Abstract: This invention relates to a synthetic method for the preparation of Compound 1 and precursors thereof. Compound 1 is prepared via reaction of isoxazole 2 with phenylether (R)-3-ONa.

Abstract: An antibody or fragment thereof, against presenilin, and more specifically against the luminal loop 1 of presenilin, for use in the treatment of cancer, by way of administrating a therapeutically effective quantity of the antibody or a fragment thereof, or a pharmaceutical composition comprising thereof, to a subject who suffers from cancer.

Abstract: In the present invention, gelled polymeric compositions for controlled release are described, which admit the incorporation of a range of chemical, pharmaceutical or food substances, in order to be a transport towards the gastrointestinal tract. The gelled polymeric compositions as described in the invention are used as the basis for the preparation of, for example: excipients, vehicles, coatings, films, hydrogels, among others, thus being highly profitable for the development of products for the pharmaceutical industry and/or the food industry.

Abstract: A method of setting actuator position of a variable geometry turbine linked to drive a compressor for a compression ignition engine using exhaust gas recirculation. The method includes detecting an engine transient event; determining current mass air flow through the compressor and exhaust temperature; resetting variable geometry turbine position to maximize mass air flow through the compressor; adding the maximum allowable quantity of fuel; determining exhaust temperature increase; adjusting exhaust pressure to allow an increase in mass air flow and exhaust temperature; and returning to the resetting step until a limit is reached.

Abstract: A system for operating a vehicle equipped with an automatic transmission and a vehicle road speed limiter (RSL) which is programmable to limit the maximum vehicle speed for a given transmission gear includes at least on controller. The at least one controller is operable, when the speed limiter (RSL) is active, to determine if the vehicle is operating in a shuttle shifting range based on the current status of preselected operating parameters. When the vehicle is operating in a shuttle shifting range, the at least one controller is operable to control transmission operation to prevent shifting under conditions where shifting would otherwise normally occur.

Abstract: A method of setting actuator position of a variable geometry turbine linked to drive a compressor for a compression ignition engine using exhaust gas recirculation. The method includes detecting an engine transient event; determining current mass air flow through the compressor and exhaust temperature; resetting variable geometry turbine position to maximize mass air flow through the compressor; adding the maximum allowable quantity of fuel; determining exhaust temperature increase; adjusting exhaust pressure to allow an increase in mass air flow and exhaust temperature; and returning to the resetting step until a limit is reached.

Abstract: According to at least one aspect of the present technology, a method is provided for compensating the output of a mass air flow sensor in response to humidity level. The method includes determining an actual mass air flow value (MAF_ACT) using the mass air flow sensor. The method also includes determining an actual humidity value (HUM_ACT) of the air flow that is measured by the mass air flow sensor. The method further includes determining if the actual humidity value (HUM_ACT) is outside of a preselected operating range. If the actual humidity value (HUM_ACT) is outside of the preselected operating range, the method determines a humidity-compensated mass air flow value (MAF_HUM) as a function of the actual mass air flow value (MAF_ACT) and the actual humidity value (HUM_ACT).

Abstract: A system for operating a vehicle equipped with an automatic transmission and a vehicle road speed limiter (RSL) which is programmable to limit the maximum vehicle speed for a given transmission gear includes at least on controller. The at least one controller is operable, when the speed limiter (RSL) is active, to determine if the vehicle is operating in a shuttle shifting range based on the current status of preselected operating parameters. When the vehicle is operating in a shuttle shifting range, the at least one controller is operable to control transmission operation to prevent shifting under conditions where shifting would otherwise normally occur.

Abstract: A motor vehicle has wheels on which it travels, a powertrain delivering propulsion torque to at least some of the wheels propel the vehicle, and a service brake system having service brakes. When the service brakes are applied by a service brake actuator, braking torque is applied to at least some wheels. A first device provides data representing a velocity that correlates with velocity of the vehicle, and a second device associated with the actuator provides data that distinguishes between application and non-application of the service brakes by the actuator. A processor monitors data from the first and second devices and processes the monitored data to provide a data output when the first device has disclosed velocity change indicative of the service brakes having been applied without the second device having disclosed that the service brakes have been applied.

Abstract: An EGR control method to prevent condensation within the EGR system uses a temperature sensor signal from an EGR cooler exhaust gas outlet to model or estimate exhaust manifold gas temperature upstream of the cooler. If the estimated exhaust manifold gas temperature falls below a predetermined level, the engine control system closes or partially closes the EGR control valve to stop EGR flow through the cooler and the EGR valve.

Abstract: An engine processor (38) processes data for inferring temperature of exhaust gas at an exhaust manifold (18) of an internal combustion engine (10) whose exhaust system (16) contains an after-treatment device (26, 28) for treating exhaust gas and a sensor (30) for providing data for temperature of exhaust gas entering the after-treatment device. The processor processes data from the sensor and other data to infer temperature of exhaust gas at the exhaust manifold by executing an algorithm (FIGS. 3 and 4) that models temperature of exhaust gas at the exhaust manifold as a function of data from the sensor and the other data, including certain constants, certain geometry of the exhaust system, and certain variables related to operation of the engine.

