Patents by Inventor Rogelio Frutos

Rogelio Frutos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Preparation of dihydrothieno [3,2-D] pyrimidines and intermediates used therein
    Patent number: 8653282
    Abstract: The invention relates to improved methods of preparing dihydrothienopyrimidines of formula 1, and intermediates thereof, (I) wherein X is SO or SO2, preferably SO, and wherein RA, R1, R2, R3, R4 and R5 have the meanings given in the description. The methods according to this invention are more suitable for large-scale synthesis of said compounds than prior methods because the new synthetic process avoids distillation and chromatographic purification between steps and results in a higher overall yield of the desired product.
    Type: Grant
    Filed: October 15, 2008
    Date of Patent: February 18, 2014
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Rogelio Frutos, Dhileepkumar Krishnamurthy, Jason Alan Mulder, Sonia Rodriguez, Chris Hugh Senanayake, Thomas G. Tampone
  • PREPARATION OF DIHYDROTHIENO [3, 2-D] PYRIMIDINES AND INTERMEDIATES USED THEREIN
    Publication number: 20100222585
    Abstract: The invention relates to improved methods of preparing dihydrothienopyrimidines of formula 1, and intermediates thereof, (I) wherein X is SO or SO2, preferably SO, and wherein RA, R1, R2, R3, R4 and R5 have the meanings given in the description. The methods according to this invention are more suitable for large-scale synthesis of said pounds than prior methods because the new synthetic process avoids distillation and chromatographic purification between steps and results in a higher overall yield of the desired product.
    Type: Application
    Filed: October 15, 2008
    Publication date: September 2, 2010
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Rogelio Frutos, Dhileepkumar Krishnamurthy, Jason Alan Mulder, Sonia Rodriguez, Chris Hugh Senanayake, Thomas G. Tampone
  • Bis-Amination of Aryl Halides
    Publication number: 20060258888
    Abstract: Disclosed are methods for making 1,3- and 1,4-diamino-phenyl intermediates by utilizing bis-amination of ortho-substituted aryl halides.
    Type: Application
    Filed: May 1, 2006
    Publication date: November 16, 2006
    Applicant: Boehringer Ingelheim International, GmbH
    Inventors: Rogelio Frutos, Isabelle Gallou, Dhileepkumar Krishnamurthy, Xiufeng Sun
  • Synthesis of 6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonic acid amides
    Publication number: 20060025447
    Abstract: Disclosed is a multi-step process for preparing a compound of Formula I: wherein R1 to R3 are as defined herein. The compounds of formula I inhibit the binding of human intercellular adhesion molecules to the Leukointegrins. As a result, these compounds are useful in the treatment of inflammatory and immune cell-mediated diseases.
    Type: Application
    Filed: July 25, 2005
    Publication date: February 2, 2006
    Applicants: Boehringer Ingelheim Pharmaceuticals, Inc., Boehringer Ingelheim International GmbH
    Inventors: Xiao-Jun Wang, Thomas Wirth, Thomas Nicola, Li Zhang, Rogelio Frutos, Yibo Xu, Dhileopkumar Krishnamurihy, Laurence Nummy, Richard Varsolona, Chris Senanayake, Jutta Kroeber
  • Process for preparing acyclic HCV protease inhibitors
    Publication number: 20050267151
    Abstract: Disclosed are highly convergent processes for preparing compounds of formula (I), which compounds are potent active agents for the treatment of hepatitis C virus (HCV) infection: The disclosed processes use SNAr-type coupling reactions between peptidic compounds having a hydroxyproline moiety of the following formula: and halogenated or sulfonated bromoquinoline compounds.
    Type: Application
    Filed: May 23, 2005
    Publication date: December 1, 2005
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Carl Busacca, Rogelio Frutos, Nizar Haddad, Suresh Kapadia, Jon Lorenz, Anjan Saha, Chris Senanayake, Xudong Wei
  • Process for preparing macrocyclic compounds
    Publication number: 20050049187
    Abstract: Disclosed is a process for preparing a macrocyclic compound of the formula (I): which is carried out using an intermediate of the formula (II): wherein W, R1 through R4, D, A and R12 are as defined herein. The compounds of formula (I) are potent active agents for the treatment of hepatitis C virus (HCV) infection.
    Type: Application
    Filed: April 6, 2004
    Publication date: March 3, 2005
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Joerg Brandenburg, Kai Donsbach, Hans-Dieter Ecker, Rogelio Frutos, Fabrice Gallou, Dieter Gutheil, Nizar Haddad, Robert Hagenkoetter, Dirk Kemmer, Jutta Kroeber, Thomas Nicola, Juergen Schnaubelt, Michael Schul, Robert Simpson, Xudong Wei, Eric Winter, Yibo Xu, Nathan Yee