Abstract: A catheter treatment apparatus comprises an elongate tubular member and an expandable support. The expandable support comprises a radioactive substance to treat cancerous tissue and is configured to expand from a narrow profile for insertion to a wide profile to engage and treat tissue remaining after resection. The expandable support can be sized to fit within a volume of removed tissue to place the radioactive substance in proximity to the capsule and remaining tissue, to spare the capsule and proximate nerves and vessels to treat tissue in proximity to the capsule. The elongate tubular member may comprise a channel such as a lumen to pass a bodily fluid such as urine when the expandable support engages the tissue to treat the patient for a plurality of days. The treatment apparatus can be used to resect and diagnose tissue concurrently. Based on the diagnosis, targeted segmental treatment may be given.

Abstract: A catheter treatment apparatus comprises an elongate tubular member and an expandable support. The expandable support comprises a radioactive substance to treat cancerous tissue and is configured to expand from a narrow profile for insertion to a wide profile to engage and treat tissue remaining after resection. The expandable support can be sized to fit within a volume of removed tissue to place the radioactive substance in proximity to the capsule and remaining tissue, to spare the capsule and proximate nerves and vessels to treat tissue in proximity to the capsule. The elongate tubular member may comprise a channel such as a lumen to pass a bodily fluid such as urine when the expandable support engages the tissue to treat the patient for a plurality of days. The treatment apparatus can be used to resect and diagnose tissue concurrently. Based on the diagnosis, targeted segmental treatment may be given.

Abstract: The present invention is directed to a wearable system wherein elements of the system, including various sensors adapted to detect biometric and other data and/or to deliver drugs, are positioned proximal to, on or in the ear canal of a person. In embodiments of the invention, elements of the system, including drug delivery devices, are positioned on or in the ear canal for extended periods of time. For example, an element of the system may be positioned on the tympanic membrane of a user and left there overnight, for multiple days, months, or years. Because of the position and longevity of the system elements in the ear canal, the present invention has many advantages over prior wearable biometric and drug delivery devices.

Abstract: The present invention is directed to a wearable system wherein elements of the system, including various sensors adapted to detect biometric and other data and/or to deliver drugs, are positioned proximal to, on the ear or in the ear canal of a person. In embodiments of the invention, elements of the system are positioned on the ear or in the ear canal for extended periods of time. For example, an element of the system may be positioned on the tympanic membrane of a user and left there overnight, for multiple days, months, or years. Because of the position and longevity of the system elements in the ear canal, the present invention has many advantages over prior wearable biometric and drug delivery devices.

Abstract: The present invention provides systems, methods, devices and kits for assessing the level of pulmonary disease in individual lung compartments. A lung compartment comprises a subportion of a lung, such as a lobe, a segment or a subsegment, for example. By measuring individual lung compartments, the level of disease of the pulmonary system may be more precisely defined by determining values of disease parameters reflective of individual subportions or compartments of a lung. Likewise, compartments may be separately imaged to provide further measurement information. Once individual compartments are characterized, they may be compared and ranked based on a number of variables reflecting, for example, level of disease or need for treatment. Such comparison may be aided by simultaneous display of such variables or images on a visual display. Further, the same tests may be performed on the lung as a whole or on both lungs and to determine the affect of the diseased lung compartments on the overall lung performance.

Abstract: Prostate treatment using fluid stream to resect prostate tissue, thereby relieving symptoms of conditions such as BPH, prostatitis, and prostatic carcinoma. A device having a fluid delivery element is positioned within a lumen of the urethra within the prostate. A fluid stream is directed outwardly from the fluid delivery element toward a wall of the urethral lumen. The fluid delivery element is moved to scan the fluid stream over the wall to remove a volume of tissue surrounding the lumen. The fluid may be combined with therapeutically active substances or with substances that increase resection efficiency. Fluid force may be adjusted to provide selective tissue resection such that soft tissue is removed while harder tissue is left undamaged. In order to gain a working space within the urethra, another fluid may be introduced to insufflate the urethra in the region of treatment.

