Patents by Inventor Robin W. Spencer

Robin W. Spencer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Assay for activity of the ActRIIB kinase
    Publication number: 20030219846
    Abstract: The present invention relates to kinase assays, and specifically to novel kinase assay methods using a novel target peptide for measuring the activity and/or modulation of activity of the ActRIIB kinase protein.
    Type: Application
    Filed: February 14, 2003
    Publication date: November 27, 2003
    Applicant: Pfizer Inc.
    Inventors: Philip A. Krasney, Michael Norcia, Barbara A. O'Connor, Robin W. Spencer
  • Aromatic pyrrolidine amide prolyl endopeptidase inhibitors
    Patent number: 5847155
    Abstract: A series of aromatic pyrrolidine derivatives and suitable pharmaceutically acceptable salts thereof are disclosed. These compounds are useful as PEP inhibitors in the treatment of Alzheimer's disease, amnesia, dementia, anxiety ischemia, or stroke.
    Type: Grant
    Filed: January 26, 1996
    Date of Patent: December 8, 1998
    Assignee: Pfizer Inc
    Inventors: W. Stephen Faraci, Arthur A. Nagel, Robin W. Spencer, Fredric J. Vinick
  • Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors
    Patent number: 5158936
    Abstract: Thiol protease inhibitors are disclosed having the formula: ##STR1## or an optical isomer thereof, or a pharmaceutically acceptable salt thereof, wherein:n is 0 or 1;m is 0, 1 or 2;X is H or an N-protecting group;each Y is independently an optionally protected .alpha.-amino acid residue;R is an optionally protected .alpha.-amino acid side chain that is H or CH.sub.3 or that is bonded to the .alpha.-carbon atom to which it is attached by a methylene, methine or phenyl radial; andR' is optionally substituted aryl.
    Type: Grant
    Filed: May 15, 1991
    Date of Patent: October 27, 1992
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: Alexander Krantz, Heinz W. Pauls, Roger A. Smith, Robin W. Spencer
  • Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors
    Patent number: 5055451
    Abstract: Thiol protease inhibitors are disclosed having the formula: ##STR1## or an optical isomer thereof, or a pharmaceutically acceptable salt thereof, wherein:n is 0 or 1;m is 0, 1 or 2;X is H or an N-protecting group;each Y is independently an optionally protected .alpha.-amino acid residue;R is an optionally protected .alpha.-amino acid side chain that is H or CH.sub.3 or that is bonded to the .alpha.-carbon atom to which it is attached by a methylene, methine or phenyl radical; andR' is optionally substituted aryl.
    Type: Grant
    Filed: December 7, 1987
    Date of Patent: October 8, 1991
    Assignee: Syntex Inc.
    Inventors: Alexander Krantz, Heinz W. Pauls, Roger A. Smith, Robin W. Spencer
  • Ynenolactone protease inhibitors
    Patent number: 4602006
    Abstract: Compounds of the formula ##STR1## wherein n is 1-3; R.sup.1, R.sup.2 and R.sup.3 are the same or different and are hydrogen, lower alkyl, lower alkenyl, lower alkynyl, aryl or aryl lower alkyl wherein when aryl is phenyl it is unsubstituted or independently substituted with one or more halo, lower alkyl or lower alkoxy groups; and R.sup.4 is hydrogen, lower alkyl, lower alkenyl, lower alkynyl, trialkylsilyl, aryl or aryl lower alkyl wherein when aryl is phenyl it is unsubstituted or independently substituted by one or more halo, lower alkyl or lower alkoxy groups; excluding those compounds wherein R.sup.1 and R.sup.2 are hydrogen and R.sup.4 is ethyl, propyl or butyl. These compounds are useful as protease inhibitors.
    Type: Grant
    Filed: May 9, 1984
    Date of Patent: July 22, 1986
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: Alexander Krantz, Tim F. Tam, Robin W. Spencer