Patents by Inventor Rogelio Siles

Rogelio Siles has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • High affinity beta lactamase inhibitors
    Patent number: 9730913
    Abstract: Inhibitors of beta lactamases and their use in treating bacterial infections are disclosed.
    Type: Grant
    Filed: October 12, 2012
    Date of Patent: August 15, 2017
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Ernesto Freire, Rogelio Siles, Patrick C. Ross
  • Serine protease inhibitors
    Patent number: 9371307
    Abstract: Potent low molecular weight, highly selective, competitive non-peptidic serine protease inhibitors and their use in treating serine protease-associated diseases are disclosed.
    Type: Grant
    Filed: September 12, 2012
    Date of Patent: June 21, 2016
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Ernesto Freire, Patrick C. Ross, Rogelio Siles
  • SERINE PROTEASE INHIBITORS
    Publication number: 20150080451
    Abstract: Potent low molecular weight, highly selective, competitive non-peptidic serine protease inhibitors and their use in treating serine protease-associated diseases are disclosed.
    Type: Application
    Filed: September 12, 2012
    Publication date: March 19, 2015
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Ernesto Freire, Patrick C. Ross, Rogelio Siles
  • HIGH AFFINITY BETA LACTAMASE INHIBITORS
    Publication number: 20140256778
    Abstract: Inhibitors of beta lactamases and their use in treating bacterial infections are disclosed.
    Type: Application
    Filed: October 12, 2012
    Publication date: September 11, 2014
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Ernesto Freire, Rogelio Siles, Patrick C. Ross
  • Inhibitors of cysteine proteases and methods of use thereof
    Patent number: 8173696
    Abstract: The present invention relates to semicarbazone or thiosemicarbazone inhibitors of cysteine proteases and methods of using such compounds to prevent and treat protozoan infections such as trypanosomiasis, malaria and leishmaniasis. The compounds also find use in inhibiting cysteine proteases associated with carcinogenesis, including cathepsins B and L.
    Type: Grant
    Filed: June 13, 2008
    Date of Patent: May 8, 2012
    Assignee: Baylor University
    Inventors: Rogelio Siles, Ming Zhou, J. Freeland Ackley, Kevin G. Pinney, Shen-En Chen, Wara Milenka Arispe-Angulo, Mary Lynn Trawick
  • INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF
    Publication number: 20090076076
    Abstract: The present invention relates to semicarbazone or thiosemicarbazone inhibitors of cysteine proteases and methods of using such compounds to prevent and treat protozoan infections such as trypanosomiasis, malaria and leishmaniasis. The compounds also find use in inhibiting cysteine proteases associated with carcinogenesis, including cathepsins B and L.
    Type: Application
    Filed: June 13, 2008
    Publication date: March 19, 2009
    Applicant: Baylor University
    Inventors: Rogelio Siles, Ming Zhou, J. Freeland Ackley, Kevin G. Pinney, Shen-En Chen, Wara Milenka Arispe-Angulo, Mary Lynn Trawick