Patents by Inventor Rodney L. Balhorn
Rodney L. Balhorn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11285165Abstract: This invention provides novel polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each bind different region son the target molecule. The ligands are joined directly or through a linker thereby forming a polydentate moiety that typically binds the target molecule with high selectivity and avidity.Type: GrantFiled: April 8, 2020Date of Patent: March 29, 2022Assignees: Lawrence Livermore National Security, LLC, The Regents of the University of CaliforniaInventors: Sally J. DeNardo, Gerald L. DeNardo, Rodney L. Balhorn
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Publication number: 20210000843Abstract: This invention provides novel polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each bind different region son the target molecule. The ligands are joined directly or through a linker thereby forming a polydentate moiety that typically binds the target molecule with high selectivity and avidity.Type: ApplicationFiled: April 8, 2020Publication date: January 7, 2021Applicants: LAWRENCE LIVERMORE NATIONAL SECURITY, LLC, THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Sally J. DeNardo, Gerald L. DeNardo, Rodney L. Balhorn
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Patent number: 10874678Abstract: This invention provides novel polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each bind different region son the target molecule. The ligands are joined directly or through a linker thereby forming a polydentate moiety that typically binds the target molecule with high selectivity and avidity.Type: GrantFiled: February 28, 2019Date of Patent: December 29, 2020Assignees: LAWRENCE LIVERMORE NATIONAL SECURITY, LLC, THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Sally J. DeNardo, Gerald L. DeNardo, Rodney L. Balhorn
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Patent number: 10646502Abstract: This invention provides novel polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each bind different region son the target molecule. The ligands are joined directly or through a linker thereby forming a polydentate moiety that typically binds the target molecule with high selectivity and avidity.Type: GrantFiled: September 13, 2017Date of Patent: May 12, 2020Assignee: Lawrence Livermore National SecurityInventors: Sally J. DeNardo, Gerald L. DeNardo, Rodney L. Balhorn
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Publication number: 20190262364Abstract: This invention provides novel polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each bind different region son the target molecule. The ligands are joined directly or through a linker thereby forming a polydentate moiety that typically binds the target molecule with high selectivity and avidity.Type: ApplicationFiled: February 28, 2019Publication date: August 29, 2019Applicants: LAWRENCE LIVERMORE NATIONAL SECURITY, LLC, THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Sally J. DeNardo, Gerald L. DeNardo, Rodney L. Balhorn
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Patent number: 10292992Abstract: This invention provides novel polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each bind different region son the target molecule. The ligands are joined directly or through a linker thereby forming a polydentate moiety that typically binds the target molecule with high selectivity and avidity.Type: GrantFiled: September 13, 2017Date of Patent: May 21, 2019Assignees: Lawrence Livermore National Security, LLC, The Regents of the University of CaliforniaInventors: Sally J. DeNardo, Gerald L. DeNardo, Rodney L. Balhorn
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Patent number: 9884070Abstract: This invention provides novel polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each bind different region son the target molecule. The ligands are joined directly or through a linker thereby forming a polydentate moiety that typically binds the target molecule with high selectivity and avidity.Type: GrantFiled: April 21, 2009Date of Patent: February 6, 2018Assignees: Lawrence Livermore National Security, LLC, The Regents of the University of CaliforniaInventors: Sally J. Denardo, Gerald L. Denardo, Rodney L. Balhorn
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Publication number: 20180008622Abstract: This invention provides novel polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each bind different region son the target molecule. The ligands are joined directly or through a linker thereby forming a polydentate moiety that typically binds the target molecule with high selectivity and avidity.Type: ApplicationFiled: September 13, 2017Publication date: January 11, 2018Applicants: LAWRENCE LIVERMORE NATIONAL SECURITY, LLC, THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Sally J. DeNardo, Gerald L. DeNardo, Rodney L. Balhorn
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Publication number: 20180008621Abstract: This invention provides novel polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each bind different region son the target molecule. The ligands are joined directly or through a linker thereby forming a polydentate moiety that typically binds the target molecule with high selectivity and avidity.Type: ApplicationFiled: September 13, 2017Publication date: January 11, 2018Applicants: LAWRENCE LIVERMORE NATIONAL SECURITY, LLC, THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Sally J. DeNardo, Gerald L. DeNardo, Rodney L. Balhorn
