Abstract: The present invention relates to medical devices and particularly to a medication delivery device for self-injection of a medication, or for healthcare professionals to administer a medication. In one embodiment, a medication delivery device utilizes a source of gas pressure to deploy a needle, deliver a desired amount of medication through the needle, and retract the needle for disposal. Fluid flow paths from the source of gas pressure communicate the gas pressure to the needle and to the medication in order to accomplish these steps. In one embodiment, a valve is positioned to open and close the flow of the pressurized gas to the needle and the flow of the medication to the needle, so that the valve can be operated to deploy the needle and deliver the medication through the needle when the user is ready for the injection. The valve can also be operated to retract the needle when the dose is complete.

Abstract: The present invention relates to medical devices and particularly to a medication delivery device for self-injection of a medication, or for healthcare professionals to administer a medication. In one embodiment, a medication delivery device utilizes a source of gas pressure to deploy a needle, deliver a desired amount of medication through the needle, and retract the needle for disposal. Fluid flow paths from the source of gas pressure communicate the gas pressure to the needle and to the medication in order to accomplish these steps. In one embodiment, a valve is positioned to open and close the flow of the pressurized gas to the needle and the flow of the medication to the needle, so that the valve can be operated to deploy the needle and deliver the medication through the needle when the user is ready for the injection. The valve can also be operated to retract the needle when the dose is complete.

Abstract: A method and device for intradermal delivery of a reconstituted medicament. The device includes a chamber, which is in fluid communication with a microdevice, e.g. microabrader or one or more microneedles. A cartridge containing the medicament may be located within said chamber. At least one burstable membrane retains a medicament within the housing. The method involves the steps of positioning the device at a delivery site on the skin of a patient and intradermally administering the medicament by dispensing a diluent from a diluent source an through inlet port to rupture the membranes, reconstitute the medicament and deliver the reconstituted medicament through the microdevice to the dermal region of the skin.

Abstract: A method and device for intradermal delivery of a reconstituted medicament. The device includes a chamber, which is in fluid communication with a microdevice, e.g. microabrader or one or more microneedles. A cartridge containing the medicament may be located within said chamber. At least one burstable membrane retains a medicament within the housing. The method involves the steps of positioning the device at a delivery site on the skin of a patient and intradermally administering the medicament by dispensing a diluent from a diluent source an through inlet port to rupture the membranes, reconstitute the medicament and deliver the reconstituted medicament through the microdevice to the dermal region of the skin.

Abstract: The present invention relates to medical devices and particularly to a medication delivery device for self-injection of a medication, or for healthcare professionals to administer a medication. In one embodiment, a medication delivery device utilizes a source of gas pressure to deploy a needle, deliver a desired amount of medication through the needle, and retract the needle for disposal. Fluid flow paths from the source of gas pressure communicate the gas pressure to the needle and to the medication in order to accomplish these steps. In one embodiment, a valve is positioned to open and close the flow of the pressurized gas to the needle and the flow of the medication to the needle, so that the valve can be operated to deploy the needle and deliver the medication through the needle when the user is ready for the injection. The valve can also be operated to retract the needle when the dose is complete.

Abstract: A method and device for intradermal delivery of a reconstituted powdered medicament. The device includes a chamber, which is in fluid communication with a microdevice, e.g. microabrader or one or more microneedles. A cartridge containing the powdered medicament may be located within said chamber. At least one burstable membrane retains a powdered medicament within the housing. The method involves the steps of positioning the device at a delivery site on the skin of a patient and intradermally administering the medicament by dispensing a diluent from a diluent source an through inlet port to rupture the membranes, reconstitute the powdered medicament and deliver the reconstituted medicament through the microdevice to the dermal region of the skin.

Abstract: A method of preparing a pharmaceutical composition is described, comprising 1) atomizing a liquid formulation of a therapeutic agent to produce an atomized formulation; 2) freezing said atomized formulation to form solid particles; and 3) drying said solid particles at about atmospheric pressure to produce a powder, wherein said drying is performed in the presence of vibration, internals, mechanical stirring, or a combination thereof. Another method is described, comprising 1) atomizing a liquid formulation of a therapeutic agent to produce an atomized formulation; 2) freezing said atomized formulation to form solid particles; and 3) drying said solid particles to produce a powder; wherein the atomized formulation comprises droplets having an average mean diameter of between about 35? and about 300?, and/or the powder comprises dried particles having an average mean diameter of between about 35? and about 300?. Compositions made by the above methods, and methods of using the compositions, are also described.

Abstract: A method of preparing a pharmaceutical composition is described, comprising 1) atomizing a liquid formulation of a therapeutic agent to produce an atomized formulation; 2) freezing said atomized formulation to form solid particles; and 3) drying said solid particles at about atmospheric pressure to produce a powder, wherein said drying is performed in the presence of vibration, internals, mechanical stirring, or a combination thereof. Another method is described, comprising 1) atomizing a liquid formulation of a therapeutic agent to produce an atomized formulation; 2) freezing said atomized formulation to form solid particles; and 3) drying said solid particles to produce a powder; wherein the atomized formulation comprises droplets having an average mean diameter of between about 35? and about 300?, and/or the powder comprises dried particles having an average mean diameter of between about 35? and about 300?. Compositions made by the above methods, and methods of using the compositions, are also described.

