Patents by Inventor Robin Gerald Shepherd

Robin Gerald Shepherd has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6831078
    Abstract: A compound of formula (1) wherein R1 is aryl; and R2 is hydrogen or alkyl; pharmaceutically acceptable addition compounds thereof; and their use in therapy, particularly for the treatment and prophylaxis of CNS disorders such as anxiety and epilepsy.
    Type: Grant
    Filed: February 12, 2001
    Date of Patent: December 14, 2004
    Assignee: Vernalis Research Limited
    Inventors: David Reginald Adams, Jon Bentley, Corinna Dagmar Bodkin, Ian Anthony Cliffe, James Edward Paul Davidson, Howard Langham Mansell, Nathaniel Julius Monck, Robin Gerald Shepherd, by Joy Miriam Shepherd
  • Patent number: 6403574
    Abstract: A compound of formula (1), wherein: R1 is aryl; R2 is H, alkyl or aryl; and R3 is hydrogen or alkyl; pharmaceutically acceptable addition compounds thereof; and the use of the compounds in therapy, particularly for the treatment and prophylaxis of CNS disorders such as anxiety and epilepsy.
    Type: Grant
    Filed: September 17, 2001
    Date of Patent: June 11, 2002
    Assignee: Vernalis Research Limited
    Inventors: David Reginald Adams, Corinna Dagmar Bodkin, Ian Anthony Cliffe, Howard Langham Mansell, Nathaniel Julius Monck, Robin Gerald Shepherd
  • Patent number: 6395902
    Abstract: Compounds having the formula R5O—A—NR4—R2  (V) where R2 is a heteroaryl group linked to the remainder of the molecule via a carbon atom adjacent a nitrogen atom and R4 and R5 are both hydrogen atoms or together represent —SO— or —SO2— and A is C2-C4 alkylene optionally substituted by one or more lower alkyl groups are novel intermediates in the preparation of pharmaceutically useful piperazine derivatives as end compounds. The compounds having formula V where R4 and R5 are hydrogen may be prepared by a rearrangement of a compound having the formula (VI).
    Type: Grant
    Filed: July 12, 2000
    Date of Patent: May 28, 2002
    Assignee: John Wyeth & Brother Limited
    Inventors: Christopher Ian Brightwell, Robin Gerald Shepherd
  • Patent number: 6175012
    Abstract: Compounds having the formula R5O—A—NR4—R2  (V) where R2 is a heteroaryl group linked to the remainder of the molecule via a carbon atom adjacent a nitrogen atom and R4 and R5 are both hydrogen atoms or together represent —SO— or —SO2— and A is C2-C4 alkylene optionally substituted by one or more lower alkyl groups are novel intermediates in the preparation of pharmaceutically useful piperazine derivatives as end compounds. The compounds having formula V where R4 and R5 are hydrogen may be prepared by a rearrangement of a compound having the formula (VI).
    Type: Grant
    Filed: January 22, 1998
    Date of Patent: January 16, 2001
    Assignee: John Wyeth & Brother Ltd.
    Inventors: Christopher Ian Brightwell, Robin Gerald Shepherd
  • Patent number: 6133449
    Abstract: Compounds having the formulaR.sup.5 O--A--NR.sup.4 --R.sup.2 (V)where R.sup.2 is a heteroaryl group linked to the remainder of the molecule via a carbon atom adjacent a nitrogen atom and R.sup.4 and R.sup.5 are both hydrogen atoms or together represent --SO-- or --SO.sub.2 -- and A is C.sub.2 -C.sub.4 alkylene optionally substituted by one or more lower alkyl groups are novel intermediates in the preparation of pharmaceutically useful piperazine derivatives as end compounds. The compounds having formula V where R.sup.4 and R.sup.5 are hydrogen may be prepared by a rearrangement of a compound having the formula (VI).R.sup.2 O--A--NH.sub.
    Type: Grant
    Filed: January 22, 1998
    Date of Patent: October 17, 2000
    Assignee: John Wyeth & Brother Ltd.
    Inventors: Christopher Ian Brightwell, Robin Gerald Shepherd
  • Patent number: 4085108
    Abstract: The invention relates to novel silicon derivatives of tetrahydroquinolines, which are intermediates in a process for preparing 5,6,7,8-tetrahydroquinoline-8-carboxamides and thiocarboxamides.
    Type: Grant
    Filed: September 8, 1976
    Date of Patent: April 18, 1978
    Assignee: John Wyeth & Brother Ltd.
    Inventors: Adrian Charles Ward Curran, Robin Gerald Shepherd
  • Patent number: 4046895
    Abstract: The invention provides a compound of formula I ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and represent hydrogen or alkyl of 1-6 carbon atoms, R.sup.3 represents hydrogen, alkyl of 1-6 carbon atoms, or phenyl, X is Na, K, Li, or CSNHR.sup.4 wherein R.sup.4 is hydrogen or alkyl of 1-6 carbon atoms and n is 3, 4 or 5 or a pharmaceutically acceptacle acid addition salt of a compound where X is CSNHR.sup.4.The compounds of formula I wherein X is CSNHR.sup.4 are anti-ulcer agents. Those in which X is Na, K or Li are intermediates.
    Type: Grant
    Filed: January 23, 1976
    Date of Patent: September 6, 1977
    Assignee: John Wyeth & Brother Limited
    Inventors: Adrian Charles Ward Curran, Robin Gerald Shepherd
  • Patent number: 4000142
    Abstract: The invention relates to a process for preparing pyridine compounds which have a fused cycloalkane ring containing an amide, thioamide or nitrile group. The process involves treating a metal derivative of the pyridine compound with a silyl isocyanate or isothiocyanate and then subjecting the product to hydrolysis or alcoholysis.
    Type: Grant
    Filed: November 25, 1974
    Date of Patent: December 28, 1976
    Assignee: John Wyeth & Brother Limited
    Inventors: Adrian Charles Ward Curran, Robin Gerald Shepherd