Abstract: A device (10) for tempering substances has a metal block arrangement (12) th at least one zone (32) the temperature of which can be set at a determined mean value, as well as at least another zone (32'). The device (10) has a metallic base plate (31) with a receptacle for the substances, and at least one of its outer surfaces can be brought into thermal contact with the metal block arrangement (12). In addition, a pressure generator (49) generates a pressure that deviates from the ambient pressure between at least one outer surface and the metal block arrangement. The device (10) further has a conveyor (33) that selectively conveys the base plate (31) into one of the zones (32, 32') of the metal block arrangement (12) along a conveying path (44). The pressure generator (49) is capable of generating an overpressure or a depression.