Abstract: The present invention provides inhibitors of fucosylation during protein expression from mammalian cells. The inhibitors are derived from rhamnose and act by inhibition of GDP-mannose 4,6-dehydratase (GMD). The invention further provides methods of making proteins with reduced level of fucosylation, such as antibodies and antibodies made by the methods of the present invention. Such hypofucosylated or nonfucosylated antibodies may find use, for example, in treatment of human disease in which is it therapeutically eneficial to direct antibody dependent cellular cytotoxicity (ADCC) mediated killing of cells expressing the antibody target on their surface, for example in depletion of Tregs in cancer patients using a hypofucosylated or nonfucosylated anti-CTLA-4 antibody.

Abstract: A system for an engine includes a heat shield system and a crankcase ventilation system. The heat shield system includes at least one heat shield panel. The crankcase ventilation system includes at least one breather, at least one outlet, and at least one conduit extending from the at least one breather to the at least one outlet. A portion of the at least one conduit is coupled to the at least one heat shield panel to directly transfer heat from the heat shield system to the at least one conduit.

Abstract: A valve system may include a valve having a housing with a bore and a valve member positioned within the bore. The valve member may include a valve shaft with a recess. The valve system may also include an actuator having an actuator shaft with an end portion. An adapter may couple the valve shaft and the actuator shaft. The adapter may include a body having a shape corresponding to a shape of the recess of the valve shaft for fitting the adapter within the recess and an aperture extending into the body. The aperture may have a shape corresponding to a shape of the end portion of the actuator shaft for press fitting the adapter onto the actuator shaft. The adapter may fit within the recess and press fit coupled to the actuator shaft.

Abstract: The present disclosure relates to a fluid supply system for a machine. The fluid supply system includes a throttle assembly having a first shaft attached to a valve member and a fluid shutoff assembly. The fluid shutoff assembly includes a second shaft, a locking member having an axis parallel to an axis of the second shaft and comprising a locking arm extending toward the second shaft, a biasing member fixedly attached to the second shaft, a releasing mechanism adjacent to the locking member that rotates the locking member about the longitudinal axis of the locking member, and a coupler comprising a first coupling hub attached to the first shaft and a second coupling hub attached to the second shaft and interfaced with the first coupling hub.

Abstract: A method for ventilating a crankcase of an internal combustion engine using natural gas as a fuel source may include filtering ambient air through an air filter. The method may also include heating the filtered ambient air by a jacket heat exchanger. The method may further include directing the heated ambient air through an inlet of the crankcase to purge blow-by gases including natural gas from the crankcase.

Abstract: The present disclosure relates to a fluid supply system for a machine. The fluid supply system includes a throttle assembly having a first shaft attached to a valve member and a fluid shutoff assembly. The fluid shutoff assembly includes a second shaft, a locking member having an axis parallel to an axis of the second shaft and comprising a locking arm extending toward the second shaft, a biasing member fixedly attached to the second shaft, a releasing mechanism adjacent to the locking member that rotates the locking member about the longitudinal axis of the locking member, and a coupler comprising a first coupling hub attached to the first shaft and a second coupling hub attached to the second shaft and interfaced with the first coupling hub.

Abstract: A valve system may include a valve having a housing with a bore and a valve member positioned within the bore. The valve member may include a valve shaft with a recess. The valve system may also include an actuator having an actuator shaft with an end portion. An adapter may couple the valve shaft and the actuator shaft. The adapter may include a body having a shape corresponding to a shape of the recess of the valve shaft for fitting the adapter within the recess and an aperture extending into the body. The aperture may have a shape corresponding to a shape of the end portion of the actuator shaft for press fitting the adapter onto the actuator shaft. The adapter may fit within the recess and press fit coupled to the actuator shaft.

Abstract: A method for ventilating a crankcase of an internal combustion engine using natural gas as a fuel source may include filtering ambient air through an air filter. The method may also include heating the filtered ambient air by a jacket heat exchanger. The method may further include directing the heated ambient air through an inlet of the crankcase to purge blow-by gases including natural gas from the crankcase.

