Patents by Inventor Rocus M. Dekkers

Rocus M. Dekkers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of an antibiotic
    Patent number: 6503727
    Abstract: The invention relates to a process for the preparation of an antibiotic, in particular cefalexin, ampicillin, amoxicillin, cefaclor, cefradin, cefadroxil, cefotaxim and the like, wherein a beta-lactam core is acylated, the antibiotic is recovered from the reaction mixture, the remaining mother liquor is subjected to a hydrolysis reaction in which the antibiotic present in the mother liquor is decomposed into its initial compounds, in particular the beta-lactam core, and the acylation agent is hydrolized. The beta-lactam core can then be recovered virtually quantitatively or recycled to the acylation reaction. This is because it has been found that the solubility of the beta-lactam core is unexpectedly high at relatively high concentrations of acylation agent and antibiotic.
    Type: Grant
    Filed: June 5, 1998
    Date of Patent: January 7, 2003
    Assignee: Gist-Brocades, B.V.
    Inventors: Wilhelmus H. J. Boesten, Wilhelmus J. J. Van Den Tweel, Rocus M. Dekkers
  • Process for preparation of .beta.-lactams at constantly high concentration of reactants
    Patent number: 6048708
    Abstract: An improvement for enzymatically syhnthesizing a .beta.-lactam compound is presented. The improvement comprises catalyzing the acylation of an amino .beta.-lactam with an acylating agent for at least 5 hours with an amidase or acylase, wherein the concentration of each reactant is constantly higher than 70% of the lowest value of the saturated concentration of both reactants.
    Type: Grant
    Filed: February 19, 1997
    Date of Patent: April 11, 2000
    Assignee: Gist-Brocades B.V.
    Inventors: Kim Clausen, Rocus M. Dekkers