Abstract: An example system includes a vehicle having at least one network zone; a policy manager circuit structured to interpret a policy comprising an external data routing description, wherein the policy includes a default policy value; a configuration circuit structured to configure a gatekeeper interface circuit in response to the external data routing description and the external data service description; the gatekeeper interface circuit interposed between the at least one network zone and at least one external communication portal selectively couplable to an external device; and wherein the gatekeeper interface circuit is structured to regulate communications between end points of the first network zone and the at least one external communication portal, and to regulate communications between end points of the second network zone and the at least one external communication portal.

Abstract: An example system includes a vehicle having an Ethernet based network and a controller area network (CAN) based network; a CAN vehicle control device disposed onboard the vehicle and structured to control operation of a component of the vehicle; an Ethernet vehicle control device disposed onboard the vehicle and structured to electrically communicate with the CAN vehicle control device; an Ethernet switch disposed onboard the vehicle and having a plurality of physical ports connected to the Ethernet based network; a CAN gateway disposed onboard the vehicle and connected to the CAN based network and the Ethernet switch; and a network convergence circuit defined at least in part by the Ethernet switch and/or the CAN gateway, and structured to facilitate electronic communications between the Ethernet vehicle control device and the CAN vehicle control device.

Abstract: An example system includes a vehicle having a first network zone and a second network zone of a different type than the first network zone, a converged network device (CND) interposed between the zones, where the CND includes a policy management circuit that interprets a policy including a network regulation description, a configuration circuit that configures network interface circuit(s) in response to the policy, and the interface circuit(s) that regulate communications between end points of the network zones.

Abstract: An example system includes a vehicle having at least one network zone; a policy manager circuit structured to interpret a policy including a local domain name server (DNS), an authorization description, and a firewall configuration description; a configuration circuit structured to configure a gatekeeper interface circuit in response to the policy; and a gatekeeper interface circuit interposed between the at least one network zone and an external communication portal selectively couplable to an external device, and further structured to regulate communications between end points of the at least one network zone and the external communication portal.

Abstract: An example system includes a vehicle having at least one network zone; a policy manager circuit structured to interpret a policy comprising an external data routing description, wherein the policy includes a default policy value; a configuration circuit structured to configure a gatekeeper interface circuit in response to the external data routing description and the external data service description; the gatekeeper interface circuit interposed between the at least one network zone and at least one external communication portal selectively couplable to an external device; and wherein the gatekeeper interface circuit is structured to regulate communications between end points of the first network zone and the at least one external communication portal, and to regulate communications between end points of the second network zone and the at least one external communication portal.

Abstract: An apparatus for managing vehicle data collection including a remote access execution circuit, a property translation circuit, a parameter acquisition circuit, a remote operation circuit, and a parameter conditioning circuit. The remote access execution circuit interprets a remote access request value including a requested vehicle property and/or a vehicle function value. The property translation circuit determines: a property request value responsive to the requested vehicle property; and/or an actuator command value responsive to the vehicle function value. The parameter acquisition circuit interprets vehicle parameter values responsive to the property request value. The remote operation circuit provides the actuator command value to a vehicle network zone endpoint. The parameter conditioning circuit generates, responsive to the property request value, vehicle property data from the vehicle parameter values. The vehicle property data corresponds to the requested vehicle property.

Abstract: An example system includes a vehicle having a first network zone and a second network zone of a different type than the first network zone, a converged network device (CND) interposed between the zones, where the CND includes a policy management circuit that interprets a policy including a network regulation description, a configuration circuit that configures network interface circuit(s) in response to the policy, and the interface circuit(s) that regulate communications between end points of the network zones.

Abstract: An example system includes a vehicle having at least one network zone, and a policy manager circuit that interprets a policy including a local DNS, an authorization description, and a firewall configuration description. The system includes a configuration circuit that configures a gatekeeper interface circuit in response to the policy, where the gatekeeper interface circuit is interposed between one of the network zones and an external communication portal, and regulates communications between end points of the network zone and the external communication portal.

Abstract: The invention features methods of diagnosing a subject as having, or at risk of developing ALS by determining the frequency of Gems in cells obtained from the subject. These methods include diagnosing the severity or monitoring the progression of ALS by determining the Gem frequency in a subject. Also, the invention features methods of identifying compounds useful for the treatment of ALS as well as methods for the treatment of ALS.

Abstract: An electrical contact includes a crimping section for securing a wire and a flute section for receiving a pin. The flute section includes fixed engagement members and a resilient cantilever member that engages the pin within the flute section.

Abstract: An electrical connector assembly for a fuel injector includes a receptacle and mating plug. The plug is formed with side channels within which socket contacts at the end of an electrical wire or conductor may be snap fit. The receptacle includes side loading wedges aligned with the side channels of the plug to place a lateral load or compressive force on the socket contacts. The plug is formed with strain relief wedges that place a vertical load or compressive force on the socket contacts or wire insulation and conductor held therein. The plug and receptacle are formed with a key and keyway for proper orientation. An external latch on the receptacle captures the fully inserted plug.

Abstract: The invention provides methods and reagents for isolating functional ribonucleoprotein complexes, such as functional eukaryotic spliceosomal complexes. The methods and reagents can be used, e.g., in diagnostic methods for determining the presence of abnormal ribonucleoprotein complexes.

Abstract: The present invention features methods for increasing levels of nuclear export of mRNA by providing recombinant mammalian export factor. Also featured are methods for preparing metazoan or mammalian cells with recombinant factor ALY that are useful for facilitating mRNA export. The export factor ALY binds mRNA in a non sequence specific manner and the ALY-mRNA complex is exported more efficiently than unbound mRNA. The addition of excess ALY to metazoan or mammalian cell results in increased mRNA export, increased gene expression and increased production of recombinant proteins.