Patents by Inventor Robin EDWARDS

Robin EDWARDS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11807686
    Abstract: The invention provides a method of treating a tumor in a human patient comprising (i) identifying a patient as having a LAG-3 positive tumor and (ii) administering to the patient a PD-1 pathway inhibitor, a combination of a PD1 pathway inhibitor and an immune checkpoint inhibitor, a combination of a LAG-3 inhibitor and a PD-1 pathway inhibitor, or an anti-CTLA4 antibody. In some embodiments, the method further comprises identifying the patient as having a LAG-3 positive PD-L1 positive tumor. In some embodiments, the LAG-3 inhibitor is an anti-LAG-3 antibody and the PD-1 pathway inhibitor is an anti-PD-1 antibody. The methods of the invention can improve response rates to treatment with a PD-1 pathway inhibitor, a combination of a PD1 pathway inhibitor and an immune checkpoint inhibitor, or a combination of a LAG-3 inhibitor and a PD-1 pathway inhibitor.
    Type: Grant
    Filed: May 30, 2018
    Date of Patent: November 7, 2023
    Assignee: Bristol-Myers Squibb Company
    Inventors: James Novotny, Jr., Nils Lonberg, Cyrus Hedvat, Raphael Clynes, Darren Locke, John P. Cogswell, Jeffrey Jackson, Christopher Harbison, Robin Edwards
  • Publication number: 20230306762
    Abstract: Described herein are methods and computer systems for classification of CD8 T-cell topology using artificial intelligence and machine learning. A plurality of histology images of tissue samples in a plurality of patients are received by a computer system. An image analysis of the plurality of histology images is performed to obtain a CD8+ T-cell abundance in the tumor parenchyma and stroma in each of the plurality of histology images. A machine learning algorithm is then trained using results of the image analysis and the CD8+ T-cell abundance in the tumor parenchyma and stroma. Based on the training, a machine learning feature space comprising a plurality of classifications is generated, and boundaries between the plurality of classifications in the machine learning feature space are identified.
    Type: Application
    Filed: August 31, 2021
    Publication date: September 28, 2023
    Applicant: Bristol-Myers Squibb Company
    Inventors: George C. LEE, Robin EDWARDS, Scott ELY, Daniel N. COHEN, John B. WOJCIK, Vipul A. BAXI, Dimple PANDYA, Jimena TRILLO-TINOCO, Benjamin J. CHEN, Andrew FISHER, Falon GRAY
  • Publication number: 20230303700
    Abstract: The present disclosure provides methods of identifying a subject suitable for an anti-PD-?PD-L1 antagonist therapy comprising measuring assay CD8 localization and PD-L1 expression in a tumor sample obtained from the subject. In some aspects, method further comprises administering (i) an anti-PD-?PD-L1 antagonist therapy or (ii) an anti-PD-?PD-L1 antagonist and anti-CT-LA-4 antagonist combination therapy to a subject identified as having a tumor exhibiting an excluded CD8 localization phenotype, wherein the tumor is PD-L1 negative.
    Type: Application
    Filed: August 31, 2021
    Publication date: September 28, 2023
    Applicant: Bristol-Myers Squibb Company
    Inventors: George C. LEE, Robin EDWARDS, Scott ELY, Daniel N. COHEN, John B. WOJCIK, Vipul A. BAXI, Dimple PANDYA, Jimena TRILLO-TINOCO, Benjamin J. CHEN, Andrew FISHER, Falon GRAY
  • Publication number: 20230279114
    Abstract: This disclosure provides a method for treating a subject afflicted with tumor, which method comprises administering to the subject an antibody or an antigen-binding portion thereof that specifically binds to a Programmed Death-1 (PD-1) receptor and inhibits PD-1 activity. In some embodiments, the tumor is derived from a non-small cell lung cancer (NSCLC). In some embodiments, the tumor expresses Programmed Death Ligand 1. In some embodiments, the subject carries a wild-type STK11 gene.
    Type: Application
    Filed: January 30, 2023
    Publication date: September 7, 2023
    Applicant: Bristol-Myers Squibb Company
    Inventors: Robin EDWARDS, William J. GEESE, Danielle M. GREENAWALT
  • Patent number: 11566073
    Abstract: This disclosure provides a method for treating a subject afflicted with tumor, which method comprises administering to the subject an antibody or an antigen-binding portion thereof that specifically binds to a Programmed Death-1 (PD-1) receptor and inhibits PD-1 activity. In some embodiments, the tumor is derived from a non-small cell lung cancer (NSCLC). In some embodiments, the tumor expresses Programmed Death Ligand 1. In some embodiments, the subject carries a wild-type STK11 gene.