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Publication number: 20130306549Abstract: A nano porous membrane having a uniform array of nanopores etch-formed in a thin film structure (e.g. (100)-oriented single crystal silicon) having a predetermined thickness, by (a) using interferometric lithography to create an etch pattern comprising a plurality array of unit patterns having a predetermined width/diameter, (b) using the etch pattern to etch frustum-shaped cavities or pits in the thin film structure such that the dimension of the frustum floors of the cavities are substantially equal to a desired pore size based on the predetermined thickness of the thin film structure and the predetermined width/diameter of the unit patterns, and (c) removing the frustum floors at a boundary plane of the thin film structure to expose, open, and thereby create the nanopores substantially having the desired pore size.Type: ApplicationFiled: July 23, 2013Publication date: November 21, 2013Inventors: Joseph W. Tringe, Rodney L. Balhorn, Saleem Zaidi
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Patent number: 8512588Abstract: A method of fabricating a nanoporous membrane filter having a uniform array of nanopores etch-formed in a thin film structure (e.g. (100)-oriented single crystal silicon) having a predetermined thickness, by (a) using interferometric lithography to create an etch pattern comprising a plurality array of unit patterns having a predetermined width/diameter, (b) using the etch pattern to etch frustum-shaped cavities or pits in the thin film structure such that the dimension of the frustum floors of the cavities are substantially equal to a desired pore size based on the predetermined thickness of the thin film structure and the predetermined width/diameter of the unit patterns, and (c) removing the frustum floors at a boundary plane of the thin film structure to expose, open, and thereby create the nanopores substantially having the desired pore size.Type: GrantFiled: August 13, 2010Date of Patent: August 20, 2013Assignee: Lawrence Livermore National Security, LLCInventors: Joseph W. Tringe, Rodney L. Balhorn, Saleem Zaidi
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Publication number: 20120037591Abstract: A method of fabricating a nanoporous membrane filter having a uniform array of nanopores etch-formed in a thin film structure (e.g. (100)-oriented single crystal silicon) having a predetermined thickness, by (a) using interferometric lithography to create an etch pattern comprising a plurality array of unit patterns having a predetermined width/diameter, (b) using the etch pattern to etch frustum-shaped cavities or pits in the thin film structure such that the dimension of the frustum floors of the cavities are substantially equal to a desired pore size based on the predetermined thickness of the thin film structure and the predetermined width/diameter of the unit patterns, and (c) removing the frustum floors at a boundary plane of the thin film structure to expose, open, and thereby create the nanopores substantially having the desired pore size.Type: ApplicationFiled: August 13, 2010Publication date: February 16, 2012Inventors: Joseph W. Tringe, Rodney L. Balhorn, Saleem Zaidi
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Publication number: 20110144065Abstract: This invention provides novel polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each bind different region son the target molecule. The ligands are joined directly or through a linker thereby forming a polydentate moiety that typically binds the target molecule with high selectivity and avidity.Type: ApplicationFiled: April 21, 2009Publication date: June 16, 2011Inventors: Sally J. Denardo, Gerald L. Denardo, Rodney L. Balhorn
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Patent number: 7076092Abstract: A method and apparatus with the sensitivity to detect and identify single target molecules through the localization of dual, fluorescently labeled probe molecules. This can be accomplished through specific attachment of the taget to a surface or in a two-dimensional (2D) flowing fluid sheet having approximate dimensions of 0.5 ?m×100 ?m×100 ?m. A device using these methods would have 103–104 greater throughput than previous one-dimensional (1D) micro-stream devices having 1 ?m3 interrogation volumes and would for the first time allow immuno- and DNA assays at ultra-low (femtomolar) concentrations to be performed in short time periods (˜10 minutes). The use of novel labels (such as metal or semiconductor nanoparticles) may be incorporated to further extend the sensitivity possibly into the attomolar range.Type: GrantFiled: June 12, 2002Date of Patent: July 11, 2006Assignee: The United States of America as represented by the United States Department of EnergyInventors: Christopher W. Hollars, Thomas R. Huser, Stephen M. Lane, Rodney L. Balhorn, Olgica Bakajin, Christopher Darrow, Joe H. Satcher, Jr.
