Patents by Inventor Rodolfo A. Martinez

Rodolfo A. Martinez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20110010878
    Abstract: An apparatus for remediating hydrazine from hydrazine contaminated surfaces. Pads or wipes can be utilized to remediate hydrazine spills. In its operational form, the dicarbonyl compound may be present on or in the absorbent material in a dry form or an aqueous solution. The apparatus includes a wipe comprising an absorbent medium pre-treated with a dicarbonyl compound, wherein the surface contaminated with hydrazine reacts with the dicarbonyl compound of the wipe to neutralize and convert the hydrazine into a stable organic compound, thereby decontaminating the surface. The wipe itself may include a porous surface cover surrounding an inert absorbent interior component of the wipe that in turn surrounds an absorbent interior core comprising a dicarbonyl compound that reacts with the hydrazine in order to neutralize the hydrazine on the surface. The absorbent medium generally comprises a porous outer fabric surface covering that draws the hydrazine on the surface to the wipe.
    Type: Application
    Filed: July 19, 2010
    Publication date: January 20, 2011
    Inventors: Rodolfo A. Martinez, Merritt C. Helvenston, Jose C' De Baca, John R. Juarez
  • Publication number: 20100317886
    Abstract: All labeled carbons are derived ultimately from CO, as carbon-13 is separated from its lighter isotope by cyrogenic distillation of carbon monoxide (CO). Creation of stereospecific and site-specific compounds used for starting materials will address growing demands for labeled compounds, including isotopically-labeled functionalized dienes. Functionalized diene compounds can be used as precursors for the production of isotopically labeled pharmaceuticals, biomolecules, and natural products.
    Type: Application
    Filed: June 11, 2010
    Publication date: December 16, 2010
    Inventor: Rodolfo A. Martinez
  • Patent number: 7851647
    Abstract: Alkoxy[13C]methyl phenyl sulfone is a precursor to the production of Lithium (E)-?-Alkoxy[1,2,3-13C3]acrylate and thence Alkoxy (E)-?-Alkoxy[1,2,3-13C3]acrylate. Alkoxy (E)-?-Alkoxy[1,2,3-13C3]acrylate can then serve as a precursor for the production of a number of other isotopically labeled compounds. Similar chemistry using Alkoxy[14C]methyl phenyl sulfone as the precursor can yield 14C labeled compounds. High purity precursors ensure that the new compounds are also highly pure.
    Type: Grant
    Filed: April 4, 2008
    Date of Patent: December 14, 2010
    Inventor: Rodolfo A. Martinez
  • Publication number: 20100069675
    Abstract: The present invention is directed to the labeled compounds, wherein C* is each either 13C and 12C where at least one C* is 13C, each hydrogen of the methylene group is hydrogen or deuterium, the methyl group includes either zero or three deuterium atoms, Q is sulfide, sulfinyl, or sulfone, Z is an aryl group such as 1-naphthyl, substituted 1-naphthyl, 2-naphthyl, substituted 2-naphthyl, or a phenyl group wherein R1, R2, R3, R4 and R5 are each independently either hydrogen, a C1-C4 lower alkyl, a halogen, and an amino group such as NH2, NHR and NRR? where R and R? are each independently either a C1-C4 lower alkyl, a phenyl, and an alkoxy group, and the methyl group can include either zero or three deuterium atoms.
    Type: Application
    Filed: September 1, 2009
    Publication date: March 18, 2010
    Applicant: Los Alamos National Security, LLC
    Inventors: Rodolfo A. Martinez, Clifford J. Unkefer, Marc A. Alvarez
  • Patent number: 7662993
    Abstract: The present invention is directed to labeled compounds of the formulae wherein Q is selected from the group consisting of —S(?O)—, and —S(?O)2—, Z is selected from the group consisting of 1-naphthyl, substituted 1-naphthyl, 2-naphthyl, substituted 2-naphthyl, and phenyl groups with the structure wherein R1, R2, R3, R4 and R5 are each independently selected from the group consisting of hydrogen, a C1-C4 lower alkyl, a halogen, and an amino group selected from the group consisting of NH2, NHR and NRR? where R and R? are each independently selected from the group consisting of a C1-C4 lower alkyl, an aryl, and an alkoxy group, and X is selected from the group consisting of hydrogen, a C1-C4 lower alkyl group, and a fully-deuterated C1-C4 lower alkyl group.