    Type: Grant
    Filed: June 1, 2018
    Date of Patent: January 31, 2023
    Assignee: Bristol-Myers Squibb Company
    Inventors: Robin Edwards, William J. Geese, Danielle M. Greenawalt
  • Publication number: 20220348653
    Abstract: The disclosure provides LAG-3 antagonists and methods comprising the same for treating a cancer in a subject based on a LAG-3 density score and/or a LAG-3 proportion score in a tumor sample from the subject. The disclosure also provides methods of identifying a subject responsive to a LAG-3 antagonist therapy.
    Type: Application
    Filed: September 22, 2020
    Publication date: November 3, 2022
    Applicant: Bristol-Myers Squibb Company
    Inventors: Cyrus HEDVAT, Robin EDWARDS, George C. LEE, Vipual Atulkumar BAXI
  • Publication number: 20220315657
    Abstract: This disclosure provides a method for treating a subject afflicted with tumor, which method comprises administering to the subject an antibody or an antigen-binding portion thereof that specifically binds to a Programmed Death-1 (PD-1) receptor and inhibits PD-1 activity. In some embodiments, the tumor is derived from a non-small cell lung cancer (NSCLC). In some embodiments, the tumor expresses Programmed Death Ligand 1 (PD-L1), Serine/Threonine Kinase 11 (STK11), or both PD-L1 and STK11.
    Type: Application
    Filed: March 21, 2022
    Publication date: October 6, 2022
    Applicant: Bristol-Myers Squibb Company
    Inventors: Robin EDWARDS, Han CHANG, Michele CLEARY, Peter M. SZABO, Joseph Daniel SZUSTAKOWSKI, Patrik VITAZKA
  • Publication number: 20210261666
    Abstract: The invention provides a method of treating a tumor in a human patient comprising (i) identifying a patient as having a LAG-3 positive tumor and (ii) administering to the patient a PD-1 pathway inhibitor, a combination of a PD1 pathway inhibitor and an immune checkpoint inhibitor, a combination of a LAG-3 inhibitor and a PD-1 pathway inhibitor, or an anti-CTLA4 antibody. In some embodiments, the method further comprises identifying the patient as having a LAG-3 positive PD-Ll positive tumor. In some embodiments, the LAG-3 inhibitor is an anti-LAG-3 antibody and the PD-1 pathway inhibitor is an anti-PD-1 antibody. The methods of the invention can improve response rates to treatment with a PD-1 pathway inhibitor, a combination of a PD1 pathway inhibitor and an immune checkpoint inhibitor, or a combination of a LAG-3 inhibitor and a PD-1 pathway inhibitor.
    Type: Application
    Filed: May 30, 2018
    Publication date: August 26, 2021
    Applicant: Bristol-Myers Squibb Company
    Inventors: James NOVOTNY, JR., Nils LONBERG, Cyrus HEDVAT, Raphael CLYNES, Darren LOCKE, John P. COGSWELL, Jeffrey JACKSON, Christopher HARBISON, Robin EDWARDS
  • Patent number: 10989178
    Abstract: A method of electricity production using water thermal energy includes compressing an enclosed working fluid at a first vertical position relative to a surface of a body of water to cause the fluid to move to a second vertical position relative to the surface and subsequently move to the first position in a closed loop, an external environment at the second position having a greater temperature than an external environment at the first position such that the fluid transitions between a liquid phase at the first position and a vapor phase at the second position, the compressing using power from a battery, and expanding the fluid at the second position to generate electricity to charge the battery. The first and second positions may be two depths of the body of water or a height of an atmosphere above the body of water and a depth of the body of water.
    Type: Grant
    Filed: September 6, 2019
    Date of Patent: April 27, 2021
    Assignee: Seatrec, Inc.
    Inventors: Jack A. Jones, Yi Chao, David M. Fratantoni, Michael Martin Zedelmair, Robin Edward Willis, Robert Scott Leland
  • Publication number: 20200325226
    Abstract: This disclosure provides a method for treating a subject afflicted with tumor, which method comprises administering to the subject an antibody or an antigen-binding portion thereof that specifically binds to a Programmed Death-1 (PD-1) receptor and inhibits PD-1 activity. In some embodiments, the tumor is derived from a non-small cell lung cancer (NSCLC). In some embodiments, the tumor expresses Programmed Death Ligand 1 (PD-L1), Serine/Threonine Kinase 11 (STK11), or both PD-L1 and STK11.
