Abstract: A patient interface including a plenum chamber, a first seal-forming structure for forming a seal around the patient's mouth, and a second seal-forming structure for forming a seal around the patient's nares. The patient interface further includes at least one stopper rib disposed in the cavity of the plenum chamber spaced apart from the first seal-forming structure in a rest position. The first seal-forming structure configured to contact the at least one stopper rib in an operational position. The at least one stopper rib configured to oppose compression of the first seal-forming structure in an anterior direction. The second seal-forming structure is not configured to contact the at least one stopper rib.

Abstract: The present invention relates to RNA constructs, and particularly, although not exclusively, to mRNA constructs and saRNA replicons and to nucleic acids and expression vectors encoding such RNA constructs. The invention extends to the use of such RNA constructs in therapy, for example in treating diseases and/or in vaccine delivery. The invention extends to pharmaceutical compositions comprising such RNA constructs, and methods and uses thereof.

Abstract: A patient interface including a positioning and stabilizing structure that is configured to maintain a first seal-forming structure and a second seal-forming structure in a therapeutically effective position. The positioning and stabilizing structure comprises a frame coupled to the plenum chamber. The frame includes a central portion coupled to the plenum chamber outside of the cavity. The frame also includes a pair of arms that extend away from the central portion in a posterior direction past the second seal-forming structure. The pair of arms are more flexible than the central portion. The positioning and stabilizing structure also includes headgear straps coupled to the frame, which configured to provide a tensile force to the first seal-forming structure and to the second seal-forming structure into the patient's face via the frame.

Abstract: An insect and arachnid trap (10, 100) comprises a substrate (12) having a top surface (14) onto which a sticky substance (24) is deposited. One embodiment of the trap (10) is provided with a reinforcing rib (26) to reinforce the thin sheet substrate. The trap (10, 100) may also have a channel (22, 22) into which the sticky substance (24) is deposited. The top surface (14) may have a smooth finish and be inclined to the horizontal in order to prevent trapped insects and arachnids from extricating themselves from the sticky substance. The sticky substance is a composition which includes polybutene oil and polyisobutylene. The sticky substance preferably includes 5-15 wt % polyisobutylene. This sticky substance in combination with the channel and smooth top surface provides an insect and arachnid trap which is more effective than known examples. The reinforcing rib ensures that the substrate (12) does not fold back upon itself when handled after use. Contact with trapped insects or arachnids is thus avoided.

Abstract: An insect and arachnid trap (10, 100) comprises a substrate (12) having a top surface (14) onto which a sticky substance (24) is deposited. One embodiment of the trap (10) is provided with a reinforcing rib (26) to reinforce the thin sheet substrate. The trap (10, 100) may also have a channel (22, 22) into which the sticky substance (24) is deposited. The top surface (14) may have a smooth finish and be inclined to the horizontal in order to prevent trapped insects and arachnids from extricating themselves from the sticky substance. The sticky substance is a composition which includes polybutene oil and polyisobutylene. The sticky substance preferably includes 5-15 wt % polyisobutylene. This sticky substance in combination with the channel and smooth top surface provides an insect and arachnid trap which is more effective than known examples. The reinforcing rib ensures that the substrate (12) does not fold back upon itself when handled after use. Contact with trapped insects or arachnids is thus avoided.