    Type: Grant
    Filed: November 2, 2006
    Date of Patent: February 16, 2010
    Assignee: Los Alamos National Security, LLC
    Inventors: Marc A. Alvarez, Rodolfo A. Martinez, Clifford J. Unkefer
  • Publication number: 20090259064
    Abstract: High purity isotopically labeled phosphonic acid esters can be obtained from isotopically enriched Chloro[13C]methyl phenyl sulfide The labeled phosphonic acid esters can then be used as precursors for the one step production of labeled vinyl sulfides, labeled vinyl sulfoxides, and labeled vinyl sulfones. The labeled phosphonic acid esters can also be reacted with a variety of aldehydes to produce extended vinyl systems that are isotopically labeled.
    Type: Application
    Filed: April 9, 2009
    Publication date: October 15, 2009
    Inventor: Rodolfo A. Martinez
  • Patent number: 7582801
    Abstract: The present invention is directed to labeled compounds, of the formulae wherein C* is each independently selected from the group consisting of 13C and 12C with the proviso that at least one C* is 13C, each hydrogen of the methylene group can independently be either hydrogen or deuterium, the methyl group includes either zero or three deuterium atoms, Q is from the group of sulfide, sulfinyl, and sulfone, Z is an aryl group from the group of 1-naphthyl, substituted 1-naphthyl, 2-naphthyl, substituted 2-naphthyl, and phenyl groups with the structure wherein R1, R2, R3, R4 and R5 are each independently from the group of hydrogen, a C1-C4 lower alkyl, a halogen, and an amino group from the group of NH2, NHR and NRR? where R and R? are each independently from the group of a C1-C4 lower alkyl, a phenyl, and an alkoxy group, and the methyl group can include either zero or three deuterium atoms.
    Type: Grant
    Filed: February 7, 2005
    Date of Patent: September 1, 2009
    Assignee: Los Alamos National Security, LLC
    Inventors: Rodolfo A. Martinez, Clifford J. Unkefer, Marc A. Alvarez
  • Publication number: 20090030232
    Abstract: The present invention is directed to the labeled compounds, wherein C* is each either 13C and 12C where at least one C* is 13C, each hydrogen of the methylene group is hydrogen or deuterium, the methyl group includes either zero or three deuterium atoms, Q is sulfide, sulfinyl, or sulfone, Z is an aryl group such as 1-naphthyl, substituted 1-naphthyl, 2-naphthyl, substituted 2-naphthyl, or a phenyl group wherein R1, R2, R3, R4 and R5 are each independently either hydrogen, a C1-C4 lower alkyl, a halogen, and an amino group such as NH2, NHR and NRR? where R and R? are each independently either a C1-C4 lower alkyl, a phenyl, and an alkoxy group, and the methyl group can include either zero or three deuterium atoms.
    Type: Application
    Filed: July 22, 2008
    Publication date: January 29, 2009
    Inventors: Rodolfo A. Martinez, Clifford J. Unkefer, Marc A. Alvarez
  • Publication number: 20080269527
    Abstract: The use of vinyl sulfides, sulfoxides and sulfones in synthetic chemistry for the production of a wide variety of materials is well known. For example, phenyl vinyl sulfides, sulfoxides and sulfones have been used for the synthesis of important heterocycles, in combinatorial chemistry and as Diels-Alder adducts. Although these compounds have been used extensively for a variety of applications, the isotopically labeled versions have not been reported. A simple route for the isotopically labeled production of these important building blocks has been developed.
    Type: Application
    Filed: February 22, 2008
    Publication date: October 30, 2008
    Inventor: Rodolfo A. Martinez
  • Publication number: 20080255384
    Abstract: Alkoxy[13C]methyl phenyl sulfone is a precursor to the production of Lithium (E)-?-Alkoxy[1,2,3-13C3]acrylate and thence Alkoxy (E)-?-Alkoxy[1,2,3-13C3]acrylate. Alkoxy (E)-?-Alkoxy[1,2,3-13C3]acrylate can then serve as a precursor for the production of a number of other isotopically labeled compounds. Similar chemistry using Alkoxy[14C]methyl phenyl sulfone as the precursor can yield 14C labeled compounds. High purity precursors ensure that the new compounds are also highly pure.
