Patents by Inventor Roeland Nusse

Roeland Nusse has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions of active Wnt protein
    Publication number: 20040248803
    Abstract: Compositions of purified biologically active Wnt proteins are provided. Wnt proteins are found to be hydrophobic and post-translationally modified by addition of a lipid moiety at a conserved cysteine residue. Methods for isolation of Wnt utilize detergents that maintain the solubility of the modified protein.
    Type: Application
    Filed: April 1, 2004
    Publication date: December 9, 2004
    Inventors: Roeland Nusse, Karl H. Willert
  • Wnt receptor compositions and methods
    Publication number: 20030040051
    Abstract: Wnt receptor compositions and methods of use are disclosed. In particular, methods using Wnt receptors, such as Dfz2, in screens for compounds which modulate the binding of a Wnt polypeptide to a Wnt receptor.
    Type: Application
    Filed: May 21, 2002
    Publication date: February 27, 2003
    Inventors: Purnima Bhanot, Marcel Brink, Cindy H. Samos, Yanshu Wang, Jen-Chih Hsieh, Deborah Andrew, Jeremy Nathans, Roeland Nusse
  • Use of &bgr;-catenin in the expansion of stem and progenitor cells
    Patent number: 6465249
    Abstract: Mammalian progenitor or stem cells are expanded in vitro by increasing the levels of &bgr;-catenin in the cell. The expanded cells substantially maintain their original phenotype including the ability to give rise to multiple types of differentiated cells. The intracellular levels of &bgr;-catenin may be manipulated by providing exogenous &bgr;-catenin protein to the cell, or by introduction into the cell of a genetic construct encoding &bgr;-catenin. The &bgr;-catenin may be a wild-type or stabilized mutant form of the protein. Preferably the long term cell culture medium substantially lacks stromal cells and cytokines.
    Type: Grant
    Filed: January 18, 2001
    Date of Patent: October 15, 2002
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Tannishtha Reya, Roeland Nusse, Irving L. Weissman
  • Use of beta-catenin in the expansion of stem and progenitor cells
    Publication number: 20020004241
    Abstract: Mammalian progenitor or stem cells are expanded in vitro by increasing the levels of &bgr;-catenin in the cell. The expanded cells substantially maintain their original phenotype including the ability to give rise to multiple types of differentiated cells. The intracellular levels of &bgr;-catenin may be manipulated by providing exogenous &bgr;-catenin protein to the cell, or by introduction into the cell of a genetic construct encoding &bgr;-catenin. The &bgr;-catenin may be a wild-type or stabilized mutant form of the protein. Preferably the long term cell culture medium substantially lacks stromal cells and cytokines.
    Type: Application
    Filed: January 18, 2001
    Publication date: January 10, 2002
    Inventors: Tannishtha Reya, Roeland Nusse, Irving L. Weissman