Patents by Inventor Rodolfo MURILLAS ANGOITI

Rodolfo MURILLAS ANGOITI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GENE EDITING FOR THE TREATMENT OF EPIDERMOLYSIS BULLOSA
    Publication number: 20230256026
    Abstract: The present invention relates to the treatment of Epidermolysis Bullosa, particularly the recessive dystrophic subtype (RDEB), using the Clustered- Regularly Interspaced Short Palindromic Repeats (CRISPR) system. This technology offers the possibility to design a single guide RNA (sgRNA) which is incorporated into a CRISPR- associated protein (Cas9) to recognize and induce DNA double-strand breaks at a specific target location. DNA double-strand breaks will be repaired by homologous recombination (HR) in the presence of a donor sequence for Epidermolysis Bullosa gene repair. In the context of Epidermolysis Bullosa, this allows to repair the mutation/s causing the disease.
    Type: Application
    Filed: January 20, 2021
    Publication date: August 17, 2023
    Inventors: José BONAFONT ARAGÓ, Fernando LARCHER LAGUZZI, Rodolfo MURILLAS ANGOITI, Marcela DEL RÍO NECHAEVSKY, Ángeles MENCÍA RODRIGUEZ, Marta GARCÍA DÍEZ, María José ESCÁMEZ TOLEDANO, Matthew PORTEUS