    Type: Application
    Filed: June 2, 2017
    Publication date: October 15, 2020
    Applicant: Bristol-Myers Squibb Company
    Inventors: Robin EDWARDS, Han CHANG, Michele CLEARY, Peter M. SZABO, Joseph D. SZUSTAKOWSKI, Patrik VITAZKA
  • Publication number: 20200109204
    Abstract: This disclosure provides a method for treating a subject afflicted with tumor, which method comprises administering to the subject an antibody or an antigen-binding portion thereof that specifically binds to a Programmed Death-1 (PD-1) receptor and inhibits PD-1 activity. In some embodiments, the tumor is derived from a non-small cell lung cancer (NSCLC). In some embodiments, the tumor expresses Programmed Death Ligand 1. In some embodiments, the subject carries a wild-type STK11 gene.
    Type: Application
    Filed: June 1, 2018
    Publication date: April 9, 2020
    Applicant: Bristol-Myers Squibb Company
    Inventors: Robin EDWARDS, William J. GEESE, Danielle M. GREENAWALT
  • Publication number: 20200003188
    Abstract: A method of electricity production using water thermal energy includes compressing an enclosed working fluid at a first vertical position relative to a surface of a body of water to cause the fluid to move to a second vertical position relative to the surface and subsequently move to the first position in a closed loop, an external environment at the second position having a greater temperature than an external environment at the first position such that the fluid transitions between a liquid phase at the first position and a vapor phase at the second position, the compressing using power from a battery, and expanding the fluid at the second position to generate electricity to charge the battery. The first and second positions may be two depths of the body of water or a height of an atmosphere above the body of water and a depth of the body of water.
    Type: Application
    Filed: September 6, 2019
    Publication date: January 2, 2020
    Inventors: Jack A. Jones, Yi Chao, David M. Fratantoni, Michael Martin Zedelmair, Robin Edward Willis, Robert Scott Leland
  • Patent number: 10443581
    Abstract: A method of electricity production using water thermal energy includes compressing an enclosed working fluid at a first vertical position relative to a surface of a body of water to cause the fluid to move to a second vertical position relative to the surface and subsequently move to the first position in a closed loop, an external environment at the second position having a greater temperature than an external environment at the first position such that the fluid transitions between a liquid phase at the first position and a vapor phase at the second position, the compressing using power from a battery, and expanding the fluid at the second position to generate electricity to charge the battery. The first and second positions may be two depths of the body of water or a height of an atmosphere above the body of water and a depth of the body of water.
    Type: Grant
    Filed: October 31, 2017
    Date of Patent: October 15, 2019
    Assignee: Seatrec, Inc.
    Inventors: Jack A. Jones, Yi Chao, David M. Fratantoni, Michael Martin Zedelmair, Robin Edward Willis, Robert Scott Leland
  • Publication number: 20180119680
    Abstract: A method of electricity production using water thermal energy includes compressing an enclosed working fluid at a first vertical position relative to a surface of a body of water to cause the fluid to move to a second vertical position relative to the surface and subsequently move to the first position in a closed loop, an external environment at the second position having a greater temperature than an external environment at the first position such that the fluid transitions between a liquid phase at the first position and a vapor phase at the second position, the compressing using power from a battery, and expanding the fluid at the second position to generate electricity to charge the battery. The first and second positions may be two depths of the body of water or a height of an atmosphere above the body of water and a depth of the body of water.
    Type: Application
    Filed: October 31, 2017
    Publication date: May 3, 2018
    Inventors: Jack A. Jones, Yi Chao, David M. Fratantoni, Michael Martin Zedelmair, Robin Edward Willis, Robert Scott Leland
  • Publication number: 20130013727
    Abstract: A system and method are disclosed for providing a mobile persona environment hosted by a network accessible server that can be activated by network connected client device. The client device points the portion of its file system used by the operating system to configure the desktop environment to a persona container hosted by the server. The persona container includes user data, applications and operating system settings or policies that are used to configure the operating system of the client device to provide the mobile persona environment. The client device obtains user profile information and connection information from a persona reference object stored on the client device. Applications are executed locally on the client device while the data remains secure in the network accessible server.
    Type: Application
    Filed: July 5, 2011
    Publication date: January 10, 2013
    Inventor: Robin Edward Walker
  • Patent number: 8114775
    Abstract: A chemical mechanical polishing composition contains 1) water, 2) optionally an abrasive material, 3) an oxidizer, preferably a per-type oxidizer, 4) a small amount of soluble metal-ion oxidizer/polishing accelerator, a metal-ion polishing accelerator bound to particles such as to abrasive particles, or both; and 5) at least one of the group selected from a) a small amount of a chelator, b) a small amount of a dihydroxy enolic compound, and c) a small amount of an organic accelerator. Ascorbic acid in an amount less than 800 ppm, preferably between about 100 ppm and 500 ppm, is the preferred dihydroxy enolic compound. The polishing compositions and processes are useful for substantially all metals and metallic compounds found in integrated circuits, but is particularly useful for tungsten.
