Patents by Inventor Robin Weiss

Robin Weiss has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DNA encoding the T cell surface protein CD4 and use of fragments of CD4 in the treatment of AIDS
    Patent number: 6570000
    Abstract: A single-stranded nucleic acid molecule which encodes an amino acid sequence comprising at least a portion of a T4 glycoprotein is provided. Additionally, amino acid sequences which comprise at least a portion of a T4 glycoprotein and are useful as a prophylaxis for treating a subject with acquired immune deficiency syndrome are provided. These amino acid sequences, which are capable of specifically forming a complex with a human immunodeficiency virus envelope glycoprotein and which are soluble in an aqueous solution may be administered to a subject infected with a human immunodeficiency virus so as to block the human immunodeficiency virus from binding to T4+ cells. Monoclonal antibodies directed to the water-soluble amino acid sequences of the present invention may be used as vaccines for immunizing a subject against acquired immune deficiency syndrome.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: May 27, 2003
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Paul J. Maddon, Dan R. Littman, Leonard Chess, Richard Axel, Robin Weiss
  • DNA encoding the T cell surface protein T4 and use of fragments of T4 in the treatment of AIDS
    Patent number: 6093539
    Abstract: This invention provides an isolated single-stranded nucleic acid which encodes an aqueous-soluble polypeptide comprising at least a portion of a human T4 glycoprotein, which portion specifically forms a complex with a human immunodeficiency virus envelope glycoprotein.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: July 25, 2000
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Paul J. Maddon, Dan R. Littman, Leonard Chess, Richard Axel, Robin Weiss, J. Steven McDougal
  • DNA encoding the T cell surface protein T4 and use of fragments of T4 in the treatment of AIDS
    Patent number: 5958678
    Abstract: A single-stranded nucleic acid molecule which encodes an amino acid sequence comprising at least a portion of a T4 glycoprotein is provided. Additionally, amino acid sequences which comprise at least a portion of a T4 glycoprotein and are useful as a prophylaxis for treating a subject with acquired immune deficiency syndrome are provided. These amino acid sequences, which are capable of specifically forming a complex with a human immunodeficiency virus envelope glycoprotein and which are soluble in an aqueous solution may be administered to a subject infected with a human immunodeficiency virus so as to block the human immunodeficiency virus from binding to T4.sup.+ cells.Monoclonal antibodies directed to the water-soluble amino acid sequences of the present invention may be used as vaccines for immunizing a subject against acquired immune deficiency syndrome.
    Type: Grant
    Filed: December 12, 1994
    Date of Patent: September 28, 1999
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Paul J. Maddon, Dan R. Littman, Leonard Chess, Richard Axel, Robin Weiss, J. Steven McDougal
  • DNA encoding the T cell surface protein T4 and use of fragments of T4 in the treatment of AIDS
    Patent number: 5871913
    Abstract: A single-stranded nucleic acid molecule which encodes the amino acid sequence comprising at least a portion of a T4 glycoprotein is provided. Additionally, amino acid sequences which comprise at least a portion of a T4 glycoprotein and are useful as a prophylaxis for treating a subject with acquired immune deficiency syndrome are provided. These amino acid sequences, which are capable of specifically forming a complex with a human immunodeficiency virus glycoprotein and which are soluble in an aqueous solution may be administered to a subject infected with a human immunodeficiency virus so as to block the human immunodeficiency virus from binding to T4 cells. Monoclonal antibodies directed to the water-soluble amino acid sequences of the present invention may be used as vaccines for immunizing a subject against acquired immune deficiency syndrome.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: February 16, 1999
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Paul J. Maddon, Dan R. Littman, Leonard Chess, Richard Axel, Robin Weiss, J. Steven McDougal
  • Soluble forms of the T cell surface protein CD4
    Patent number: 5126433
    Abstract: A single-stranded nucleic acid molecule which encodes an amino acid sequence comprising at least a portion of a T4 glycoprotein is provided. Additionally, amino acid sequences which comprise at least a portion of a T4 glycoprotein and are useful as a prophylaxis for treating a subject with acquired immune deficiency syndrome are provided. These amino acid sequences, are capable of specifically forming a complex with a human immunodeficiency virus envelope glycoprotein and which are soluble in an aqueous solution. Monoclonal antibodies directed to the water-soluble amino acid sequences of the present invention may be used as vaccines for immunizing a subject against acquired immune deficiency syndrome.
    Type: Grant
    Filed: October 23, 1987
    Date of Patent: June 30, 1992
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Paul J. Maddon, Leonard Chess, Richard Axel, Robin Weiss, Dan R. Littman, J. Steven McDougal
  • Viral isolates and their use in diagnosis
    Patent number: 4912030
    Abstract: Samples e.g. transfusion blood, are assayed for antibodies to retroviruses, e.g. AIDS virus, using an insolubilized antigen comprising retrovirus antigens bound to globulin, the globulin itself being bound to an inert solid support; and an immunoglobulin which contains specific antibody to the retrovirus antigens and which is labelled with a revealing label, and the soluble phase is then separated from the insoluble phase and the quantity of revealing label associated with either the soluble or the insoluble phase determined.The sue of labelled antibody in competition with test sera for binding on the insolublized antigen permits better identification of antibody containing specimens. The retroviruses may be a human T-lymphotropic retrovirus HTLV-I, II or III or a new retrovirus isolate CBL-1 etiologically related to AIDS.
    Type: Grant
    Filed: April 5, 1988
    Date of Patent: March 27, 1990
    Assignee: Institute of Cancer Research
    Inventors: Robin Weiss, Richard Tedder, Rachanee Cheingsong-Popov, Bridget Ferns