Abstract: Matrix metalloproteinases (MMPs) are a group of enzymes that have been implicated in the pathological destruction of connective tissue and basement membranes. These zinc containing endopeptidases consist of several subsets of enzymes including collagenases, stromelysins and gelatinases. TNF-&agr; converting enzyme (TACE), a pro-inflammatory cytokine, catalyzes the formation of TNF-&agr; from membrane bound TNF-&agr; precursor protein. It is expected that small molecule inhibitors of MMPs and TACE therefore have the potential for treating a variety of disease states. The present invention provides low molecular weight, non-peptide inhibitors of matrix metalloproteinases (MMPs) and TNF-&agr; converting enzyme (TACE) for the treatment of arthritis, tumor metastasis, tissue ulceration, abnormal wound healing, periodontal disease, bone disease, diabetes (insulin resistance) and HIV infection.

Abstract: A decorative static dissipative high pressure laminate having a plurality of consolidated thermosetting resin impregnated layers including a core and a decor surface layer to provide a surface resistance no greater than 2.times.10.sup.9. The core comprises at least one thermosetting resin impregnated paper core sheet and at least one special thermosetting resin impregnated core sheet of predominately paper fibers and a small quantity of stainless steel fibers irregularly distributed among the paper fibers.