    Type: Grant
    Filed: January 13, 2009
    Date of Patent: February 14, 2012
    Assignee: DuPont Air Products Nanomaterials, LLC
    Inventors: Junaid Ahmed Siddiqui, Daniel Hernandez Castillo, Steven Masami Aragaki, Robin Edward Richards
  • Patent number: 7691287
    Abstract: A method of polishing a substrate with a polishing composition comprising an oxidizing agent and abrasive particles having a surface, said surface of the abrasive particles being at least partially modified with 1) at least one stabilizer compound comprising aluminum, boron, tungsten, or both, said stabilizer compound being bound via a covalent bond to said abrasive particles, and 2) an organic chelating compound, said chelating compound being bound via a covalent bond to said stabilizer compound. The organic chelating compounds include one or more of 1) a nitrogen-containing moiety and between one and five other polar groups; 2) a sulfur-containing moiety and between one and five other polar groups; and 3) between two and five polar groups selected from carboxylic acid groups or salts thereof and hydroxyl groups.
    Type: Grant
    Filed: January 31, 2007
    Date of Patent: April 6, 2010
    Assignee: DuPont Air Products NanoMaterials LLC
    Inventors: Junaid Ahmed Siddiqui, Timothy Frederick Compton, Robin Edward Richards
  • Publication number: 20090308836
    Abstract: A chemical mechanical polishing composition contains 1) water, 2) optionally an abrasive material, 3) an oxidizer, preferably a per-type oxidizer, 4) a small amount of soluble metal-ion oxidizer/polishing accelerator, a metal-ion polishing accelerator bound to particles such as to abrasive particles, or both; and 5) at least one of the group selected from a) a small amount of a chelator, b) a small amount of a dihydroxy enolic compound, and c) a small amount of an organic accelerator. Ascorbic acid in an amount less than 800 ppm, preferably between about 100 ppm and 500 ppm, is the preferred dihydroxy enolic compound. The polishing compositions and processes are useful for substantially all metals and metallic compounds found in integrated circuits, but is particularly useful for tungsten.
    Type: Application
    Filed: January 13, 2009
    Publication date: December 17, 2009
    Inventors: Junaid Ahmed Siddiqui, Daniel Hernandez Castillo, Steven Masaml Aragaki, Robin Edward Richards
  • Patent number: 7571517
    Abstract: The tool handle of the invention includes a shank connected via a ratcheting mechanism to a male square drive. A pair of handle wings are pivotally connected to the shank at a transverse pivot hinge such that the handle wings can be changed between a screwdriver-type configuration, an L-shape configuration, a T-shape configuration or other intermediate configurations. When the handle wings are in the fully open position, the handle wings bear against the shank to create a mechanism for transferring power between the handle wings and the tool shank without the need for a separate lock. A quick change adapter having a female drive can be connected to the male square drive such that the tool handle can be used with a wide variety of tools including taps and extractors, sockets, screwdriver bits and the like.
    Type: Grant
    Filed: June 29, 2005
    Date of Patent: August 11, 2009
    Assignee: Irwin Industrial Tool Company
    Inventors: Robin Edward Smith, Brandon C. Hoover
  • Patent number: 7476620
    Abstract: A chemical mechanical polishing composition contains 1) water, 2) optionally an abrasive material, 3) an oxidizer, preferably a per-type oxidizer, 4) a small amount of soluble metal-ion oxidizer/polishing accelerator, a metal-ion polishing accelerator bound to particles such as to abrasive particles, or both; and 5) at least one of the group selected from a) a small amount of a chelator, b) a small amount of a dihydroxy enolic compound, and c) a small amount of an organic accelerator. Ascorbic acid in an amount less than 800 ppm, preferably between about 100 ppm and 500 ppm, is the preferred dihydroxy enolic compound. The polishing compositions and processes are useful for substantially all metals and metallic compounds found in integrated circuits, but is particularly useful for tungsten.
    Type: Grant
    Filed: March 24, 2006
    Date of Patent: January 13, 2009
    Assignee: DuPont Air Products NanoMaterials LLC
    Inventors: Junaid Ahmed Siddiqui, Daniel Hernandez Castillo, Steven Masami Aragaki, Robin Edward Richards