Abstract: An EGR control method to prevent condensation within the EGR system uses a temperature sensor signal from an EGR cooler exhaust gas outlet to model or estimate exhaust manifold gas temperature upstream of the cooler. If the estimated exhaust manifold gas temperature falls below a predetermined level, the engine control system closes or partially closes the EGR control valve to stop EGR flow through the cooler and the EGR valve.

Abstract: This invention relates to a method for protecting an exhaust gas recirculation (EGR) valve from fouling due to hydrocarbon condensation at low EGR cooler outlet exhaust temperatures. In modern internal combustion engines exhaust gas recirculation (EGR) valves provide a means to recirculate exhaust gases into the intake air stream. The EGR valve regulates the flow of exhaust gas entering the stream. The EGR valve can experience fouling due to the condensation of hydrocarbons at low EGR cooler outlet exhaust temperatures. Typically, fouling occurs when the internal combustion engine is operating at relatively low temperatures, namely during low speed and/or low torque operations. The effects of fouling an EGR valve include higher emission levels, reduction in fuel economy, and rough idling.

Abstract: A motor vehicle has an engine compartment (123) and a compression ignition engine (100) disposed within engine compartment (123). Engine (100) has an air intake (110) through which combustion air enters the engine. A heater (120) heats combustion air passing through air intake (110). A sensor (116) indicates temperature in air intake (110). When temperature indicated by sensor (116) is greater than a reference temperature that demarcates a warm engine from a cold engine, a control (102) enables heater (120) to heat combustion air passing through air intake (110) upon engine starting and during a subsequent period of initial engine running whose duration is a function of temperature indicated by sensor (116) at engine starting.

Abstract: A motor vehicle (10) has wheels (22F, 22R) on which it travels, a powertrain (12) for delivering propulsion torque to at least some of the wheels to propel the vehicle, and a service brake system (24) having service brakes (28). When the service brakes are applied by a service brake actuator (26), braking torque is applied to at least some of the wheels. A first device (36) provides data representing a velocity that correlates with velocity of the vehicle, and a second device (38) associated with the actuator provides data that distinguishes between application and non-application of the service brakes by the actuator. A processor (34) monitors data from the first and second devices and processes the monitored data (FIG. 2) to provide a data output BPP_FLT when the first device has disclosed velocity change indicative of the service brakes having been applied without the second device having disclosed that the service brakes have been applied.

Abstract: A first fuel value (FL_Signal) indicative of the quantity of fuel presently in a fuel tank (34) and a second fuel value (FL_LOW_THLD) representing a quantity of fuel in the tank at which a maximum Injection Control Pressure (ICP) limit should be changed are processed by a processor (22). When the result of the processing discloses that the second fuel value is less than the first fuel value, the maximum ICP limit is reduced from a greater value (ICPC_NORMAL_LMX) to a lesser value (ICPC_FL_LMX).

Abstract: An engine processor (38) processes data for inferring temperature of exhaust gas at an exhaust manifold (18) of an internal combustion engine (10) whose exhaust system (16) contains an after-treatment device (26, 28) for treating exhaust gas and a sensor (30) for providing data for temperature of exhaust gas entering the after-treatment device. The processor processes data from the sensor and other data to infer temperature of exhaust gas at the exhaust manifold by executing an algorithm (FIGS. 3 and 4) that models temperature of exhaust gas at the exhaust manifold as a function of data from the sensor and the other data, including certain constants, certain geometry of the exhaust system, and certain variables related to operation of the engine.

Abstract: A first fuel value (FL_Signal) indicative of the quantity of fuel presently in a fuel tank (34) and a second fuel value (FL_LOW_THLD) representing a quantity of fuel in the tank at which a maximum Injection Control Pressure (ICP) limit should be changed are processed by a processor (22). When the result of the processing discloses that the second fuel value is less than the first fuel value, the maximum ICP limit is reduced from a greater value (ICPC_NORMAL_LMX) to a lesser value (ICPC_FL_LMX).

Abstract: A motor vehicle has an electric power supply that includes a battery bank (122), a compression ignition engine (100), different types of cold start aids (118, 120) that draw electric current from the power supply for aiding engine starting in cold ambient temperature, and a control (124) for monitoring voltage of the power supply while the cold start aids are drawing current from the battery bank and for interrupting the current to a lower priority one of the cold start aids, but not a higher priority one of the cold start aids, when monitored voltage falls below a threshold voltage.

Abstract: Torque being produced by a turbocharged internal combustion engine (12) during acceleration under load is calculated by processing (34) a value for actual boost MAP and a value MAP_NOMINAL selected from a map (32) that contains data values for boost that would prevail during steady state engine operation at a respective speed with the engine developing a respective torque. The selection is made using engine speed N and estimated torque TQI_SP that possesses some inaccuracy due to some disparity between the data value for actual boost and the data value selected from the map. The selection yields a boost disparity value that is used along with the estimated torque to select from a torque map (36) a value for calculated torque that provides a better correlation with actual torque than does the estimated torque during acceleration.