Abstract: Systems and methods of radiograph correction and visualization are disclosed. Certain embodiments provide a method for generating a 3D model of at least part of one anatomical object based on one or more radiographs. The method further includes positioning the 3D model based on information indicative of a normalized projection comprising information indicative of a desired position and orientation of the at least part of one anatomical object with respect to the projection plane. The method further includes generating a 2D projection of the 3D model onto the projection plane. The method further includes generating one or more modified radiographs of the at least part of one anatomical object based on the 2D projection.

Abstract: Certain embodiments described herein relate to systems and methods for determining implant configuration or design of implants by taking into account soft tissues and utilizing patient-specific simulations of activities of daily living.

Abstract: Systems and methods of providing augmented reality assisted surgery are disclosed. Certain aspects provide a method including generating a virtual scene comprising one or more virtual elements comprising one or more anatomical elements corresponding to one or more anatomy parts. The method further includes identifying one or more references in an actual physical scene comprising the one or more anatomy parts. The method further includes registering the virtual scene to the one or more references to generate an augmented scene. The method further includes displaying the augmented scene on a display device.

Abstract: Systems and methods of radiograph correction and visualization are disclosed. Certain embodiments provide a method for generating a 3D model of at least part of one anatomical object based on one or more radiographs. The method further includes positioning the 3D model based on information indicative of a normalized projection comprising information indicative of a desired position and orientation of the at least part of one anatomical object with respect to the projection plane. The method further includes generating a 2D projection of the 3D model onto the projection plane. The method further includes generating one or more modified radiographs of the at least part of one anatomical object based on the 2D projection.

Abstract: A two-step approach for image segmentation during the treatment planning process is disclosed. In a first step, an automatic segmentation method can be used to generate a first, provisional segmentation. The first, provisional segmentation may be generated using fast, but less accurate segmentation methods. The first provisional segmentation may be used to generate a default treatment plan for approval. Once the default treatment plan is approved, a more robust, second image segmentation may be performed. The second segmentation may be used to design patient-specific devices that can be used to deliver the patient-specific medical treatment.

Abstract: Systems and methods of radiograph correction and visualization are disclosed. Certain embodiments provide a method for generating a 3D model of at least part of one anatomical object based on one or more radiographs. The method further includes positioning the 3D model based on information indicative of a normalized projection comprising information indicative of a desired position and orientation of the at least part of one anatomical object with respect to the projection plane. The method further includes generating a 2D projection of the 3D model onto the projection plane. The method further includes generating one or more modified radiographs of the at least part of one anatomical object based on the 2D projection.

Abstract: Certain embodiments described herein relate to systems and methods for determining implant configuration or design of implants by taking into account soft tissues and utilizing patient-specific simulations of activities of daily living.

Abstract: A two-step approach for image segmentation during the treatment planning process is disclosed. In a first step, an automatic segmentation method can be used to generate a first, provisional segmentation. The first, provisional segmentation may be generated using fast, but less accurate segmentation methods. The first provisional segmentation may be used to generate a default treatment plan for approval. Once the default treatment plan is approved, a more robust, second image segmentation may be performed. The second segmentation may be used to design patient-specific devices that can be used to deliver the patient-specific medical treatment.

Abstract: The present invention relates to an adaptable therapeutic, diagnostic or surgical guide for an intra-operative adjustment of a guidance element to a pre-planned position. An advantage and innovation of the present invention is that it provides a template or guide that adapts in a controlled way to a changed intra-operative anatomical situation compared to the default planned situation. This adaption maybe purely positional but it may also include force feedback. Feedback, either visual feedback or force feedback that results in an adjustment of a guidance element is also an aspect of the present invention. For example, the feedback can contain information either about the fit of the guide or template onto a bone (in case the guide or template fits onto one bone) or about the relative position of two bones of bone fragments (e.g. ligament tension between the femur and tibia).

Abstract: The present invention is related to a method for re-enabling transport by means of a magnetic field gradient transport mechanism of magnetic beads comprising a ligand in a solution on top of a surface comprising a receptor bound with said ligand, comprising the step of changing the properties of said solution such that dissociation occurs between said ligand and said receptor, and such that a sufficient repulsive interaction is created between said surface and said bead to allow transport of said bead.

Abstract: The present invention relates to an adaptable therapeutic, diagnostic or surgical guide for an intra-operative adjustment of a guidance element to a pre-planned position. An advantage and innovation of the present invention is that it provides a template or guide that adapts in a controlled way to a changed intra-operative anatomical situation compared to the default planned situation. This adaption maybe purely positional but it may also include force feedback. Feedback, either visual feedback or force feedback that results in an adjustment of a guidance element is also an aspect of the present invention. For example, the feedback can contain information either about the fit of the guide or template onto a bone (in case the guide or template fits onto one bone) or about the relative position of two bones of bone fragments (e.g. ligament tension between the femur and tibia).

