Abstract: Presented herein are methods for making, isolating, and purifying N-acetylcysteine amide, (2R,2R?)-3,3?-disulfanediyl bis(2-acetamidopropanamide, diNACA), intermediates and derivatives thereof comprising: alternatively contacting cystine with methanol and a chlorinating reagent to form an organic solution containing L-cystine dimethylester dihydrochloride; combining dried or undried L-cystine dimethylester dihydrochloride with a triethylamine, an acetic anhydride, and an acetonitrile to form a di-N-acetylcystine dimethylester; mixing dried di-N-acetylcystine dimethylester with ammonium hydroxide to form a di-N-acetylcystine amide (diNACA); and separating dried di-N-acetylcystine dimethylester into N-acetylcysteine amide with dithiothreitol, triethylamine, and an alcohol.

Abstract: The present invention includes methods for making and isolating N-acetylcysteine amide, (2R,2R?)-3,3?-disulfanediyl bis(2-acetamidopropanamide, diNACA), intermediates and derivatives thereof comprising: contacting cystine with an alcohol and a chlorinating reagent to form an organic solution containing L-cystine dimethylester dihydrochloride; combining dried or undried L-cystine dimethylester dihydrochloride with a triethylamine, an acetic anhydride, and an acetonitrile to form a di-N-acetylcystine dimethylester; mixing dried di-N-acetylcystine dimethylester with ammonium hydroxide to form a di-N-acetylcystine amide (diNACA); and separating dried di-N-acetylcystine dimethylester into N-acetylcysteine amide with dithiothreitol, triethylamine and an alcohol.

Abstract: The present invention includes methods for making and isolating N-acetylcysteine amide, (2R,2R?)-3,3?-disulfanediyl bis(2-acetamidopropanamide, diNACA), intermediates and derivatives thereof comprising: contacting cystine with an alcohol and a chlorinating reagent to form an organic solution containing L-cystine dimethylester dihydrochloride; combining dried or undried L-cystine dimethylester dihydrochloride with a triethylamine, an acetic anhydride, and an acetonitrile to form a di-N-acetylcystine dimethylester; mixing dried di-N-acetylcystine dimethylester with ammonium hydroxide to form a di-N-acetylcystine amide (diNACA); and separating dried di-N-acetylcystine dimethylester into N-acetylcysteine amide with dithiothreitol, triethylamine and an alcohol.

Abstract: The present invention includes methods for making and isolating N-acetylcysteine amide, (2R,2R?)-3,3?-disulfanediyl bis(2-acetamidopropanamide, diNACA), intermediates and derivatives thereof comprising: contacting cystine with an alcohol and a chlorinating reagent to form an organic solution containing L-cystine dimethylester dihydrochloride; combining dried or undried L-cystine dimethylester dihydrochloride with a triethylamine, an acetic anhydride, and an acetonitrile to form a di-N-acetylcystine dimethylester; mixing dried di-N-acetylcystine dimethylester with ammonium hydroxide to form a di-N-acetylcystine amide (diNACA); and separating dried di-N-acetylcystine dimethylester into N-acetylcysteine amide with dithiothreitol, triethylamine and an alcohol.

Abstract: The present invention includes methods for making and isolating N-acetylcysteine amide, (2R,2R?)-3,3?-disulfanediyl bis(2-acetamidopropanamide, diNACA), intermediates and derivatives thereof comprising: contacting cystine with an alcohol and a chlorinating reagent to form an organic solution containing L-cystine dimethylester dihydrochloride; combining dried or undried L-cystine dimethylester dihydrochloride with a triethylamine, an acetic anhydride, and an acetonitrile to form a di-N-acetylcystine dimethylester; mixing dried di-N-acetylcystine dimethylester with ammonium hydroxide to form a di-N-acetylcystine amide (diNACA); and separating dried di-N-acetylcystine dimethylester into N-acetylcysteine amide with dithiothreitol, triethylamine and an alcohol.

