Patents by Inventor Robin Levis

Robin Levis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Infectious Sindbis virus vectors
    Patent number: 5217879
    Abstract: Compositions and methods are disclosed for expressing heterologous coding sequences in host cells. The compositions include infectious Sindbis virus RNA molecules containing at least one heterologous coding sequence inserted within the structural region of the Sindbis virus genome. RNA molecules consisting essentially of a Sindbis virus junction region are also provided. Methods utilizing the novel compositions of the present invention to express heterologous coding sequences in transformed host cells are provided. Methods for producing infectious Sindbis virus particles containing infectious Sindbis virus RNA molecules comprising at least one heterologous coding sequence are provided.This invention was made with government support under grant numbers AI24134, AI11377 and AG05681 awarded by the National Institutes of Health. The government has certain rights in the invention.
    Type: Grant
    Filed: December 27, 1991
    Date of Patent: June 8, 1993
    Assignee: Washington University
    Inventors: Henry V. Huang, Robin Levis, Charles M. Rice, Sondra Schlesinger, Ping Shen, Cheng Xiong
  • Sindbis virus vectors
    Patent number: 5091309
    Abstract: The present invention relates to RNA vectors comprising Sindbis virus DI RNA having inserted therein heterologous RNA. The vectors of the present invention provide for the cloning and expression of heterologous RNA in eucaryotic cells as well as the packaging of heterologous RNA into viral particles in the presence of helper virus. Transformed cells and genetically altered alphavirus particles comprising alphavirus DI RNA having inserted therein heterologous RNA are also provided.
    Type: Grant
    Filed: August 17, 1989
    Date of Patent: February 25, 1992
    Assignee: Washington University
    Inventors: Sondra Schlesinger, Henry V. Huang, Robin Levis, Barbara Weiss, Manuel Tsiang