Patents by Inventor Robin John Brown

Robin John Brown has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods, agents, and compound screening assays for inducing differentiation of undifferentiated mammalian cells into osteoblasts
    Patent number: 8883425
    Abstract: The present invention relates to methods, agents and compound screening assays for inducing differentiation of undifferentiated mammalian cells into osteoblasts. The invention thus provides a method, comprising contacting a compound with a polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID No: 194-309; and measuring a compound-polypeptide property related to the differentiation of said cells. The invention further relates to a bone formation enhancing pharmaceutical composition, and the use thereof in treating and/or preventing a disease involving a systemic or local decrease in mean bone density in a subject. Furthermore, the invention relates to a method for the in vitro production of bone tissue.
    Type: Grant
    Filed: October 30, 2012
    Date of Patent: November 11, 2014
    Assignee: Galapagos N.V.
    Inventors: Luc Juliaan Corina Van Rompaney, Peter Herwig Maria Tomme, Robin John Brown
  • Methods for inducing differentiation of undifferentiated mammalian cells into osteoblasts
    Patent number: 8338124
    Abstract: The present invention relates to in vivo and in vitro methods, agents and compound screening assays for inducing differentiation of undifferentiated mammalian cells into osteoblasts, including bone formation enhancing pharmaceutical compositions, and the use thereof in treating and/or preventing a disease involving a systemic or local decrease in mean bone density in a subject.
    Type: Grant
    Filed: November 21, 2009
    Date of Patent: December 25, 2012
    Assignee: Galapagos N.V.
    Inventors: Luc Juliaan Corina Van Rompaey, Peter Herwig Maria Tomme, Robin John Brown
  • Methods, agents, and compound screening assays for inducing differentiation of undifferentiated mammalian cells into osteoblasts
    Patent number: 8318137
    Abstract: The present invention relates to methods, agents and compound screening assays for inducing differentiation of undifferentiated mammalian cells into osteoblasts. The invention thus provides a method, comprising contacting a compound with a polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID No: 194-309; and measuring a compound-polypeptide property related to the differentiation of said cells. The invention further relates to a bone formation enhancing pharmaceutical composition, and the use thereof in treating and/or preventing a disease involving a systemic or local decrease in mean bone density in a subject. Furthermore, the invention relates to a method for the in vitro production of bone tissue.
    Type: Grant
    Filed: October 30, 2009
    Date of Patent: November 27, 2012
    Assignee: Galapagos N.V.
    Inventors: Luc Juliaan Corina Van Rompaey, Peter Herwig Maria Tomme, Robin John Brown
  • Methods for Inducing Differentiation of Undifferentiated Mammalian Cells Into Osteoblasts
    Publication number: 20100093833
    Abstract: The present invention relates to in vivo and in vitro methods, agents and compound screening assays for inducing differentiation of undifferentiated mammalian cells into osteoblasts, including bone formation enhancing pharmaceutical compositions, and the use thereof in treating and/or preventing a disease involving a systemic or local decrease in mean bone density in a subject.
    Type: Application
    Filed: November 21, 2009
    Publication date: April 15, 2010
    Applicant: GALAPAGOS NV
    Inventors: Luc Juliaan Corina Van Rompaey, Peter Herwig Maria Tomme, Robin John Brown
  • Methods, Agents, and Compound Screening Assays for Inducing Differentiation of Undifferentiated Mammalian Cells into Osteoblasts
    Publication number: 20100087509
    Abstract: The present invention relates to methods, agents and compound screening assays for inducing differentiation of undifferentiated mammalian cells into osteoblasts. The invention thus provides a method, comprising contacting a compound with a polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID No: 194-309; and measuring a compound-polypeptide property related to the differentiation of said cells. The invention further relates to a bone formation enhancing pharmaceutical composition, and the use thereof in treating and/or preventing a disease involving a systemic or local decrease in mean bone density in a subject. Furthermore, the invention relates to a method for the in vitro production of bone tissue.
    Type: Application
    Filed: October 30, 2009
    Publication date: April 8, 2010
    Applicant: GALAPAGOS N.V.
    Inventors: Luc Juliaan Corina Van Rompaey, Peter Herwig Maria Tomme, Robin John Brown
  • Methods for inducing differentiation of undifferentiated mammalian cells into osteoblasts
    Patent number: 7638288
    Abstract: The present invention relates to in vivo and in vitro methods, agents and compound screening assays for inducing differentiation of undifferentiated mammalian cells into osteoblasts, including bone formation enhancing pharmaceutical compositions, and the use thereof in treating and/or preventing a disease involving a systemic or local decrease in mean bone density in a subject.
    Type: Grant
    Filed: June 29, 2006
    Date of Patent: December 29, 2009
    Assignee: Galapagos N.V.
    Inventors: Luc Juliaan Corina Van Rompaey, Peter Herwig Maria Tomme, Robin John Brown
  • Methods, agents, and compound screening assays for inducing differentiation of undifferentiatied mammalian cells into osteoblasts
    Patent number: 7615626
    Abstract: The present invention relates to methods, agents and compound screening assays for inducing differentiation of undifferentiated mammalian cells into osteoblasts. The invention thus provides a method, comprising contacting a compound with a polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID No: 194-309; and measuring a compound-polypeptide property related to the differentiation of said cells. The invention further relates to a bone formation enhancing pharmaceutical composition, and the use thereof in treating and/or preventing a disease involving a systemic or local decrease in mean bone density in a subject. Furthermore, the invention relates to a method for the in vitro production of bone tissue.
    Type: Grant
    Filed: October 23, 2006
    Date of Patent: November 10, 2009
    Assignee: Galapagos N.V.
    Inventors: Luc Juliaan Corina Van Rompaey, Peter Herwig Maria Tomme, Robin John Brown