Patents by Inventor Roelant J. Siezen

Roelant J. Siezen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Lantibiotics similar to nisin a
    Patent number: 5594103
    Abstract: The invention relates primarily to a number of lantibiotics similar to nisin A, which differ from nisin A by substitution, deletion or insertion of one or more amino acids, such as the naturally occurring analog of nisin A, termed nisin Z. Lantibiotics of this type are particularly suitable for preserving foodstuffs for humans and animals. This preservation takes place by the use of these lantibiotics themselves or of microorganisms producing these lantibiotics, in particular lactic acid bacteria, in the preparation or storage of foodstuffs.
    Type: Grant
    Filed: October 7, 1993
    Date of Patent: January 14, 1997
    Assignee: Stichting Nederlands Instituut Voor Zuivelonderzoek (NIZO)
    Inventors: Willem M. De Vos, Roelant J. Siezen, Oscar P. Kuipers
  • Chemical prevention or reversal of cataract by phase separation inhibitors
    Patent number: 5290813
    Abstract: The present invention relates to methods and pharmaceutical reagents for decreasing the phase separation temperature and inhibiting the formation of high molecular weight aggregates in eye lenses, thereby inhibiting or reversing cataract formation.
    Type: Grant
    Filed: August 9, 1993
    Date of Patent: March 1, 1994
    Assignee: Massachusetts Institute of Technology
    Inventors: John I. Clark, Geroge B. Benedek, Roelant J. Siezen, John A. Thomson, Simon H. Friedman
  • Chemical prevention or reversal of cataract by phase separation inhibitors
    Patent number: 5091421
    Abstract: The present invention relates to methods and pharmaceutical reagents for decreasing the phase separation temperature and inhibiting the formation of high molecular weight aggregates in eye lenses, thereby inhibiting or reversing cataract formation.
    Type: Grant
    Filed: December 15, 1989
    Date of Patent: February 25, 1992
    Assignee: Massachusetts Institute of Technology
    Inventors: John I. Clark, George B. Benedek, Roelant J. Siezen, John A. Thomson, Simon H. Friedman
  • Process for preventing or reversing cataract formation using protein modification reagents
    Patent number: 4665089
    Abstract: Cataract in mammalian lenses can be prevented or reversed by applying a solution of an imidoester, a N-hydroxysuccinimide-ester or hydrogen peroxide to the lens under conditions that permit the solution to interact with the lens constituents.
    Type: Grant
    Filed: March 21, 1985
    Date of Patent: May 12, 1987
    Assignee: Massachusetts Institute of Technology
    Inventors: Roelant J. Siezen, Christophe M. Coppin, George B. Benedek