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Publication number: 20030186426Abstract: A multichannel flow cell is used to laminarly flow different chemical solutions, including one made up of small polystyrene beads attached to individual DNA molecules, side by side with little mixing. An optical trap is used to pull single DNA molecules via their attached polystyrene beads into each of the different chemical solutions or species sequentially, and the resultant change in the structure of the DNA molecule can be observed using fluorescence microscopy. The technique can be used with molecules other than DNA. Examples of different chemical species include condensing agents such as protamine, enzymes, polymerases, and fluorescent probes and tages.Type: ApplicationFiled: March 14, 2001Publication date: October 2, 2003Applicant: The Regents of the University of CaliforniaInventors: Laurence R. Brewer, Rodney L. Balhorn
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Publication number: 20030114529Abstract: The present invention concerns the generation of hydroxamic acid thrombospondin-peptide analogs that inhibit aggrecanase activity. These analogs are useful in the treatment of diseases characterized by cartilage degradation, such as osteoarthritis, rheumatoid arthritis spondylarthropathies, and septic arthritis. The invention describes a novel small molecule, enzyme inhibitor that binds both the enzyme and its naturally occurring substrate.Type: ApplicationFiled: July 9, 2002Publication date: June 19, 2003Inventors: Michael Tortorella, Jinhai Wang, Rodney L. Balhorn
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Patent number: 6420112Abstract: Microscopic beads or other structures are attached to nucleic acids (DNA) using a terminal transferase. The transferase adds labeled dideoxy nucleotide bases to the ends of linear strands of DNA. The labels, such as the antigens digoxigenin and biotin, bind to the antibody compounds or other appropriate complementary ligands, which are bound to the microscopic beads or other support structures. The method does not require the synthesis of a synthetic oligonucleotide probe. The method can be used to tag or label DNA even when the DNA has an unknown sequence, has blunt ends, or is a very large fragment (e.g., >500 kilobase pairs).Type: GrantFiled: July 21, 1999Date of Patent: July 16, 2002Assignee: The Regents of the University of CaliforniaInventors: Rodney L. Balhorn, Christopher H. Barry
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Publication number: 20010007024Abstract: Microscopic beads or other structures are attached to nucleic acids (DNA) using a terminal transferase. The transferase adds labeled dideoxy nucleotide bases to the ends of linear strands of DNA. The labels, such as the antigens digoxigenin and biotin, bind to the antibody compounds or other appropriate complementary ligands, which are bound to the microscopic beads or other support structures. The method does not require the synthesis of a synthetic oligonucleotide probe. The method can be used to tag or label DNA even when the DNA has an unknown sequence, has blunt ends, or is a very large fragment (e.g., >500 kilobase pairs).Type: ApplicationFiled: July 21, 1999Publication date: July 5, 2001Inventors: RODNEY L. BALHORN, CHRISTOPHER H. BARRY
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Patent number: 5461907Abstract: Instrumentation and techniques to image small objects, such as but not limited to individual human chromosomes, with nanometer resolution, to cut-off identified parts of such objects, to move around and manipulate such cut-off parts on the substrate on which they are being imaged to predetermined locations on the substrate, and to remove the cut-off parts from the substrate. This is accomplished using an atomic force microscope (AFM) and by modification of the conventional cantilever stylus assembly of an AFM, such that plural cantilevers are used with either sharp-tips or knife-edges thereon. In addition, the invention can be utilized for measuring hardness of materials.Type: GrantFiled: March 23, 1993Date of Patent: October 31, 1995Assignee: Regents of the University of CaliforniaInventors: Robert J. Tench, Wigbert J. Siekhaus, Mehdi Balooch, Rodney L. Balhorn, Michael J. Allen
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Patent number: 4331660Abstract: The control of fungus is a serious problem in the hatching of fish. Sodium dichromate, potassium dichromate and chromium trioxide are effective fungicides for the inhibition of fungal growth on fish eggs and young fry during hatching.Type: GrantFiled: March 2, 1981Date of Patent: May 25, 1982Inventor: Rodney L. Balhorn