides mitochondrially targeted antioxidant compounds. A compound of the invention comprises a lipophilic cation covalently coupled to an antioxidant moiety. In preferred embodiments, the lipophilic cation is the triphenyl phosphonium cation, and the compound is of the formula P(Ph3)+XR.Z- where X is a linking group, Z is an anion and R is an antioxidant moiety. Also provided are pharmaceutical compositions containing the mitochondrially targeted antioxidant compounds, and methods of therapy or prophylaxis of patients who would benefit from reduced oxidative stress, which comprise the step of administering the compounds of the invention.Type: ApplicationFiled: April 24, 2008Publication date: November 6, 2008Inventors: Michael P. Murphy, Robin A.J. Smith
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Publication number: 20080161267Abstract: This invention relates to pharmaceutically acceptable amphiphilic antioxidant compounds, compositions and dosage forms comprising said compounds, and methods and uses reliant on said compounds. The exemplified compounds are all mitoquinone derivatives, being methoxyphenyl alkyl triphenylphosphonium or methoxy dioxocyclohexadiene alkyl triphenylphosphonium derivatives. The compounds, compositions, dosage forms, uses and methods are useful in, for example, the treatment of diseases or conditions associated with oxidative stress.Type: ApplicationFiled: August 23, 2004Publication date: July 3, 2008Applicant: Antipodean Pharmaceuticals, Inc.Inventors: Kenneth Martin Taylor, Robin A.J. Smith
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Publication number: 20080108545Abstract: The invention provides a triphenylphosphonium peptide nucleic acid conjugate. The conjugate comprises a peptide nucleic acid linked via a disulfide bond, to a triphenylphosphonium group. Conjugates of the invention can be used to deliver PNA oligomers across the plasma membrane into cells.Type: ApplicationFiled: October 15, 2004Publication date: May 8, 2008Applicant: UNIVERSITY OF OTAGOInventors: Roger Michael Eccles, Aleksandra Filipovska, Robin A.J. Smith, Michael Patrick Murphy
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Patent number: 7232809Abstract: The invention provides mitochondrially targeted antioxidant compounds. A compound of the invention comprises a lipophilic cation covalently coupled to an antioxidant moiety. In preferred embodiments, the lipophilic cation is the triphenyl phosphonium cation, and the compound is of the formula P(Ph3)+XR.Z? where X is a linking group, Z is an anion and R is an antioxidant moiety. Also provided are pharmaceutical compositions containing the mitochondrially targeted antioxidant compounds, and methods of therapy or prophylaxis of patients who would benefit from reduced oxidative stress, which comprise the step of administering the compounds of the invention.Type: GrantFiled: July 5, 2005Date of Patent: June 19, 2007Assignee: Antipodean Pharmaceuticals, Inc.Inventors: Michael P. Murphy, Robin A. J. Smith
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Patent number: 7109189Abstract: The invention provides mitochondrially targeted antioxidant compounds comprising a lipophilic cation moiety covalently coupled to a glutathione peroxidase mimetic. These compounds can be used to treat patients who would benefit from the reduction of oxidative stress.Type: GrantFiled: February 11, 2005Date of Patent: September 19, 2006Assignees: University of Otago, Medical Research CouncilInventors: Michael P. Murphy, Robin A. J. Smith
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Patent number: 6984636Abstract: The invention provides mitochondrially targeted antioxidant compounds comprising a lipophilic cation moiety covalently coupled to an antioxidant moiety which is either a superoxide dismutase (SOD) mimetic or a glutathione peroxidase mimetic. These compounds can be used to treat patients who would benefit from the reduction of oxidative stress.Type: GrantFiled: August 12, 2002Date of Patent: January 10, 2006Assignees: Medical Research Council, University of OtagoInventors: Michael P. Murphy, Robin A. J. Smith
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Publication number: 20040106579Abstract: The invention provides mitochondrially targeted antioxidant compounds. A compound of the invention comprises a lipophilic cation covalently coupled to an antioxidant moiety. In preferred embodiments, the lipophilic cation is the triphenyl phosphonium cation, and the compound is of the formula P(Ph3)+XR.Z- where X is a linking group, Z is an anion and R is an antioxidant moiety. Also provided are pharmaceutical compositions containing the mitochondrially targeted antioxidant compounds, and methods of therapy or prophylaxis of patients who would benefit from reduced oxidative stress, which comprise the step of administering the compounds of the invention.Type: ApplicationFiled: November 28, 2003Publication date: June 3, 2004Applicant: University of OtagoInventors: Michael P. Murphy, Robin A.J. Smith
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Publication number: 20040029851Abstract: The invention provides mitochondrially targeted antioxidant compounds comprising a lipophilic cation moiety covalently coupled to an antioxidant moiety which is either a superoxide dismutase (SOD) mimetic or a glutathione peroxidase mimetic. These compounds can be used to treat patients who would benefit from the reduction of oxidative stress.Type: ApplicationFiled: August 12, 2002Publication date: February 12, 2004Applicants: Medical Research Council, University of OtagoInventors: Michael P. Murphy, Robin A.J. Smith
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Publication number: 20030069208Abstract: The invention provides mitochondrially targeted antioxidant compounds. A compound of the invention comprises a lipophilic cation covalently coupled to an antioxidant moiety. In preferred embodiments, the lipophilic cation is the triphenyl phosphonium cation, and the compound is of the formula P(Ph3)+XR·Z− where X is a linking group, Z is an anion and R is an antioxidant moiety. Also provided are pharmaceutical compositions containing the mitochondrially targeted antioxidant compounds, and methods of therapy or prophylaxis of patients who would benefit from reduced oxidative stress, which comprise the step of administering the compounds of the invention.Type: ApplicationFiled: October 18, 2002Publication date: April 10, 2003Applicant: University of OtagoInventors: Michael P. Murphy, Robin A.J. Smith
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Publication number: 20020052342Abstract: The invention provides mitochondrially targeted antioxidant compounds. A compound of the invention comprises a lipophilic cation covalently coupled to an antioxidant moiety. In preferred embodiments, the lipophilic cation is the triphenyl phosphonium cation, and the compound is of the formula P(Ph3)+XR.Z− where X is a linking group, Z is an anion and R is an antioxidant moiety. Also provided are pharmaceutical compositions containing the mitochondrially targeted antioxidant compounds, and methods of therapy or prophylaxis of patients who would benefit from reduced oxidative stress, which comprise the step of administering the compounds of the invention.Type: ApplicationFiled: October 3, 2001Publication date: May 2, 2002Applicant: University of OtagoInventors: Michael P. Murphy, Robin A.J. Smith
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Patent number: 6331532Abstract: The invention provides mitochondrially targeted antioxidant compounds. A compound of the invention comprises a lipophilic cation covalently coupled to an antioxidant moiety. In preferred embodiments, the lipophilic cation is the triphenyl phosphonium cation, and the compound is of the formula P(Ph3)+XR•Z− where X is a linking group, Z is an anion and R is an antioxidant moiety. Also provided are pharmaceutical compositions containing the mitochondrially targeted antioxidant compounds, and methods of therapy or prophylaxis of patients who would benefit from reduced oxidative stress, which comprise the step of administering the compounds of the invention.Type: GrantFiled: May 25, 2000Date of Patent: December 18, 2001Assignee: University of OtagoInventors: Michael P. Murphy, Robin A. J. Smith