Abstract: An air shutoff valve for use on an internal combustion engine includes a gate that is moveable between armed and triggered positions by springs when a release pin is retracted and allows a spring loaded retention pin to retract and release the gate, which is also spring loaded, to drop. The release pin is operated by an actuator.

Abstract: An air shutoff valve for use on an internal combustion engine includes a gate that is moveable between armed and triggered positions by springs when a release pin is retracted and allows a spring loaded retention pin to retract and release the gate, which is also spring loaded, to drop. The release pin is operated by an actuator.

Abstract: An air shutoff valve for use on an internal combustion engine includes a gate that is moveable between armed and triggered positions by springs when a retention pin is retracted and allows a spring loaded retention pin to retract and release the gate, which is also spring loaded, to drop. The retention pin is operated by an actuator through a cam mechanism.

Abstract: An internal combustion engine includes a crankcase having first and second pluralities of openings. A oil separation module has at least one inlet housing that communicates with a oil separation filter and is connectable to at least one opening from the first plurality of openings or from the second plurality of openings to define a crankcase vent.

Abstract: A machine system includes a machine, a fluid conduit connected with the machine, and a shutoff valve. The shutoff valve includes a gate swingable through a fluid flow path through the fluid conduit between an open position and a closed position to interrupt a flow of fluid through the fluid conduit to the machine. In an embodiment the machine includes an engine and the fluid conduit includes an air intake conduit such that shutting off the flow of fluid shuts down the engine.

Abstract: A conduit for transferring fluid from one location to another. The conduit includes a tube having an outer surface and an insulation layer surrounding the tube. A heating layer is disposed between the insulation layer and the tube, such that the heating layer is wrapped around the outer surface of the tube. The conduit includes a reinforcement layer sandwiched between the insulation layer and the heating layer.

Abstract: An internal combustion engine includes a crankcase having first and second pluralities of openings. A oil separation module has at least one inlet housing that communicates with a oil separation filter and is connectable to at least one opening from the first plurality of openings or from the second plurality of openings to define a crankcase vent.

Abstract: An internal combustion engine having an oil drain opening connected to an oil drain passage in a cylinder head for simultaneously providing flow of oil to a crankcase and blow-by gases to a crankcase ventilation whereby the geometry of the oil drain opening and oil drain passage are such that the velocity of blow-by gas flow through the oil drain opening is limited.

Abstract: A child restraint system and a method for monitoring installation of the child restraint system are provided. The child restraint system includes a child seat configured to receive a child occupant. The child restraint system further includes a first sensor coupled to the child seat. The first sensor is configured to output a first signal indicative of positional angle of the child seat relative to a first axis. The child restraint system further includes a controller coupled to the child seat configured to receive the first signal and to calculate a first angle value based on the first signal. The controller is further configured to induce a first device disposed on the child seat to indicate when the first angle value is not within a predetermined angular range from the first axis.

Abstract: A child restraint system and a method for monitoring installation of the child restraint system are provided. The child restraint system includes a child seat configured to receive a child occupant. The child seat has at least a first seat belt guide member configured to engage a vehicle seat belt webbing for securing the child seat to a vehicle seat. The child restraint system further includes a first sensor coupled to the first seat belt guide member. The first sensor is configured to output a first signal indicative of an amount of tension being applied to the vehicle seat belt webbing. The child restraint system further includes a controller coupled to the child seat configured to receive the first signal and to compute a first tension value based on the first signal. The controller further is configured to induce a first device disposed on the child seat to indicate when the first tension value is less than a predetermined tension value.

Abstract: A child restraint system that is adapted to be mounted within a vehicle is provided. The child restraint system includes a child seat configured to receive a child occupant. The child seat has a frame, at least first and second docking stations, and a child seat monitoring device. The first and second docking stations are disposed at first and second locations on the frame. Both of the first and second docking stations are configured to receive and hold the child seat monitoring device therein.

Abstract: The invention relates to a set of components configured to form an animal processing station, the set of components including at least two side panels which, when assembled, define two opposite sides of the animal processing station, and a base panel, wherein the base panel is configured to removably interlock, either directly or indirectly, with at least two diagonally opposite ends of the opposite side panels and wherein at least one of the panels is formed from a reinforced moulded material.