Abstract: A method of preparing a pharmaceutical composition is described, comprising 1) atomizing a liquid formulation of a therapeutic agent to produce an atomized formulation; 2) freezing said atomized formulation to form solid particles; and 3) drying said solid particles to produce a powder. Compositions made by the above methods, and methods of using the compositions, are also described.

Abstract: Solid substrates for cell culture are UV-cross-linked PVA-based hydrogel polymer particles. The particles are biocompatible with living cells and support cell adherence. Bioaffecting molecules may be reversibly entrapped within the particles. The particles are capable of forming self-assembled aggregates with cultured cells in aqueous suspension. Preferably, the PVA-based polymer is PVA-SbQ.

Abstract: A molding apparatus and molding method are provided for molding of small objects from a thermoplastic elastomer. The apparatus includes a heated transfer plate assembly, an insulation plate assembly adjacent the transfer plate assembly and a cooled cavity plate assembly. The transfer plate assembly is heated sufficiently to maintain a thermoplastic elastomer in a molten state. The cavity plate assembly is cooled sufficiently to solidify a thermoplastic elastomer injected into cavities of the cavity plate assembly.

Abstract: A method of preparing a pharmaceutical composition is described, comprising 1) atomizing a liquid formulation of a therapeutic agent to produce an atomized formulation; 2) freezing said atomized formulation to form solid particles; and 3) drying said solid particles at about atmospheric pressure to produce a powder, wherein said drying is performed in the presence of vibration, internals, mechanical stirring, or a combination thereof. Another method is described, comprising 1) atomizing a liquid formulation of a therapeutic agent to produce an atomized formulation; 2) freezing said atomized formulation to form solid particles; and 3) drying said solid particles to produce a powder; wherein the atomized formulation comprises droplets having an average mean diameter of between about 35&mgr; and about 300&mgr;, and/or the powder comprises dried particles having an average mean diameter of between about 35&mgr; and about 300&mgr;.

Abstract: A method of preparing a pharmaceutical composition is described, comprising 1) atomizing a liquid formulation of a therapeutic agent to produce an atomized formulation; 2) freezing said atomized formulation to form solid particles; and 3) drying said solid particles at about atmospheric pressure to produce a powder, wherein said drying is performed in the presence of vibration, internals, mechanical stirring, or a combination thereof. Another method is described, comprising 1) atomizing a liquid formulation of a therapeutic agent to produce an atomized formulation; 2) freezing said atomized formulation to form solid particles; and 3) drying said solid particles to produce a powder; wherein the atomized formulation comprises droplets having an average mean diameter of between about 35&mgr; and about 300&mgr;, and/or the powder comprises dried particles having an average mean diameter of between about 35&mgr; and about 300&mgr;.

Abstract: A molding apparatus and molding method are provided for molding of small objects from a thermoplastic elastomer. The apparatus includes a heated transfer plate assembly, an insulation plate assembly adjacent the transfer plate assembly and a cooled cavity plate assembly. The transfer plate assembly is heated sufficiently to maintain a thermoplastic elastomer in a molten state. The cavity plate assembly is cooled sufficiently to solidify a thermoplastic elastomer injected into cavities of the cavity plate assembly.

Abstract: A hydrostatic injection molding apparatus and process are provided for thermoplastic materials, especially thermoplastic elastomers. The apparatus includes a hot pot plate with a transfer chamber for receiving a thermoplastic material. The hot pot plate is heated to maintain the thermoplastic material in the transfer chamber in a molten state. A cavity plate is positioned adjacent the transfer pot plate, the cavity plate is formed with a plurality of cavities extending therein. Gates are formed in the hot pot plate and the cavity plate. The gates in the respective plates register with one another to provide communication between the transfer chamber and the cavities. The cavity plate is cooled to enable a rapid curing of the thermoplastic material therein.

Abstract: A composition is provided which comprises a functionalized poly(phenylene ether) resin, poly(arylene sulfide) resin, epoxy functional alpha-olefin elastomer, elastomeric block copolymer, and a metal salt. The composition is preferably prepared by premixing a poly(phenylene ether) resin with an organic acid and a vinyl aromatic-diene block copolymer to form a premix, and then compounding the premix with an epoxy functional alpha-olefin elastomer, a poly(arylene sulfide) resin and a metal salt of an organic acid. The composition has enhanced levels of mechanical properties such as impact strength, and is suitable for making molded articles such as vertical automotive body panels.

Abstract: A medical article is molded from a silane-grafted polyolefin copolymer and crosslinked to have improved compression set and sealability so that the crosslinked article can be sterilized with substantially no changes in size or shape.

Abstract: A process for making a closure assembly includes placing a closure cap portion in a compression mold, introducing a melt of elastomer, pressing the melt into a septum against the cap and applying a foil barrier against the septum. The process may be performed in a rotary compression molding apparatus.

Abstract: Compositions are provided for compatibilized blends comprising compatibilizing poly(phenylene ether) resins and epoxy-functional polyolefins that exhibit improved resistance to delamination while providing high impact strength and other improved physical properties. Articles made from the compositions are useful for automotive lighting and under hood components.

Abstract: Compositions are provided which comprise a poly(phenylene ether) resin, a poly(arylene sulfide) resin and an ortho ester compound. The compositions can further comprise compatibilizing agents and reinforcing fillers to provide compositions that exhibit low flash molding characteristics. Articles molded from these compositions are useful in the electrical connector industry.