Patents by Inventor Robyn Heather Wallace

Robyn Heather Wallace has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nucleic acid encoding SCN1A variant
    Patent number: 7989182
    Abstract: A method of identifying a subject predisposed to a disorder associated with ion channel dysfunction, comprising ascertaining whether at least one of the genes encoding ion channel subunits in said subject has undergone a mutation event such that a cDNA derived from said subject has the sequence set forth in one of SEQ ID NOS: 1-134.
    Type: Grant
    Filed: January 29, 2010
    Date of Patent: August 2, 2011
    Assignee: Bionomics Limited
    Inventors: John Charles Mulley, Louise Anne Harkin, Leanne Michelle Dibbens, Robyn Heather Wallace, Hilary Anne Phillips, Sarah Elizabeth Heron, Samuel Frank Berkovic, Ingrid Eileen Scheffer
  • MUTATIONS IN ION CHANNELS
    Publication number: 20100136623
    Abstract: A method of identifying a subject predisposed to a disorder associated with ion channel dysfunction, comprising ascertaining whether at least one of the genes encoding ion channel subunits in said subject has undergone a mutation event such that a cDNA derived from said subject has the sequence set forth in one of SEQ ID NOS: 1-134.
    Type: Application
    Filed: January 29, 2010
    Publication date: June 3, 2010
    Inventors: John Charles Mulley, Louise Anne Harkin, Leanne Michelle Dibbens, Robyn Heather Wallace, Hilary Anne Phillips, Sarah Elizabeth Heron, Samuel Frank Berkovic, Ingrid Eileen Scheffer
  • Nucleic acids encoding mutations in sodium channels related to epilepsy
    Patent number: 7709225
    Abstract: An isolated nucleic acid molecule encoding a mutant alpha subunit of a mammalian voltage-gated sodium channel, wherein a mutation event selected from the group consisting of point mutations, deletions, insertions and rearrangements has occurred and said mutation event disrupts the functioning of an assembled sodium channel comprising this mutated subunit so as to produce an epilepsy phenotype, with the proviso that the mutation event is not a C2624T transition or a G4943A transition.
    Type: Grant
    Filed: October 31, 2005
    Date of Patent: May 4, 2010
    Assignee: Bionomics Limited
    Inventors: Robyn Heather Wallace, John Charles Mulley, Samuel Frank Berkovic
  • Method of diagnosing epilepsy
    Patent number: 7282336
    Abstract: An isolated nucleic acid molecule encoding a mutant alpha subunit of a mammalian voltage-gated sodium channel, wherein a mutation event selected from the group consisting of point mutations, deletions, insertions and rearrangements has occurred and said mutation event disrupts the functioning of an assembled sodium channel comprising this mutated subunit so as to produce an epilepsy phenotype, polypeptides encoded by said nucleic molecule and uses of these molecules in preparing animal models and in diagnostic applications.
    Type: Grant
    Filed: October 31, 2005
    Date of Patent: October 16, 2007
    Assignee: Bionomics Limited
    Inventors: Robyn Heather Wallace, John Charles Mulley, Samuel Frank Berkovic
  • Mutation associated with epilepsy
    Patent number: 7157569
    Abstract: An isolated mammalian DNA molecule encoding a mutant ?-aminobutyric acid (GABA) receptor subunit, wherein a mutation event selected from the group consisting of point mutations, deletions, insertions and rearrangements has occurred and said mutation event disrupts the functioning of an assembled GABA receptor, or an otherwise functional fragment or homologue thereof.
    Type: Grant
    Filed: June 20, 2001
    Date of Patent: January 2, 2007
    Assignee: Bionomics Limited
    Inventors: Robyn Heather Wallace, John Charles Mulley, Samuel Frank Berkovic, Louise Anne Harkin, Leanne Michelle Dibbens
  • Sodium-channel alpha1-subunit and their polypeptides and their treatment of generalized epilepsy with febrile seizures plus
    Patent number: 7078515
    Abstract: The mutations D188V, V1353L, I1656M in the neuronal gene sodium-channel alpha1-subunit, SCN1A, are disclosed. The methods of using their associated polypeptides for treating sodium channel dysfunction disorders including generalized epilepsy are also disclosed.
    Type: Grant
    Filed: December 20, 2001
    Date of Patent: July 18, 2006
    Assignee: Bionomics Limited
    Inventors: Robyn Heather Wallace, John Charles Mulley, Samuel Frank Berkovic
  • Novel mutation
    Publication number: 20040191791
    Abstract: An isolated nucleic acid molecule encoding a mutant mammalian beta-1 subunit of a voltage-gated sodium channel wherein a mutation event has occurred and said mutation event disrupts the functioning of an assembled sodium channel so as to produce an epilepsy phenotype, with the proviso that said mutation event is not one which results in a C121W substitution in the encoded polypeptide.
    Type: Application
    Filed: May 5, 2004
    Publication date: September 30, 2004
    Inventors: Robyn Heather Wallace, John Charles Mulley, Ingrid Eileen Scheffer
  • Sodium-channel alpha1-subunit and their polypeptides and their treatment of generalised epilepsy with febrile seizures plus
    Publication number: 20040110706
    Abstract: The mutations D188V, V1353L, I1656M in the neuronal gene sodium-channel alpha1-subunit, SCN1A, are disclosed. The methods of using their associated polypeptides for treating sodium channel dysfunction disorders including generalised epilepsy are also disclosed.
    Type: Application
    Filed: October 8, 2003
    Publication date: June 10, 2004
    Inventors: Robyn Heather Wallace, John Charles Mulley, Samuel Frank Berkovic
  • Mutation associated with epilepsy
    Publication number: 20040038236
    Abstract: An isolated mammalian DNA molecule encoding a mutant &ggr;-aminobutyric acid (GABA) receptor subunit, wherein a mutation event selected from the group consisting of point mutations, deletions, insertions and rearrangements has occurred and said mutation event disrupts the functioning of an assembled GABA receptor, or an otherwise functional fragment or homologue thereof.
    Type: Application
    Filed: April 9, 2003
    Publication date: February 26, 2004
    Inventors: Robyn Heather Wallace, John Charles Mulley, Samuel Frank Berkovic, Louise Anne Harkin, Leanne Michelle Dibbens