Abstract: A method of delivering a therapeutic substance for treatment to a region of the body through vascular isolation and manipulation of fluid flux into and from the region of the body including the steps of: restricting vascular inflow to the region of the body; washing out oncotically active plasma proteins from the region of the body by increasing the outward oncotic pressure gradient from the region of the body; inducing ischemia in the region of the body; controlling the pressure and fluid flow of the main blood vessels to and from the region of the body; providing the therapeutic substance to the region of the body when the fluid flow to the region of the body is controlled.

Abstract: The present disclosure concerns a vascular access device (1) comprising a vascular access tube (2), such as a cannula, having a distal end region (3) terminating in a tip (4) for insertion into a blood vessel (V) of a patient and at least one lumen (5) for infusing a medicament and/or for introducing one or more catheters there-through into the blood vessel (V). The device (1) further comprises a fixation mechanism (10) that is operable to secure or fix the distal end region (3) of the vascular access tube (2) with respect to the patient to inhibit or prevent withdrawal of the tip (4) from the blood vessel (V) and/or to inhibit or prevent overinsertion of the tip (4) into the blood vessel (V).

Abstract: A method of delivering a therapeutic substance for treatment to a region of the body through vascular isolation and manipulation of fluid flux into and from the region of the body including the steps of: restricting vascular inflow to the region of the body; washing out oncotically active plasma proteins from the region of the body by increasing the outward oncotic pressure gradient from the region of the body; inducing ischemia in the region of the body; controlling the pressure and fluid flow of the main blood vessels to and from the region of the body; providing the therapeutic substance to the region of the body when the fluid flow to the region of the body is controlled.

Abstract: A cannulation system for perfusing a patient's circulatory system, includes an inflow cannula having a first end adapted to be connected to said circulatory system and a second end adapted to be connected to a blood pump, an outflow cannula having a first end adapted to be connected to the blood pump and a second end adapted to be connected to said circulatory system at a location downstream of the first end of the inflow cannula. The flow of blood from the pump is in series with the normal blood flow of the circulatory system of the patient and creates a localized region of hypertension.

Abstract: A cannulation system for perfusing a patient's circulatory system, includes an inflow cannula having a first end adapted to be connected to said circulatory system and a second end adapted to be connected to a blood pump, an outflow cannula having a first end adapted to be connected to the blood pump and a second end adapted to be connected to said circulatory system at a location downstream of the first end of the inflow cannula. The flow of blood from the pump is in series with the normal blood flow of the circulatory system of the patient and creates a localized region of hypertension.

Abstract: A cannulation system (10) for perfusing a patient's circulatory system, includes an inflow cannula (14) having a first end adapted to be connected to said circulatory system and a second end adapted to be connected to a blood pump (19), an outflow cannula (23) having a first end adapted to be connected to the blood pump (19) and a second end adapted to be connected to said circulatory system at a location downstream of the first end of the inflow cannula. The flow of blood from the pump (19) is in series with the normal blood flow of the circulatory system of the patient and creates a localized region of hypertension.

Abstract: An endovenous valve transfer stent (10) has an elongated tubular open-work body (12) having a network of longitudinally extending ribs (13) interconnected by laterally extending zigzag struts (14). The struts define a plurality of barbs (15, 17) in opposing longitudinal directions. The body (12) has a first end and a second end, and includes a longitudinal cut through the struts (14) from the first end to the second end. A seam (19) is defined between adjacent cut ends of each strut. The body (12) is adapted, in use, to vary in its diameter to receive a donor valve containing vein segment (20) longitudinally therethrough.

Abstract: A cannulation system (10) for perfusing a patient's circulatory system, includes an inflow cannula (14) having a first end adapted to be connected to said circulatory system and a second end adapted to be connected to a blood pump (19), an outflow cannula (23) having a first end adapted to be connected to the blood pump (19) and a second end adapted to be connected to said circulatory system at a location downstream of the first end of the inflow cannula. The flow of blood from the pump (19) is in series with the normal blood flow of the circulatory system of the patient and creates a localised region of hypertension.

Abstract: Improvements to external stents to render incompetent venous valves competent are disclosed. The device is an inelastic bio-compatible cuff that encircles the venous valve cusps decreasing the internal diameter of the vein wall to allow apposition of the cusps and create competence. The improvements over previous designs include the addition of calibrated known diameters to create competence for different phenotypes. The different diameters are indicated by holes in the body. The buckle attachment allows the body of the device to become conical or inverted to become pyramidal as appropriate. The buckle is wider than prior art designs to allow the device to become elliptical at smaller diameters. The angle of the notches in the device are approximately 150 to allow better overriding at the sapheno-femoral junction which allowing for better competence of the valve.

Abstract: Improvements to external stents to render incompetent venous valves competent are disclosed. The device is an inelastic bio-compatible cuff (1) that encircles the venous valve cusps (15) decreasing the internal diameter of the vein wall (11) to allow apposition of the cusps (15) and create competence. The device may be calibrated to known diameters to create competence for different phenotypes. The different diameters are indicated by holes (2, 3, 4) in the body (1). The buckle attachment (6) allows the body of the device to become conical or inverted to become pyramidal as appropriate. The wide buckle (5) allows the device to become elliptical at smaller diameters. The angle of the notches (10) in the device is approximately 15°, which allows better overriding at the sapheno-femoral junction resulting in better competence of the valve.

Abstract: Improvements to external stents to render incompetent venous valves competent are disclosed. The device is an inelastic bio-compatible cuff (1) that encircles the venous valve cusps (15) decreasing the internal diameter of the vein wall (11) to allow apposition of the cusps (15) and create competence. The improvements over previous designs include the addition of calibrated known diameters to create competence for different phenotypes. The different diameters are indicated by holes (2, 3, 4) in the body (1). The buckle attachment (6) allows the body of the device to become conical or inverted to become pyramidal as appropriate. The buckle (5) is wider than prior art designs to allow the device to become elliptical at smaller diameters. The angle of the notches (10) in the device are approximately 15° to allow better overriding at the sapheno-femoral junction which allowing for better competence of the valve.