Abstract: The present invention includes methods for making and isolating N-acetylcysteine amide, intermediates and derivatives thereof comprising: contacting cystine with an alcohol and a chlorinating reagent to form an organic solution containing L-cystine dimethylester dihydrochloride; combining dried or undried L-cystine dimethylester dihydrochloride with a triethylamine, an acetic anhydride, and an acetonitrile to form a di-N-acetylcystine dimethylester; mixing dried di-N-acetylcystine dimethylester with ammonium hydroxide to form a di-N-acetylcystine amide; and separating dried di-N-acetylcystine dimethylester into N-acetylcysteine amide with dithiothreitol, triethylamine and an alcohol.

Abstract: The present invention includes methods for making and isolating N-acetylcysteine amide, intermediates and derivatives thereof comprising: contacting cystine with an alcohol and a chlorinating reagent to form an organic solution containing L-cystine dimethylester dihydrochloride; combining dried or undried L-cystine dimethylester dihydrochloride with a triethylamine, an acetic anhydride, and an acetonitrile to form a di-N-acetylcystine dimethylester; mixing dried di-N-acetylcystine dimethylester with ammonium hydroxide to form a di-N-acetylcystine amide; and separating dried di-N-acetylcystine dimethylester into N-acetylcysteine amide with dithiothreitol, triethylamine and an alcohol.

Abstract: A method and apparatus for providing an efficient optical access network. In a preferred embodiment, a single light source is used to generate light in a network node, such as an OLT (optical line terminal). The generated light is then distributed using an optical splitter to a plurality of outputs, each associated with an ONU. The distributed light intended for a particular ONU (optical network unit) is modulated, for example by an EOM (electro-optical modulator), with a signal carrying communications for the intended ONU. The OLT includes a bank of EOMs or other kind of optical modulators, such as EAMs for serving a plurality of ONUs. The OLT may also include a second light source for generating light that is propagated to one or more of the ONUs for their use in forming upstream transmissions.

Abstract: The polarization of the lightwave at the input to a heterodyne receiver can be determined by measurements of the amplitude of electrical signals without the need for phase measurements. This allows more accurate measurements of the polarization in the presence of noise and allows a determination of the degree of polarization of the lightwave.

Abstract: An optical heterodyne detection system includes a tunable optical pre-selector that is adjusted to track the frequency of a swept local oscillator signal. The tunable optical pre-selector is adjusted in response to a measure of the frequency of the swept local oscillator signal and in response to a measure of a portion of the swept local oscillator signal after the portion of the swept local oscillator signal optically interacts with the pre-selector. Additionally, the pre-selector is dithered such that a dither is imparted on the portion of the swept local oscillator signal that interacts with the optical pre-selector.

Abstract: An optical network (10) comprising a plurality of optical network units (12), an optical line terminal unit, and a first optical combiner unit (20), wherein the optical network units (12) are optically connected to the first optical combiner unit (20) via respective optical connections in a manner such that optical transmissions from the optical network units (12) are combined onto one optical line connection to the optical line terminal unit, a redirection unit (24) for redirecting a portion of a transmission signal on the optical line connection towards the first combiner unit (20) each optical network unit (12) comprising an optical transmitter unit (14) for transmitting an optical signal to the optical line terminal unit, and a CSMA/CD unit (16) arranged, in use, to tap off at least a portion of the redirected portion of the transmission signal from the optical connection between the optical network unit (12) and the first combiner unit (20), wherein the CSMA/CD unit (16) is further arranged to control th

Abstract: An optical drop structure comprising a multi-port optical circulator (MOC), a first reflection filter unit optically connected in series between a first port and a second port of the MOC, a second reflection filter unit optically connected in series between a third port and a fourth port of the MOC, and the optical drop structure is arranged, in use, in a manner such that, a first optical signal entering through a fifth port of the MOC is subjected to the first reflection filter unit and exits at a sixth port of the MOC and a reflected portion of the first optical signal exits at a seventh port of the MOC, and a second optical signal entering through the sixth port of the MOC is subjected to the second reflection filter unit and exits at the fifth port of the MOC and a reflected portion of the second optical signal exits at an eights port of the MOC.