Abstract: Therapeutic compositions and an associated method for improving a Toll-like receptor (TLR)-related condition, including determining a set of peptide sequences associated with a microorganism-related modulator of a TLR, determining a first set of binding parameters for the set of peptide sequences in relation to the TLR, selecting a target subset of peptide sequences from the set of peptide sequences based on the first set of binding parameters, reengineering the target subset of peptide sequences based on mutating amino acid residues of the target subset of peptide sequences, determining a second set of binding parameters for the reengineered target subset of peptide sequences in relation to the TLR, and identifying a first peptide for use in a therapeutic composition for improving the TLR-related condition, based on the second set of binding parameters for the reengineered target subset of peptide sequences.

Abstract: Multipurpose product with prolonged antimicrobial action comprising at least one quaternary ammonium and copper nanoparticles in non-oxidized metallic state (Cu0), where copper nanoparticles in non-oxidized metallic state (Cu0) are found nucleated in at least one quaternary ammonium. A method for producing a multipurpose product with prolonged antimicrobial action.

Abstract: The invention refers to a method and doses in the administration of drugs for conscious sedation of a patient to be used in surgeries, including spinal column endoscopic surgery and other surgeries, as well as other applications inside or outside the operating theater using bio-backfeed or communication with the patient him/herself. Conscious sedation in surgeries, including spine or similar or other surgeries and applications inside and outside the operating theater permit the surgeon a greater risk control, e.g. injure the patient column or other organs or parts of the patient who, when being watchful there is communication with the patient, but it does not occur at present in operations involving general anesthesia; the latter includes column or similar surgeries, other surgeries and applications inside and outside the operating theater.

Abstract: An endoscopic screening system uses an apparatus has an endoscope with an upper/lower wheel and a right/left wheel for controlling bending of an endoscope tip within an organ being imaged; an intelligent mouthpiece adapted to precisely measure inclination of the endoscope using marks in degrees in both the novel mouth piece and in the new shaft; an endoscope shaft having both cross and longitudinal marks along a longitudinal length for digitalization of output to precisely obtain the length of insertion from a reference point to a tip of the endoscope; and an angulation device for measuring rotation of the upper/lower and right/left wheels. Every portion/part/side located within an organ is already assigned an alphanumeric code as part of the new nomenclature. The endoscopic screening system allows for imaging sequentially of an entire interior surface of a portion of the patient's gastrointestinal tract and image reconstruction of the surface with overlapping redundant pictures without image gaps.

Abstract: An endoscopic screening system uses an apparatus has an endoscope with an upper/lower wheel and a right/left wheel for controlling bending of an endoscope tip within an organ being imaged; an intelligent mouthpiece adapted to precisely measure inclination of the endoscope using marks in degrees in both the novel mouth piece and in the new shaft; an endoscope shaft having both cross and longitudinal marks along a longitudinal length for digitalization of output to precisely obtain the length of insertion from a reference point to a tip of the endoscope; and an angulation device for measuring rotation of the upper/lower and right/left wheels. Every portion/part/side located within an organ is already assigned an alphanumeric code as part of the new nomenclature. The endoscopic screening system allows for imaging sequentially of an entire interior surface of a portion of the patient's gastrointestinal tract and image reconstruction of the surface with overlapping redundant pictures without image gaps.

Abstract: A wind resistant sign enabled with a release mechanism providing for the sign pivoting from a starting point about an axis when the sign is exposed to a user determined threshold wind speed and a mechanism for returning the sign to its starting point when the wind speed decreases below the threshold. The sign pivot is the sign support and can be horizontal or vertical. The sign release mechanism can be as simple as a frangible locking element which is broken under sufficient wind velocity, a lock requiring a human operator to open, a lock controlled by a sensor, such as an anemometer, or a locking element responsive to a radio signal from a remote location. The return mechanism can be as simple as a spring for small signs, or a torque unit, such as a motor, for signs up to hundreds or thousands of kilograms.