Abstract: A method and magnetic device for improving the desirable properties of a magnetic device, e.g., magnetization uniformity and reproducibility. Moreover the invention provides magnetic cells that are more magnetically homogeneous, with smaller amount of end domain magnetization canting from the average cell magnetization direction. The invention may provide a magnetic memory cell with less variation in switching fields, more spatially coherent dynamical magnetic properties for high speed and processional or coherent magnetic switching, and higher signal due to the increased uniformity. It may provide a magnetic sensor with more spatially coherent magnetic properties for high speed and processional or coherent magnetic switching, and increased signal. It may provide a read head element with more spatially coherent magnetic properties for high speed and processional or coherent magnetic sensing, and increased signal.

Abstract: The present invention is related to a method for re-enabling transport by means of a magnetic field gradient transport mechanism of magnetic beads comprising a ligand in a solution on top of a surface comprising a receptor bound with said ligand, comprising the step of changing the properties of said solution such that dissociation occurs between said ligand and said receptor, and such that a sufficient repulsive interaction is created between said surface and said bead to allow transport of said bead.

Abstract: The present invention is related to a method for controlled transport of magnetic beads between a position X and different position Y, such that the magnetic beads are manipulated or transported by applying successively a series of N local magnetic fields which have magnetic field gradients different from 0 in the neighborhood of said magnetic beads. Each of these N local magnetic fields is generated by a single current carrying structure, in which the current density is not constant. The invention generally relates to application in the domain of biochips and micro-arrays, used in diagnostics, genetics and molecular studies.

Abstract: The present invention is related to a method for controlled transport of magnetic beads between a position X and different position Y, such that the magnetic beads are manipulated or transported by applying successively a series of N local magnetic fields which have magnetic field gradients different from 0 in the neighborhood of said magnetic beads. Each of these N local magnetic fields is generated by a single current carrying structure, in which the current density is not constant. The invention generally relates to application in the domain of biochips and micro-arrays, used in diagnostics, genetics and molecular studies.

Abstract: The present invention is related to a method and corresponding devices for controlled transport of magnetic beads between a position X and different position Y, such that the magnetic beads are manipulated or transported by applying successively a series of N local magnetic fields which have magnetic field gradients different from 0 in the neighborhood of said magnetic beads. Each of these N local magnetic fields is generated by a single current carrying structure, in which the current density is not constant. The invention mainly points to application in the domain of biochips and microarrays, used in diagnostics, genetics and molecular studies.

Abstract: A method and magnetic device for improving the desirable properties of a magnetic device, e.g., magnetization uniformity and reproducibility. Moreover the invention provides magnetic cells that are more magnetically homogeneous, with smaller amount of end domain magnetization canting from the average cell magnetization direction. The invention may provide a magnetic memory cell with less variation in switching fields, more spatially coherent dynamical magnetic properties for high speed and processional or coherent magnetic switching, and higher signal due to the increased uniformity. It may provide a magnetic sensor with more spatially coherent magnetic properties for high speed and processional or coherent magnetic switching, and increased signal. It may provide a read head element with more spatially coherent magnetic properties for high speed and processional or coherent magnetic sensing, and increased signal.

Abstract: A method and magnetic device for improving the desirable properties of a magnetic device, e.g., magnetization uniformity and reproducibility. Moreover the invention provides magnetic cells that are more magnetically homogeneous, with smaller amount of end domain magnetization canting from the average cell magnetization direction. The invention may provide a magnetic memory cell with less variation in switching fields, more spatially coherent dynamical magnetic properties for high speed and processional or coherent magnetic switching, and higher signal due to the increased uniformity. It may provide a magnetic sensor with more spatially coherent magnetic properties for high speed and processional or coherent magnetic switching, and increased signal. It may provide a read head element with more spatially coherent magnetic properties for high speed and processional or coherent magnetic sensing, and increased signal.

Abstract: The present invention is related to a method and corresponding devices for controlled transport of magnetic beads between a position X and different position Y, wherein said magnetic beads are manipulated or transported by applying successively a series of N local magnetic fields which have magnetic field gradients different from 0 in the neighborhood of said magnetic beads. Each of these N local magnetic fields is generated by a single current carrying structure, in which the current density is not constant. The invention mainly points to application in the domain of biochips and microarrays, used in diagnostics, genetics and molecular studies.

Abstract: A method and magnetic device for improving the desirable properties of a magnetic device, e.g., magnetization uniformity and reproducibility. Moreover the invention provides magnetic cells that are more magnetically homogeneous, with smaller amount of end domain magnetization canting from the average cell magnetization direction. The invention may provide a magnetic memory cell with less variation in switching fields, more spatially coherent dynamical magnetic properties for high speed and processional or coherent magnetic switching, and higher signal due to the increased uniformity. It may provide a magnetic sensor with more spatially coherent magnetic properties for high speed and processional or coherent magnetic switching, and increased signal. It may provide a read head element with more spatially coherent magnetic properties for high speed and processional or coherent magnetic sensing, and increased signal.