Abstract: The present invention provides systems, methods, devices and kits for assessing the level of pulmonary disease in individual lung compartments. A lung compartment comprises a subportion of a lung, such as a lobe, a segment or a subsegment, for example. By measuring individual lung compartments, the level of disease of the pulmonary system may be more precisely defined by determining values of disease parameters reflective of individual subportions or compartments of a lung. Likewise, compartments may be separately imaged to provide further measurement information. Once individual compartments are characterized, they may be compared and ranked based on a number of variables reflecting, for example, level of disease or need for treatment. Such comparison may be aided by simultaneous display of such variables or images on a visual display. Further, the same tests may be performed on the lung as a whole or on both lungs and to determine the affect of the diseased lung compartments on the overall lung performance.

Abstract: An ear module, which can be selectively worn on either left or right ear, comprises an interior lobe, adapted to fit within the concha, comprising a speaker and a compressive member/cover assembly. The compressive member/cover assembly is positionable, typically rotatable, relative to the remainder of the inner lobe between left and right ear orientations to permit the ear module to be worn on either the left or the right ear. A method for improving the quality of sound emanating from an ear module includes selecting the sound bore within the ear module to help improve the frequency response of the ear module so that the ear module has a resonant peak near 2.7 kHz and a maximum 20 dB decrease in high frequency response as measured at 5 kHz from the average frequency response as measured at 500 Hz, 800 Hz, and 1600 Hz.

Abstract: A method of generating a personalized sound system hearing profile for a user. The method begins by selecting an initial profile, based on selected factors of user input. In an embodiment, the initial profile is selected based on demographic factors. Then the system identifies one or more alternate profiles, each having a selected relationship with the initial profile. The relationship between alternate profiles and the initial profile can be based on gain as a function of frequency, one alternate profile having a higher sensitivity at given frequencies and the other a lower sensitivity. The next step links at least one audio sample with the initial and alternate profiles and then plays the selected samples for the user. The system then receives identification of the preferred sample from the user; and selects a final profile based on the user's preference. An embodiment offers multiple sound samples in different modes, resulting in the selection of multiple final profiles for the different modes.

Abstract: An ear module with an interior lobe (200) housing a speaker (58) and adapted to fit within the Concha (103) of the outer ear, and an exterior lobe (300) housing data processing resources, includes a compressive member (202) coupled to the interior lobe (200) and providing a holding force between the anti-helix (101) and the forward wall (108) of the ear canal (102) near the tragus (104). The interior lobe (200) extends into the exterior opening (110) of the ear canal (102), and includes a forward surface (210) adapted to fit against the forward wall (108) of the ear canal (102), and a rear surface (211) facing the anti-helix (101). The width of the extension (201) (in a dimension orthogonal to the forward surface (210) of the extension (201)) between the forward surface (210) and the rear surface (211) from at least the opening of the ear canal (102) to the tip (203) of the extension (201) is substantially less than the width of the ear canal (102), leaving an open air passage (250).

Abstract: Apparatus for directly stimulating a tympanic membrane or other acoustic member comprising a support with a plurality of activatable elements. The support can be mounted on the tympanic membrane and the activatable elements are distributed on the support to provide a distributed vibration to the tympanic membrane.

Abstract: Lung volume reduction is performed in a minimally invasive manner by isolating a lung tissue segment, optionally reducing gas flow obstructions within the segment, and aspirating the segment to cause the segment to at least partially collapse. Further optionally, external pressure may be applied on the segment to assist in complete collapse. Reduction of gas flow obstructions may be achieved in a variety of ways, including over inflation of the lung, introduction of mucolytic or dilation agents, application of vibrational energy, induction of absorption atelectasis, or the like. Optionally, diagnostic procedures on the isolated lung segment may be performed, typically using the same isolation/access catheter.

