Patents by Inventor Rocky J. Barney

Rocky J. Barney has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fluorescent prodrugs
    Patent number: 10814006
    Abstract: The invention provides a drug conjugate comprising: 1) a therapeutic agent that comprises a phosphate, phosphonate, carboxy, or phosphoramidate group, and 2) a fluorescent group linked to the phosphate, phosphonate, carboxy, or phosphoramidate group to form the corresponding ester and salts thereof. The conjugates are useful for therapy and as probes. The invention also provides therapeutic methods for treating diseases with conjugates of the invention as well as methods for determining optimal dosages of a conjugate or a therapeutic agent for a given patient using a conjugate of the invention.
    Type: Grant
    Filed: July 14, 2016
    Date of Patent: October 27, 2020
    Assignees: University of Iowa Research Foundation, University of Connecticut
    Inventors: David F. Wiemer, Rocky J. Barney, Andrew Wiemer
  • FLUORESCENT PRODRUGS
    Publication number: 20180207284
    Abstract: The invention provides a drug conjugate comprising: 1) a therapeutic agent that comprises a phosphate, phosphonate, carboxy, or phosphoramidate group, and 2) a fluorescent group linked to the phosphate, phosphonate, carboxy, or phosphoramidate group to form the corresponding ester and salts thereof. The conjugates are useful for therapy and as probes.
    Type: Application
    Filed: July 14, 2016
    Publication date: July 26, 2018
    Applicants: UNIVERSITY OF IOWA RESEARCH FOUNDATION, UNIVERISTY OF CONNECTICUT
    Inventors: David F. Wiemer, Rocky J. Barney, Andrew Wiemer
  • Prenylated Bisphosphonates as Anti-tuberculosis Agents
    Publication number: 20100240612
    Abstract: The invention provides methods to treat a mycobacterium infection and methods to inhibit mycobacterial polyprenyl pyrophosphate synthesis with a compound of formula I. The invention also provides novel compounds of formula I as well as salts and prodrugs thereof.
    Type: Application
    Filed: March 22, 2010
    Publication date: September 23, 2010
    Applicant: University of Iowa Research Foundation
    Inventors: David F. Wiemer, Rocky J. Barney, Raymond J. Hohl