Abstract: The disclosure features methods of modifying a cell or tissue in vivo with lipid nanoparticle (LNP) compositions comprising a payload. The LNP compositions of the present disclosure can modify a parameter associated with the cell or tissue; or modify a component associated with the cell or tissue. Further disclosed are methods of treating a subject having a disease, a disorder, a mutation, or a single nucleotide polymorphism (SNP), comprising administering to the subject an effective amount of an LNP composition comprising a payload. Also disclosed herein are LNP compositions comprising a payload and methods of making the same.

Abstract: Provided herein are combination therapies comprising an alpha4beta7 inhibitor, e.g., an anti-alpha4beta7 antibody, e.g., vedolizumab, and an IL-23 inhibitor, e.g., an anti-IL-23 antibody.

Abstract: Embodiments of current feedback circuits for Direct Current (DC)-DC converters and methods for operating current feedback circuits for DC-DC converters are described. In one embodiment, a current feedback circuit for a DC-DC converter includes a current replication circuit configured to provide current feedback to the DC-DC converter based on an on-time of the DC-DC converter and an alternating current (AC)-coupling circuit configured to add the current feedback to a regulation circuit of the current feedback circuit and to remove a DC voltage from the current replication circuit. The regulation circuit includes a filter circuit configured to compensate for an offset of an output voltage of the DC-DC converter caused by the current feedback. Other embodiments are also described.

Abstract: Embodiments of current feedback circuits for Direct Current (DC)-DC converters and methods for operating current feedback circuits for DC-DC converters are described. In one embodiment, a current feedback circuit for a DC-DC converter includes a current replication circuit configured to provide current feedback to the DC-DC converter based on an on-time of the DC-DC converter and an alternating current (AC)-coupling circuit configured to add the current feedback to a regulation circuit of the current feedback circuit and to remove a DC voltage from the current replication circuit. The regulation circuit includes a filter circuit configured to compensate for an offset of an output voltage of the DC-DC converter caused by the current feedback. Other embodiments are also described.

Abstract: T cells are programmed to target the gastrointestinal tract by activation with dendritic cells capable of producing and/or transporting retinoic acid. Methods for using the programmed dendritic cells and/or T and/or B cells to treat a variety of pathogens and infectious agents residing in the intestine are also disclosed. Similarly, inhibitors of retinoic acid synthesis by dendritic cells or other cells in the gut, and inhibitors of retinoic acid receptors in T and/or B cells or other cells in the intestinal mucosa, are disclosed for treating a variety of gastrointestinal autoimmune diseases such as inflammatory bowel disease and celiac disease.