Abstract: An article comprising a bulk metallic glass skin having one or more functional features integrated therein is described and a method of forming the same is described. The one or more functional features exhibit a variation in stiffness between the one or more functional features and the bulk metallic glass skin that is defined by an applied force over an achieved deformation. The stiffness of each of the one or more functional features is at least 1000 times less than an average stiffness of the bulk metallic glass skin.

Abstract: This invention describes a method and hardware of how to deform metallic glasses under low force and stabilized conditions to fabricate thin and large area metallic glass sheets. It is based on a combination of thermoplastic rolling and stretching and typically combined with a pre-heating method. The predominant mode of deformation is dependent on the BMG conditions such as thickness, viscosity, and crystallization time.

Abstract: A reusable mold comprising a flexible bulk metallic glass mold insert comprising one or more mold cavities removably coupled to a support mold and a method of making the reusable mold. The support mold is removable from the flexible bulk metallic glass mold insert without macroscopic elastic flexing or deforming of the support mold. The reusable mold may be used for molding one or more bulk metallic glass parts and the one or more molded bulk metallic glass parts may be released from the flexible bulk metallic glass mold insert by elastically flexing the flexible mold insert.

Abstract: The present invention relates to the use of 4-anilinoquinazoline derivatives as adenosine-kinase inhibitors. The present invention also relates to a method for protecting tissues and organs like heart, brain and kidneys affected by ischemia, and for treating heart insufficiency, myocardium infarct, arrhythmia, arterial hypertension, atherosclerosis, coronary artery restenosis after angioplasty, chronic renal insufficiency, cerebral vascular accident, and chronic inflanunatory diseases (e.g., rheumatoid arthritis). The present invention also relates to the compound 6,7-dimethoxy-4-(3?-N?,N?-dimethylaminoanilino)quinazoline, or a pharmaceutically acceptable salt thereof, pharmaceutical composition comprising it and use of such compound in the manufacture of a medicament for treating or preventing diseases or conditions that are benefited from the adenosine-kinase inhibition.