Abstract: An ear module, which can be selectively worn on either left or right ear, comprises an interior lobe, adapted to fit within the concha, comprising a speaker and a compressive member/cover assembly. The compressive member/cover assembly is positionable, typically rotatable, relative to the remainder of the inner lobe between left and right ear orientations to permit the ear module to be worn on either the left or the right ear. A method for improving the quality of sound emanating from an ear module includes selecting the sound bore within the ear module to help improve the frequency response of the ear module so that the ear module has a resonant peak near 2.7 kHz and a maximum 20 dB decrease in high frequency response as measured at 5 kHz from the average frequency response as measured at 500 Hz, 800 Hz, and 1600 Hz.

Abstract: An ear module with an interior lobe (200) housing a speaker (58) and adapted to fit within the Concha (103) of the outer ear, and an exterior lobe (300) housing data processing resources, includes a compressive member (202) coupled to the interior lobe (200) and providing a holding force between the anti-helix (101) and the forward wall (108) of the car canal (102) near the tragus (104). The interior lobe (200) extends into the exterior opening (1 10) of the ear canal (102), and includes a forward surface (210) adapted to fit against the forward wall (108) of the ear canal (102), and a rear surface (211) facing the anti-helix (101). The width of the extension (201) (in a dimension orthogonal to the forward surface (210) of the extension (201)) between the forward surface (210) and the rear surface (211) from at least the opening of the ear canal (102) to the tip (203) of the extension (201) is substantially less than the width of the ear canal (102), leaving an open air passage (250).

Abstract: The present invention provides systems, methods, devices and kits for assessing the level of pulmonary disease in individual lung compartments. A lung compartment comprises a subportion of a lung, such as a lobe, a segment or a subsegment, for example. By measuring individual lung compartments, the level of disease of the pulmonary system may be more precisely defined by determining values of disease parameters reflective of individual subportions or compartments of a lung. Likewise, compartments may be separately imaged to provide further measurement information. Once individual compartments are characterized, they may be compared and ranked based on a number of variables reflecting, for example, level of disease or need for treatment. Such comparison may be aided by simultaneous display of such variables or images on a visual display. Further, the same tests may be performed on the lung as a whole or on both lungs and to determine the affect of the diseased lung compartments on the overall lung performance.

Abstract: A method of generating a personalized sound system hearing profile for a user. The method begins by selecting an initial profile, based on selected factors of user input. In an embodiment, the initial profile is selected based on demographic factors. Then the system identifies one or more alternate profiles, each having a selected relationship with the initial profile. The relationship between alternate profiles and the initial profile can be based on gain as a function of frequency, one alternate profile having a higher sensitivity at given frequencies and the other a lower sensitivity. The next step links at least one audio sample with the initial and alternate profiles and then plays the selected samples for the user. The system then receives identification of the preferred sample from the user; and selects a final profile based on the user's preference. An embodiment offers multiple sound samples in different modes, resulting in the selection of multiple final profiles for the different modes.

Abstract: Minimally invasive systems and methods are provided for diagnosing conditions in target lung compartments. Using catheters capable of isolating the target lung compartments and measuring one or more of collateral ventilation, pressure, flow rate, and volume, conditions such as hyperinflation, compliance, gas exchange including oxygen uptake, directionality of collateral channels, blood flow, and blood flow per unit lung volume may be assessed.

Abstract: Apparatus for directly stimulating a tympanic membrane or other acoustic member comprising a support with a plurality of activatable elements. The support can be mounted on the tympanic membrane and the activatable elements are distributed on the support to provide a distributed vibration to the tympanic membrane.

Abstract: Lung volume reduction is performed in a minimally invasive manner by isolating a lung tissue segment, optionally reducing gas flow obstructions within the segment, and aspirating the segment to cause the segment to at least partially collapse. Further optionally, external pressure may be applied on the segment to assist in complete collapse. Reduction of gas flow obstructions may be achieved in a variety of ways, including over inflation of the lung, introduction of mucolytic or dilation agents, application of vibrational energy, induction of absorption atelectasis, or the like. Optionally, diagnostic procedures on the isolated lung segment may be performed, typically using the same isolation/access catheter.