    Type: Application
    Filed: April 4, 2008
    Publication date: October 16, 2008
    Inventor: Rodolfo A. Martinez
  • Publication number: 20080255370
    Abstract: The chemistry of [13C]methyl phenyl sulfide is exploited to produce new isotopically labeled precursors that allow for the facile assembly of a wide range of labeled molecules from simple and relatively inexpensive starting materials. These compounds are applicable to a variety of research areas such as quantum computing, metabolism and materials science.
    Type: Application
    Filed: April 4, 2008
    Publication date: October 16, 2008
    Inventor: Rodolfo A. Martinez
  • Patent number: 7321070
    Abstract: The present invention is directed to asymmetric chiral labeled glycerols including at least one chiral atom, from one to two 13C atoms and from zero to four deuterium atoms bonded directly to a carbon atom, e.g., (2S) [1,2-13C2]glycerol and (2R) [1,2-13C2]glycerol, and to the use of such chiral glycerols in the preparation of labeled amino acids.
    Type: Grant
    Filed: July 30, 2003
    Date of Patent: January 22, 2008
    Assignee: Los Alamos National Security, LLC
    Inventors: Rodolfo A. Martinez, Clifford J. Unkefer, Marc A. Alvarez
  • Patent number: 7321049
    Abstract: The present invention is directed to labeled compounds of the formulae wherein Q is selected from the group consisting of —S—, —S(?O)—, and —S(?O)2—, Z is selected from the group consisting of 1-naphthyl, substituted 1-naphthyl, 2-naphthyl, substituted 2-naphthyl, and phenyl groups with the structure wherein R1, R2, R3, R4 and R5 are each independently selected from the group consisting of hydrogen, a C1-C4 lower alkyl, a halogen, and an amino group selected from the group consisting of NH2, NHR and NRR? where R and R? are each independently selected from the group consisting of a C1-C4 lower alkyl, an aryl, and an alkoxy group, and X is selected from the group consisting of hydrogen, a C1-C4 lower alkyl group, and a fully-deuterated C1-C4 lower alkyl group. The present invention is also directed to a process of preparing labeled compounds, e.g.
    Type: Grant
    Filed: November 4, 2005
    Date of Patent: January 22, 2008
    Assignee: Los Alamos National Security, LLC
    Inventors: Marc A. Alvarez, Rodolfo A. Martinez, Clifford J. Unkefer
  • Publication number: 20070191635
    Abstract: The present invention is directed to labeled compounds of the formulae wherein Q is selected from the group consisting of —S—, —S(?O)—, and —S(?O)2—, Z is selected from the group consisting of 1-naphthyl, substituted 1-naphthyl, 2-naphthyl, substituted 2-naphthyl, and phenyl groups with the structure wherein R1, R2, R3, R4 and R5 are each independently selected from the group consisting of hydrogen, a C1-C4 lower alkyl, a halogen, and an amino group selected from the group consisting of NH2, NHR and NRR? where R and R? are each independently selected from the group consisting of a C1-C4 lower alkyl, an aryl, and an alkoxy group, and X is selected from the group consisting of hydrogen, a C1-C4 lower alkyl group, and a fully-deuterated C1-C4 lower alkyl group. The present invention is also directed to a process of preparing labeled compounds, e.g.
    Type: Application
    Filed: November 2, 2006
    Publication date: August 16, 2007
    Inventors: Marc Alvarez, Rodolfo Martinez, Clifford Unkefer
  • Publication number: 20070105719
    Abstract: The present invention describes a composition including a mixture of L- and D-pyroglutamate stereoisomers in a ratio of L to D of from about 80:20 to about 97:3, and, a carrier medium for application of the L- and D-pyroglutamate stereoisomers to a target plant. The composition can also be used as a germination medium and may be incorporated into a seed coat for assisting in germination. The present invention further describes a method of increasing the agronomic performance of a target plant by treating a target plant with a composition including a mixture of L- and D-pyroglutamate stereoisomers in a ratio of L to D of from about 80:20 to about 97:3 and a carrier medium for said L- and D-pyroglutamate stereoisomers.
    Type: Application
    Filed: November 7, 2005
    Publication date: May 10, 2007
    Inventors: Pat Unkefer, Rodolfo Martinez, Thomas Knight
  • Publication number: 20070106085
    Abstract: The present invention is directed to labeled compounds of the formulae wherein Q is selected from the group consisting of —S—, —S(?O)—, and —S(?O)2—, Z is selected from the group consisting of 1-naphthyl, substituted 1-naphthyl, 2-naphthyl, substituted 2-naphthyl, and phenyl groups with the structure wherein R1, R2, R3, R4 and R5 are each independently selected from the group consisting of hydrogen, a C1-C4 lower alkyl, a halogen, and an amino group selected from the group consisting of NH2, NHR and NRR? where R and R? are each independently selected from the group consisting of a C1-C4 lower alkyl, an aryl, and an alkoxy group, and X is selected from the group consisting of hydrogen, a C1-C4 lower alkyl group, and a fully-deuterated C1-C4 lower alkyl group. The present invention is also directed to a process of preparing labeled compounds, e.g.
