Patents by Inventor Roelof M. L. Rongen

Roelof M. L. Rongen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8871800
    Abstract: Methods of utilizing a combined administration or a unit dosage of a combination of an HMG-CoA inhibitor and omega-3 fatty acids for the reduction of apolipoprotein-B levels. The methods are especially useful in the treatment of patients with hypertriglyceridemia or hypercholesterolemia or mixed dyslipidemia, coronary heart disease (CHD), vascular disease, atherosclerotic disease and related conditions, and for the prevention or reduction of cardiovascular, cardiac, and vascular events.
    Type: Grant
    Filed: September 17, 2009
    Date of Patent: October 28, 2014
    Assignee: GlaxoSmithKline, LLC
    Inventors: Roelof M. L. Rongen, Robert A. Shalwitz, Douglas Kling, Ralph T. Doyle, Jr.
  • Publication number: 20110251275
    Abstract: Methods are provided for utilizing omega-3 fatty acids, or a combination of a dyslipidemic agent and omega-3 fatty acids, for the reduction of lipoprotein-associated phospholipase A2 (Lp-PLA2) levels. The methods are especially useful in the treatment of patients with primary hypercholesterolemia or hypertriglyceridemia or mixed dyslipidemia, coronary heart disease (CHD), vascular disease, atherosclerotic disease and related conditions, and for the prevention or reduction of major adverse cardiovascular events (MACE), major coronary events (MCE), particularly myocardial infarction (MI), revascularizations and ischemic stroke.
    Type: Application
    Filed: January 10, 2011
    Publication date: October 13, 2011
    Inventors: Roelof M.L. Rongen, Douglas Kling, Ralph T. Doyle, JR., Robert A. Shalwitz
  • Patent number: 8026281
    Abstract: A method of treating metabolic syndrome in a human diagnosed with metabolic syndrome by administering a therapeutically effective amount of fenofibrate over a treatment period. The results can include identifying a human as not having clinical metabolic syndrome after treatment, as compared to having metabolic syndrome before treatment.
    Type: Grant
    Filed: April 22, 2005
    Date of Patent: September 27, 2011
    Assignee: Lupin Atlantis Holdings, S.A.
    Inventors: Ralph T. Doyle, Jr., Douglas F. Kling, Roelof M. L. Rongen, Keith S. Rotenberg
  • Publication number: 20110092563
    Abstract: A method of lipid therapy, comprising providing a subject group having a baseline triglyceride level of 200 to 499 mg/dl and being at or near its low-density lipoprotein cholesterol (LDL-C) level goal, and reducing the triglyceride level and the non-high-density lipoprotein cholesterol (non-HDL-C) level of the subject group as compared to treatment with a 3-hydroxy-3-methyl glutaryl coenzyme A (HMG CoA) inhibitor alone, by administering to the subject group an effective amount of an HMG CoA inhibitor and a composition comprising omega-3 fatty acids.
    Type: Application
    Filed: December 23, 2010
    Publication date: April 21, 2011
    Inventors: George Bobotas, Roelof M. L. Rongen, Egil Bodd, Hogne Vik
  • Publication number: 20100010026
    Abstract: Methods of utilizing a combined administration or a unit dosage of a combination of an HMG-CoA inhibitor and omega-3 fatty acids for the reduction of apolipoprotein-B levels. The methods are especially useful in the treatment of patients with hypertriglyceridemia or hypercholesterolemia or mixed dyslipidemia, coronary heart disease (CHD), vascular disease, atherosclerotic disease and related conditions, and for the prevention or reduction of cardiovascular, cardiac, and vascular events.
    Type: Application
    Filed: September 17, 2009
    Publication date: January 14, 2010
    Inventors: Roelof M.L. RONGEN, Robert A. SHALWITZ, Douglas KLING, Ralph T. DOYLE, JR.
  • Publication number: 20090239927
    Abstract: A method of lipid therapy, comprising providing a subject group having a baseline triglyceride level of 200 to 499 mg/dl and being at or near its low-density lipoprotein cholesterol (LDL-C) level goal, and reducing the triglyceride level and the non-high-density lipoprotein cholesterol (non-HDL-C) level of the subject group as compared to treatment with a 3-hydroxy-3-methyl glutaryl coenzyme A (HMG CoA) inhibitor alone, by administering to the subject group an effective amount of an HMG CoA inhibitor and a composition comprising omega-3 fatty acids.
    Type: Application
    Filed: October 23, 2008
    Publication date: September 24, 2009
    Inventors: George Bobotas, Roelof M. L. Rongen, Egil Bodd, Hogne Vik
  • Publication number: 20090182022
    Abstract: Methods and compositions comprising peroxisomal and/or mitochondrial beta oxidation stimulating agents to reverse or resolve, slow the progression of, treat or prevent the development of fatty liver and conditions stemming from fatty liver, such as NASH, liver inflammation, cirrhosis and liver failure. An active agent that by itself is associated with an increased risk of fatty liver development and conditions stemming from fatty liver, such as NASH, liver inflammation, cirrhosis and liver failure, may be administered in combination with peroxisomal and/or mitochondrial beta oxidation stimulating agents. A combination regimen involving such agents, as simultaneous or concomitant therapy, or as a fixed dosage form, is also provided.
    Type: Application
    Filed: January 5, 2007
    Publication date: July 16, 2009
    Inventors: Roelof M. L. Rongen, Robert A. Shalwitz, Ihor Terleckyj
  • Publication number: 20090012167
    Abstract: A method and composition for blood lipid therapy by administering to the subject an effective amount of a dyslipidemic agent and omega-3 fatty acids. The method utilizes a single administration or a unit dosage of a combination of dyslipidemic agent and omega-3 fatty acids for the treatment of patients with hypertriglyceridemia, hypercholesterolemia, mixed dyslipidemia, coronary heart disease (CHD), vascular disease, artherosclerotic disease and related conditions, and the prevention or reduction of cardiovascular and vascular events.
    Type: Application
    Filed: September 15, 2008
    Publication date: January 8, 2009
    Applicants: RELIANT PHARMACEUTICALS, INC., PRONOVA BIOCARE AS
    Inventors: Roelof M. L. RONGEN, George BOBOTAS, Egil BODD, Hogne VIK
  • Publication number: 20080085911
    Abstract: Methods of utilizing a combined administration or a unit dosage of a combination of an HMG-CoA inhibitor and omega-3 fatty acids for the reduction of apolipoprotein-B levels. The methods are especially useful in the treatment of patients with hypertriglyceridemia or hypercholesterolemia or mixed dyslipidemia, coronary heart disease (CHD), vascular disease, atherosclerotic disease and related conditions, and for the prevention or reduction of cardiovascular, cardiac, and vascular events.
    Type: Application
    Filed: September 7, 2007
    Publication date: April 10, 2008
    Applicant: Reliant Pharmaceuticals, Inc.
    Inventors: Roelof M.L. Rongen, Robert A. Shalwitz, Douglas Kling, Ralph T. Doyle
  • Publication number: 20060188529
    Abstract: A pharmaceutical composition in unit dose form of fenofibrate and a solvent system of fatty acid esters, wherein the fenofibrate is substantially dissolved in the solvent system.
    Type: Application
    Filed: December 5, 2005
    Publication date: August 24, 2006
    Inventors: George Bobotas, Roelof M.L. Rongen, Abdel Fawzy