    Type: Application
    Filed: November 4, 2005
    Publication date: May 10, 2007
    Inventors: Marc Alvarez, Rodolfo Martinez, Clifford Unkefer
  • Publication number: 20070004929
    Abstract: The present invention is directed to labeled compounds of the formula Ar-Z1-Q-Z2 where Ar is an aryl group is selected from the group consisting of 1-naphthyl, substituted 1-naphthyl, 2-naphthyl, substituted 2-naphthyl, and phenyl groups with the structure wherein R1, R2, R3, R4 and R5 are each independently selected from the group consisting of hydrogen, a C1-C4 lower alkyl, a halogen, a phenyl, an alkoxy group and an amino group from the group consisting of NH2, NHR and NRR? where R and R? are each a C1-C4 lower alkyl, Q is selected from the group consisting of 13CH2, 13CDH and 13CD2, and Z1 is selected from the group consisting of —S—, —S(?O)—, —S(?O)2—, —Se—, —Se(?O)—, and —Se(?O)2—, Z2 is selected from the group consisting of —Si(R6R7R8), —O(R9), —Se—Ar, —Se(?O)—Ar, —Se(?O)2—Ar, —S—Ar, —S(?O)—Ar, and —S(?O)2—Ar wherein R6, R7 and R8 are each independently selected from the group consisting of a C1-C4 lower alkyl, R9 is a C1-C4 lower alkyl or an R10—Ar group where R10 is a C1-C4 alkylene group.
    Type: Application
    Filed: June 29, 2005
    Publication date: January 4, 2007
    Inventors: Rodolfo Martinez, Jurgen Schmidt, Marc Alvarez, Louis Silks
  • Publication number: 20060178534
    Abstract: The present invention is directed to labeled compounds, of the formulae wherein C* is each independently selected from the group consisting of 13C and 12C with the proviso that at least one C* is 13C, each hydrogen of the methylene group can independently be either hydrogen or deuterium, the methyl group includes either zero or three deuterium atoms, Q is from the group of sulfide, sulfinyl, and sulfone, Z is an aryl group from the group of 1-naphthyl, substituted 1-naphthyl, 2-naphthyl, substituted 2-naphthyl, and phenyl groups with the structure wherein R1, R2, R3, R4 and R5 are each independently from the group of hydrogen, a C1-C4 lower alkyl, a halogen, and an amino group from the group of NH2, NHR and NRR? where R and R? are each independently from the group of a C1-C4 lower alkyl, a phenyl, and an alkoxy group, and the methyl group can include either zero or three deuterium atoms.
    Type: Application
    Filed: February 7, 2005
    Publication date: August 10, 2006
    Inventors: Rodolfo Martinez, Clifford Unkefer, Marc Alvarez
  • Publication number: 20050027146
    Abstract: The present invention is directed to asymmetric chiral labeled glycerols including at least one chiral atom, from one to two 13C atoms and from zero to four deuterium atoms bonded directly to a carbon atom, e.g., (2S)[1,2-13C2]glycerol and (2R)[1,2-13C2]glycerol, and to the use of such chiral glycerols in the preparation of labeled amino acids.
    Type: Application
    Filed: July 30, 2003
    Publication date: February 3, 2005
    Inventors: Rodolfo Martinez, Clifford Unkefer, Marc Alvarez
  • Patent number: 6831040
    Abstract: Increasing the concentration of prolines, such as 2-hydroxy-5-oxoproline, in the foliar portions of plants has been shown to cause an increase in carbon dioxide fixation, growth rate, dry weight, nutritional value (amino acids), nodulation and nitrogen fixation, photosynthetically derived chemical energy, and resistance to insect pests over the same properties for wild type plants.
    Type: Grant
    Filed: January 27, 2000
    Date of Patent: December 14, 2004
    Assignee: The Regents of the University of California
    Inventors: Pat J. Unkefer, Thomas J. Knight, Rodolfo A. Martinez